[1]田新玮,刘丽丹,游碧荣,等.活血化瘀方联合来氟米特及甲氨蝶呤对类风湿关节炎患者凝血功能的影响[J].陕西中医,2018,(10):1435-1437.
　Tian Xinwei,Liu Lidan,You Birong,et al.Effect of Houxue Huayu decoction combined with leflunomide and methotrexate on coagulation function in patients with rheumatoid arthritis[J].,2018,(10):1435-1437.
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活血化瘀方联合来氟米特及甲氨蝶呤对类风湿关节炎患者凝血功能的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年10期
页码:
1435-1437
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Effect of Houxue Huayu decoction combined with leflunomide and methotrexate on coagulation function in patients with rheumatoid arthritis
文章编号:
DOI: 10.3969/j.issn.1000-7369.2018.10.038
作者:
田新玮1; 刘丽丹2; 游碧荣1; 陈昶3
1.新疆医科大学第五附属医院风湿免疫科（乌鲁木齐830011）， 2.新疆医科大学第六附属医院神经内科 （乌鲁木齐830000），3.山东滕州市中医医院肾病风湿科（滕州277599）
Author(s):
Tian Xinwei; Liu Lidan; You Birong; et al.
Department of Rheumatology and Immunology， The Fifth Affiliated Hospital of Xinjiang Medical University(Urumqi830011)
关键词:
关节炎; 类风湿/中西医结合疗法@活血化瘀方甲氨蝶呤
Keywords:
Key words Arthritis; rheumatoid/integrated Chinese traditional and western medicine therapy@Huoxue Huayu decoctionMethotrexate
分类号:
R593.22
文献标志码:
A
摘要:
摘要 目的：探讨活血化瘀方联合来氟米特和甲氨蝶呤常规西药方案治疗类风湿关节炎疗效及对患者凝血功能指标的影响。方法：选取类风湿关节炎患者89例为研究对象，随机分为治疗组与对照组，对照组患者给予常规西药治疗，治疗组患者给予活血化瘀方联合西药治疗，治疗结束后对两组疗效进行评价，并对比治疗前后症状积分、凝血功能、炎症因子等指标。结果：治疗组的临床总有效率更高（P＜0.05）；治疗后两组的症状积分、FIB、DD等指标均较其治疗前降低（P＜0.05），均低于对照组的同一指标（P＜0.05），对照组如上指标在治疗前后比较差异均不明显（P＞0.05）。结论：活血化瘀方联合西药治疗类风湿关节炎可有效降低患者FIB、DD指标的水平，改善患者的凝血功能。
Abstract:
Abstract Objective:To investigate the effect of Chinese medicinal formulae of Houxue Huayu decoction Stasis combined with leflunomide and methotrexate on coagulation function in patients with rheumatoid arthritis (RA). Methods: 89 cases of patients with rheumatoid arthritis were enrollmented as the research object，randomly divided into treatment group and control group，the control group were treated with conventional western medicine treatment，the treatment group were treated with Houxue Huayu decoction combined with western medicine treatment.Before and after treatment in the two groups，the efficacy and the changes of symptoms score，blood coagulation index，the level of inflammatory factors were evaluated and compared. Results:The total clinical effective rate was significantly higher in the treatment group than that of the control group (P＜0.05);After treatment in the treatment groups patients，the symptom score，FIB and DD were significantly lower than their treatment before (P＜0.05),the difference compared with the control group was significant(P＜0.05)，APTT，PT and blood coagulation in the control group patientshad no significant changes with their treatment before (P＞0.05).Conclusion: Activating Chinese medicinal formulae of blood circulation and dissipate blood stasis therapy combined with western medicine can effectively reduce the level of FIB and DD in patients with rheumatoid arthritis，and improve the blood coagulation function.

参考文献/References:


[1] 刘雪涛，李庆．类风湿性关节炎治疗药物进展[J].现代生物医学进展,2015，15(6):1171-1173,1014.
[2]Korotkova M,Jakobsson PJ.Persisting eicosanoid pathways in rheumatic diseases[J].Nat Rev Rheumatol,2014,10(4):229-241.
[3]Pincus T，Gibson KA，Castrejon I.Update on methotrexate as the anchor drug for rheumatoid arthritis[J]. Bulletin of the Hospital for Joint Diseases，2013，71(71Suppl 1):S9-19.
[4]Meissner B,Trivedi D,You M,et al.Switching of biologic disease modifying anti-rheumatic drugs in patients with rheumatoid arthritis in a real world settina[J].J Med Econ,2014,17(4):259-265.
[5]吕新亮，孙少敏，刘禹全,等. 甲氨蝶呤联合来氟米特治疗中医不同证型类风湿关节炎疗效比较研究[J]. 武警后勤学院学报：医学版，2014,11(3):190-193.
[6]中华人民共和国中医药行业标准. 风湿痹的诊断依据、证候分类、疗效评定——中华人民共和国中医药行业标准《中医内科病证诊断疗效标准》(ZY/T001.1-94)[J]. 辽宁中医药大学学报，2016，18(12):183.
[7]于笑霞,王晓磊,章鹏,等.通痹胶囊治疗寒湿痹阻型类风湿关节炎疗效观察[J].现代中西医结合杂志,2015,24(34):3797-3798.
[8]左瑞庭. 三因通痹汤治疗类风湿关节炎的疗效及对血清IL-1、TNF-α表达的影响[J]. 陕西中医，2017，38(8):51-52.
[9]武晔，王晓磊，姜淑华,等. 银苓消肿丸治疗湿热痹阻型类风湿关节炎临床疗效及安全性观察[J]. 陕西中医，2017，38(2):191-193.
[10]Nam JL,Ramiro S,Gauioux-viala C,et al.Efficacy of biological disease-modifying anti-rheumatic drugs:a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis[J].Ann Rheum Dis,2014,73(3):516-528.
[11]Ramiro S,Gaujoux-Viala C,Nam JL,et al.Safety of synthetic and biological DMARDS;a systematic literature review informing the 2013 update of EULAR recommendations for management of rheumatoid arthritis[J].Ann Rheum Dis,2014,73(3):529-535.
[12]Xie Y,Jiang ZH,Zhou H,et al.The pharmacokinetic study of sinomenine,paeoniflorin and paeonol in rats after oral administration of a herbal product Qingfu Guanjiesu Capsule by HPLC[J].Biomed Chromatogr,2014,28(9):1294-1302.
[13]李强,朱艳.正清风痛宁联合西药治疗类风湿性关节炎随机平行对照研究[J].实用中医内科杂志,2014,28(7):86-88.
[14]王健. 活跃性类风湿关节炎患者新蝶呤血浆浓度与疾病活动度相关性分析[J]. 陕西医学杂志，2016，45(8):1060-1061.
[15]曹向东,朱晓锋,马杰.舒筋固本方配合西药治疗寒湿痹阻型类风湿关节炎疗效观察[J].陕西中医,2014,35(12):1621-1623.

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更新日期/Last Update: 2019-01-07