[1]洪丽萍,柳淑惠 △.复方肾衰汤联合羟苯磺酸钙治疗慢性肾脏病疗效及对患者症状评分的影响[J].陕西中医,2018,(10):1408-1410.
　Hong Liping,Liu Shuhui..Effect of compound Shenshuai decoction combined with calcium hydroxybenzenesulfonate on chronic kidney disease and its effect on patients’ symptom score[J].,2018,(10):1408-1410.
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复方肾衰汤联合羟苯磺酸钙治疗慢性肾脏病疗效及对患者症状评分的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年10期
页码:
1408-1410
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Effect of compound Shenshuai decoction combined with calcium hydroxybenzenesulfonate on chronic kidney disease and its effect on patients’ symptom score
文章编号:
DOI: 10.3969/j.issn.1000-7369.2018.10.029
作者:
洪丽萍1; 柳淑惠 2△
1.郑州颐和医院肾内科(郑州 450000)，2.西安大兴医院（西安710004）
Author(s):
Hong Liping; Liu Shuhui.
Department of Nephrology，Zhengzhou Yihe Hospital (Zhengzhou 450000)
关键词:
肾疾病/中西医结合疗法@羟苯磺酸钙@复方肾衰汤
Keywords:
Key words Kidney diseases/ integrated Chinese traditional and western medicine therapy @Calcium hydroxybenzenesulfonate@Compound Shenshuai decoction
分类号:
R692
文献标志码:
A
摘要:
摘要 目的：探讨羟苯磺酸钙联合复方肾衰汤治疗慢性肾脏病的疗效及对患者症状评分的影响。方法：选择慢性肾脏病患者126例，采用简单随机化方法分为对照组和观察组各63例。对照组采用羟苯磺酸钙治疗，观察组在此基础上采用复方肾衰汤治疗，两组均治疗1个月，评估治疗效果。记录并比较两组治疗前、后血肌酐（SCr）、血尿素氮（BUN）、血尿酸（UA）、24小时尿蛋白定量（24h-UP）及肌酐清除率（Ccr）等肾功能生化指标；记录并比较两组治疗后胃肠道不适、发热、皮疹、凝血异常等不良反应发生率；采用中医症候积分观察表评估临床症状改善情况，比较两组治疗前、后中医症状体征积分。结果：观察组和对照组治疗后SCr、BUN、UA和24h-UP水平均低于治疗前，Ccr高于治疗前（P＜0.05），其中观察组各项肾功能指标改善情况均优于对照组（P＜0.05）；观察组治疗后胃肠道不适、发热、皮疹、凝血异常等不良反应发生率与对照组比较差异无统计学意义（P＞0.05）；观察组与对照组治疗后中医症状体征积分均低于治疗前，其中观察组症状体征改善情况明显优于对照组（P＜0.05）。结论：羟苯磺酸钙联合复方肾衰汤治疗慢性肾脏病疗效理想，能改善临床症状，提高患者的肾功能水平，且不良反应较少，值得应用。
Abstract:
Abstract Objective: To investigate the effect of calcium dobesilate combined with compound Shenshuai decoction on chronic kidney disease and its effect on symptom scores. Methods: 126 patients with chronic kidney disease were selected and divided into control group （63 cases） and observation group （63 cases） by simple randomization method. The control group was treated with calcium dobesilate，and the observation group was treated with compound Shenshuai decoction on the basis of this. Both groups were treated for one month and the treatment effect was evaluated. To record and compare the renal function biochemical indexes such as serum creatinine （SCr），blood urea nitrogen （BUN），blood uric acid （UA），24-hour urine protein quantitation （24h-UP），and creatinine clearance （Ccr） before and after treatment in both groups. Records and compare the incidence of adverse reactions such as gastrointestinal discomfort，fever，rash，and coagulation abnormalities after treatment; used TCM symptoms integral observation table to evaluate the improvement of clinical symptoms，and compare a the scores of TCM symptoms and signs before and after treatment in both groups. Results: After treatment，the levels of SCr，BUN，UA and 24h-UP in the observation group and control group were lower than before treatment，and Ccr was higher than before treatment （P＜0.05）. The improvement of various renal function indexes in the observation group was superior to the control group. The incidence of gastrointestinal discomfort，fever，skin rash，abnormal coagulation and other adverse reactions after treatment in the observation group was not statistically different from that of the control group （P＞0.05）; the symptoms of TCM in the observation group and the control group after treatment. The scores of physical signs were all lower than those before treatment，and the improvement of symptoms and signs in the observation group was significantly better than that in the control group （P＜0.05）. Conclusion: Calcium dobesilate combined with compound shenshuai decoction is ideal for the treatment of chronic kidney disease. It can improve the clinical symptoms and improve the level of renal function in patients with fewer adverse reactions. It is worthy of popularization and application.

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更新日期/Last Update: 2019-01-07