[1]蔡亚宏,蔡文锋,熊丹△.小柴胡汤改善慢性肾小球肾炎患者炎症及减轻蛋白尿的作用研究*[J].陕西中医,2018,(10):1405-1407.
 Cai Yahong,Cai Wenfeng,Xiong Dan..Effect of Xiaochaihu decoction on inflammation and proteinuria in patients with chronic glomerulonephritis[J].,2018,(10):1405-1407.
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小柴胡汤改善慢性肾小球肾炎患者炎症及减轻蛋白尿的作用研究*

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年10期
页码:
1405-1407
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Effect of Xiaochaihu decoction on inflammation and proteinuria in patients with chronic glomerulonephritis
文章编号:
DOI: 10.3969/j.issn.1000-7369.2018.10.028
作者:
蔡亚宏1蔡文锋1熊丹2△
1.湖南中医药大学第一附属医院(长沙 410007),2.湖南省益阳市第一中医院泌尿外科(益阳 413000)
Author(s):
Cai YahongCai WenfengXiong Dan.
The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine( Changsha 410007)
关键词:
慢性肾小球肾炎/中西医结合疗法小柴胡汤肾功能
Keywords:
Key words Glomerulonephritis/integrated Chinese traditional and western medicineXiao Chai Hu TangRenal function
分类号:
R692.31
文献标志码:
A
摘要:
摘要 目的:研究小柴胡汤改善慢性肾小球肾炎患者炎症状态及减轻蛋白尿的作用。方法:将148例慢性肾小球肾炎随机分为对照组和治疗组,每组74例患者。对照组采用常规治疗,治疗组在对照组治疗基础上加服小柴胡汤,观察两组患者炎症及减轻蛋白尿的效果。结果:治疗组治疗总有效率为83.78%,明显高于对照组60.81%(P<0.05);治疗后两组患者24 h尿蛋白定量明显降低,与治疗前对比(P<0.05),且治疗组降低明显优于对照组(P<0.05);治疗后两组临床症状(头晕目眩、浮肿、恶心呕吐、食少纳呆)明显改善,与治疗前对比(P<0.05),治疗组改善明显优于对照组(P<0.05);治疗后两组患者炎症指标(IL-17、IFN-γ、IL-4)明显改善,与治疗前对比(P<0.05),治疗组改善明显优于对照组(P<0.05)。结论:小柴胡汤可改善慢性肾小球肾炎患者炎症状态,减轻蛋白尿,保护患者肾功能,改善患者预后。
Abstract:
Abstract Objective :To study the Xiaochaihu decoction improve inflammation in patients with chronic glomerulonephritis and reduce proteinuria. Methods: 148 cases of chronic glomerulonephritis patients were randomly divided into control group and treatment group,74 patients in each group.The control group received routine treatment,the treatment group based on the treatment in control group add services Xiaochaihu decoction,in two groups were observed and the effect of inflammation to reduce proteinuria. Results:The total efficiency of the treatment group was 83.78%,60.81% higher than the control group (P<0.05); the 2 groups after treatment 24h urinary protein decreased significantly,compared with before treatment (P<0.05),and the treatment group were significantly lower than those of control group (P<0.05); the 2 groups after treatment of clinical symptoms (swelling,dizzy,nausea and vomiting,anorexia) significantly improved,and than before treatment,and the treatment group improved significantly better than the control group (P<0.05); the 2 groups after treatment in patients with inflammatory index (IL-17,IFN-γ,IL-4) significantly improved,compared with before treatment (P<0.05),and the treatment group improved significantly better than the control group (P<0.05). Conclusion:Xiaochaihu decoction can improve the inflammation of patients with chronic glomerulonephritis,reduce proteinuria,protect the renal function of patients,and improve the prognosis of patients.

参考文献/References:


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备注/Memo

备注/Memo:
*湖南省中医药管理局科研项目(2209-38-70)
更新日期/Last Update: 2019-01-07