[1]王俊萍,陈文璐.参芪扶正注射液治疗慢性心衰疗效及对患者BNP、CRP、 MMP-9、TIMP-1水平的影响*[J].陕西中医,2018,(10):1366-1368.
　Wang Junping,Chen Wenlu..Effect of Shenqi Fuzheng injection on chronic heart failure and the levels of BNP，CRP，MMP-9 and TIMP-1[J].,2018,(10):1366-1368.
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参芪扶正注射液治疗慢性心衰疗效及对患者BNP、CRP、 MMP-9、TIMP-1水平的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年10期
页码:
1366-1368
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Effect of Shenqi Fuzheng injection on chronic heart failure and the levels of BNP，CRP，MMP-9 and TIMP-1
文章编号:
DOI: 10.3969/j.issn.1000-7369.2018.10.015
作者:
王俊萍1; 陈文璐2
1.陕西省友谊医院 （西安 710068）,2.西电集团医院（西安 710077）
Author(s):
Wang Junping; Chen Wenlu.
Shaanxi Friendship Hospital (Xi’an 710068)
关键词:
心力衰竭/中西医结合疗法参芪扶正注射液/治疗应用
Keywords:
Key words Heart failure /integrated Chinese traditional and western medicine therapyShenqi Fuzheng injection / therapeutic use
分类号:
R541.6
文献标志码:
A
摘要:
摘要 目的：探讨参芪扶正注射液治疗慢性心衰（CHF）的疗效及对BNP（B型利钠肽）、CRP（C反应蛋白）、MMP-9（基质金属蛋白酶9）、TIMP-1（金属蛋白酶组织抑制剂）水平的影响。方法：选取CHF患者120例均分为两组。对照组采用常规西医实施治疗，观察组在对照组基础上加用参芪扶正注射液进行治疗，治疗两周后对两组患者的治疗效果、BNP、CRP、MMP-9、TIMP-1水平进行观察研究。结果：对照组治疗有效率仅为88.33%，显著低于观察组（98.33%）（P＜0.05）；两组患者治疗前的BNP、CRP、MMP-9、TIMP1水平和中医症候积分比较，差异无统计学意义，但治疗后的BNP、CRP、MMP-9水平和中医症候积分均低于治疗前，TIMP-1水平高于治疗前，且观察组的各项指标水平均优于对照组（P＜0.05）；观察组不良反应的发生率为6.67%，低于对照组11.67%，两组比较差异无统计学意义（P＞0.05）。结论：参芪扶正注射液治疗慢性心衰效果显著，不良反应发生率低，推测其机制可能与低BNP、CRP、MMP-9水平和高TIMP-1水平有关。
Abstract:
Abstract Objective: To investigate the effect of Shenqi Fuzheng injection in the treatment of chronic heart failure (CHF) and BNP (B type natriuretic peptide CRP (C)，C-reactive protein (MMP-9)，matrix metalloproteinase 9 (TIMP-1)，tissue inhibitor of metalloproteinase) on the level. Methods: 120 patients with CHF who were divided into two groups. The control group using conventional western medicine treatment，the observation group on the basis of the control group was treated with Shenqi Fuzheng injection，was observed after 2 weeks of treatment in two groups of patients，BNP，CRP，MMP-9，TIMP-1. Results: the effective rate of the control group was only 88.33%，significantly lower than the observation group (98.33%) (P＜0.05); BNP，CRP，MMP-9，TIMP1 level and TCM syndrome score of the two groups of patients before treatment，the difference was not significant，but after treatment，BNP，CRP，MMP-9 level and TCM syndrome score were lower than before treatment，TIMP-1 was significantly higher than that before treatment，the levels of the indicators and the observation group were better than the control group (P＜0.05); the observation group the incidence rate of adverse reaction was 6.67%，11.67% lower than the control group，the difference between the two groups was not significant (P＞0.05). Conclusion: Shenq iFuzheng injection significantly in treatment of chronic heart failure effect，low incidence of adverse reactions，the mechanism might be related to low BNP，CRP，MMP-9 level and high level of TIMP-1.

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备注/Memo

备注/Memo:
*陕西省科技计划项目（2016K17-1-09-63）
更新日期/Last Update: 2019-01-07