[1]史碧霄,曹云,李烜△.胎盘多肽联合顺铂治疗胃癌腹腔积液疗效研究*[J].陕西中医,2018,(11):1504-1507.
　Shi Bixiao,Cao Yun,Li Xuan..The efficacy of placenta polypeptide combined with cisplatin on gastric peritoneal effusio[J].,2018,(11):1504-1507.
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胎盘多肽联合顺铂治疗胃癌腹腔积液疗效研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1504-1507
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
The efficacy of placenta polypeptide combined with cisplatin on gastric peritoneal effusio
文章编号:
10.3969/j.issn.1000-7369.2018.11.004
作者:
史碧霄; 曹云; 李烜△
南京中医药大学附属医院(南京 210029)
Author(s):
Shi Bixiao; Cao Yun; Li Xuan.
Affiliated Hospital of Nanjing University of Chinese Medicine(Nanjing 210029 )
关键词:
胃肿瘤/中西医结合疗法顺铂/治疗应用 胎盘提取物
Keywords:
Stomach neoplasms/integratedChinese traditional and western medicine therapyCisplatin/therapeutic usesPlacental extracts
分类号:
R735.2
文献标志码:
A
摘要:
目的: 研究胎盘多肽联合顺铂对胃癌腹腔积液的改善情况、免疫功能指标的变化、生存质量及不良反应的影响。方法:将40例胃癌腹腔积液患者随机分为治疗组与对照组，每组各20例。对照组给予腹腔灌注化疗方案：将0.9%氯化钠2000 ml和顺铂60 mg混合均匀后行腹腔灌注，灌注化疗每14 d行1次，共治疗4次；治疗组在对照组基础上加用胎盘多肽注射液8 ml加入 0.9%氯化钠注射液200 ml中，2次/d，每次化疗期间连续治疗10 d。两组均治疗4次后进行疗效〖JP2〗评价。结果 :治疗组和对照组患者腹腔积液的近期疗效无明显差别，差异无统计学意义(P>0.05)；治疗后,治疗组患者CD3+、CD4+及CD4+/CD8+高于对照组，CD8+下降明显，差异比较有统计学意义(P<0.05)；治疗后，治疗组患者KPS评分改善加稳定率比对照组高，不良反应发生率比对照组低，差异比较均有统计学意义(P<0.05)。结论:胎盘多肽联合顺铂对胃癌腹腔积液的改善无明显差别，但增强了患者的免疫功能，使患者生存质量得到提高，同时降低化疗产生的毒副反应，临床疗效较为理想。
Abstract:
Objective:To investigate the improvement of ascites in gastric cancer, changes in immune function, quality of life, and adverse reactions of placenta polypeptide combined with cisplatin. Methods:40 patients with gastric cancer with ascites were randomly divided into treatment group and control group, with 20 cases in each group. The control group was given intraperitoneal chemotherapy: 0.9% sodium chloride 2000ml and cisplatin 60mg were mixed and peritoneal perfusion was performed. Perfusion chemotherapy was performed once every 14 days for a total of 4 treatments. The placebo peptide was added to the control group on the basis of the control group. 8ml of injection was added into 200ml of 0.9% sodium chloride injection, ivgtt, bid, 10 days after each chemotherapy. Both groups were treated 4 times and evaluated for efficacy. Results:There was no significant difference in the short-term efficacy of intraperitoneal effusion between the treatment group and the control group (P>0.05). After treatment, the CD3+, CD4+ and CD4+/CD8+ in the treatment group were significantly higher than those in the control group. CD8+ decreased significantly, the difference was statistically significant (P<0.05); after treatment, the KPS score was significantly higher in the treatment group than in the control group (P<0.05); the incidence of adverse reactions in the treatment group was significantly lower than the control group,the difference was statistically significant (P<0.05).Conclusions:Placenta polypeptide combined with cisplatin has no significant difference in the improvement of abdominal cavity effusion in gastric cancer, but it can improve the immune function of patients, improve the quality of life of patients, reduce adverse reactions, it is worth further promotion and application of the clinical.

参考文献/References:

[1] 喻雯, 胡兴越, 倪建芳,等. 磁共振3D-TOF联合3D-FIESTA对原发性三叉神经痛病因的诊断价值[J]. 浙江医学, 2016, 38(18):1487-1490.
[2]郭玉涛, 屈建强. 微血管减压术治疗三叉神经痛的临床疗效分析[J]. 陕西医学杂志, 2016, 45(8):983-984.
[3] 冯霞.三叉神经痛病因及中西医结合治疗进展[J].中西医结合心血管病电子杂志,2017,5(31):25-26.
[4]王思博, 刘亢丁, 杨弋,等. 中国偏头痛患者右向左分流阳性率及分流类型—一项全国多中心研究[J]. 中国卒中杂志, 2018, 13(3):251-256.
[5]吴萍, 徐洋洋, 徐智强,等. 三叉神经痛的证治方药规律探析[J]. 中国中医急症, 2017, 26(2):201-203.
[6]胡兴祥, 徐维芳, 彭漪,等. 不同睡眠质量老年高血压病患者的晨峰血压达标率[J]. 中国心理卫生杂志, 2016, 30(7):492-495.
[7]朱洪宽, 张顺吉, 陈永伦. DSA引导射频热凝联合血府逐瘀方治疗原发性三叉神经痛疗效及对血浆β-内啡肽及P物质的影响[J]. 现代中西医结合杂志, 2017, 26(27):3020-3022.
[8]杨玲. 针灸、中药内服联用治疗三叉神经痛的疗效分析[J]. 中国实用医药, 2016, 11(5):169-170.
[9]李娜, 何亮亮, 王小平,等. 重复经颅磁刺激治疗原发性三叉神经痛的疗效及安全性分析[J]. 中国全科医学, 2016, 19(12):1387-1391.
[10]赵明, 刘铁镌, 栗雪梅. 针灸治疗气滞血瘀型三叉神经疼痛疗效观察[J]. 陕西中医, 2017, 38(5):665-667.
[11]王婧爱, 罗芳. 三叉神经痛发病的分子机制学研究进展[J]. 中国疼痛医学杂志, 2017, 23(1):55-58.
[12]石慧清, 于笑艳. 祛风通络汤加减方联合奥卡西平对早期三叉神经痛的疗效观察[J]. 陕西中医, 2016, 37(11):1466-1468.
[13]〖JP4〗赵少宁, 张占鹏, 王晓菊,等. 自拟熄风通络组方联合耳穴压籽治疗偏头痛疗效观察[J]. 中国处方药, 2016, 14(7):82-83.

备注/Memo

备注/Memo:
*江苏省中医消化病临床医学研究中心课题(BL2014100)
更新日期/Last Update: 2018-11-30