[1]王剑.乌灵胶囊对脑卒中后抑郁患者血清Hcy、神经细胞因子、 单胺类递质代谢和炎症反应的影响[J].陕西中医,2018,(10):1357-1359.
　Wang Jian..To investigate the depression after Wuling capsule on ischemic stroke patients serum Hcy，nerve cell factor，single amine neurotransmitter metabolism and the influence of the inflammatory response[J].,2018,(10):1357-1359.
点击复制

乌灵胶囊对脑卒中后抑郁患者血清Hcy、神经细胞因子、 单胺类递质代谢和炎症反应的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年10期
页码:
1357-1359
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
To investigate the depression after Wuling capsule on ischemic stroke patients serum Hcy，nerve cell factor，single amine neurotransmitter metabolism and the influence of the inflammatory response
文章编号:
DOI: 10.3969/j.issn.1000-7369.2018.10.012
作者:
王剑
河南省南阳市第一人民医院神经内科(南阳473000)
Author(s):
Wang Jian.
Department of Neurology， Nanyang First People’s Hospital of Henan Province (Nanyang 473000)
关键词:
中风后遗症抑郁/中西医结合疗法@乌灵胶囊
Keywords:
Key words Poststroke syndromeDepression/integrated Chinese traditional and western medicine therapy@Wuling capsule
分类号:
R255.2
文献标志码:
A
摘要:
摘要 目的 :探讨乌灵胶囊对缺血性脑卒中后抑郁(PSD)患者血清Hcy、神经细胞因子、单胺类递质代谢及炎症反应的影响。 方法: 选择PSD诊断标准的患者90例作为研究对象，随机分为观察组和对照组。对照组接受安慰剂治疗，观察组在此基础上给予乌灵胶囊。检测两组患者术前、术后4周血清Hcy、神经细胞因子(BDNF、 NGF)、单胺类递质代谢(5-HT、5-HIAA及NE)和炎症反应(IL-6 、IL-23、TNF-α)水平。结果:两组各检测指标治疗前均差异无统计学意义(P＞0.05)；治疗后，观察组的Hcy含量显著低于对照组(P＜0.05)；观察组的BDNF和NGF 水平显著高于对照组 (P＜0.05)；5-HIAA水平显著低于对照组(P＜0.05)；5-HT和NE水平显著高于对照组(P＜0.05)；IL-6 、IL-23和TNF-α水平显著低于对照组(P＜0.05)。结论:乌灵胶囊能够降低脑卒中后抑郁患者血清Hcy含量和神经细胞因子(BDNF、 NGF)含量，改善单胺类递质代谢(5-HT、5-HIAA及NE)和炎症反应(IL-6 、IL-23、TNF-α)，值得进一步研究。
Abstract:
Abstract Objective:To investigate the depression after Wuling capsule on ischemic stroke patients serum Hcy，nerve cell factor，single amine neurotransmitter metabolism and the influence of the inflammatory response.Methods：PSD criteria for the diagnosis of 90 cases of patients with as the research object，were randomly divided into observation group and control group.The control group received placebo treatment，observation group on the basis of Wuling capsule.Detection of two groups of patients with preoperative and postoperative serum Hcy 4 weeks，nerve cells factor (BDNF and NGF plays)，single amine neurotransmitter metabolism (5 - HT，5 HIAA and NE) and inflammation (IL - 6，IL - 23，TNF alpha) level.Results: before the treatment，each test indexes of two groups had no statistical difference (P＞0.05);After treatment，the observation group of Hcy levels decreased significantly (P＜0.05);Observation group of BDNF and NGF plays were significantly higher than that of control group (P＜0.05);5 - HIAA were significantly lower than control group (P＜0.05);5 - HT and NE were significantly higher than that of control group (P＜0.05);IL - 6，IL - 23 and TNF alpha were significantly lower than control group (P＜0.05).Conclusion：Wu ling capsule can reduce serum Hcy levels and depression after stroke patients nerve cells factor (BDNF and NGF plays) content，to improve the single amine neurotransmitter metabolism (5 - HT，5 HIAA and NE) and inflammation (IL - 6，IL - 23，TNF alpha)，deserves further research and extension.

参考文献/References:


[1] 四川省中医中药研究所. 四川中药志[M]. 成都：四川人民出版社，1960：1434.
[2]全国第四届脑血管病学术会议．各类脑血管疾病诊断要点[J]．中华神经科杂志，1996，12(6)：379.
[3]朱紫青，季建林．抑郁障碍诊疗关键[M]. 南京：江苏科学技术出版社，2003：21-27，51-74.
[4]国家中医药管理局．中医病症诊断疗效标准[M]．南京：南京大学出版社，1994：23.
[5]国家中医药管理局.中华人民共和国中医药行业标准一中医病证诊断疗致标准[M].南京：南京大学出版社，1994：20.
[6]陶源. 吗氯贝胺衍生物的合成及其抗抑郁活性[D].南华大学,2013.
[7]邓花,何艳华,成为荣,等. 奥氮平联合氟西汀治疗抑郁症的有效性和安全性研究[J]. 国际精神病学杂志,2015,42(2):18-20.
[8]赵峥,潘苗,张三强,等. 文拉法辛联合米氮平治疗难治性老年抑郁症的疗效及安全性[J]. 中国老年学 杂志,2013,33(10):2249-2251.
[9]欧秋明,邓思灵. 米氮平联合草酸艾司西酞普兰片治疗抑郁症的临床疗效及安全性评价[J]. 中国临床药理学杂志,2015,31(13):1252-1254.
[10]唐亚梅,周利君,刘勇,等. 抑郁症患者血清CRP、CER、Hcy和Anti-CCP抗体的浓度变化[J]. 实用预防医学,2012,19(9):1399-1401.

更新日期/Last Update: 2019-01-07