[1]魏海梁,李京涛△,闫曙光,等.八珍汤治疗恶性肿瘤化疗后白细胞减少症临床研究*[J].陕西中医,2018,(11):1508-1510.
　Wei Hailiang,Li Jingtao,Yan Shuguang,et al.Clinical safety and efficacy of Bazhen decoction on chemotherapy-induced myelosuppression and leucopenia for patients with malignant tumor[J].,2018,(11):1508-1510.
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八珍汤治疗恶性肿瘤化疗后白细胞减少症临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1508-1510
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Clinical safety and efficacy of Bazhen decoction on chemotherapy-induced myelosuppression and leucopenia for patients with malignant tumor
文章编号:
10.3969/j.issn.1000-7369.2018.11.005
作者:
魏海梁1; 李京涛1△; 闫曙光2; 肖刚1; 李婵3; 司明明1; 郭辉1
1.陕西中医药大学附属医院（咸阳712000），2.陕西中医药大学（咸阳712000），3.西安市第一医院（西安 710002）
Author(s):
Wei Hailiang; Li Jingtao; Yan Shuguang; et al.
The Affiliated Hospital of Shaanxi University of Chinese Medicine（Xianyang 712000）
关键词:
肿瘤/中西医结合疗法@白细胞减少症八珍汤/治疗应用
Keywords:
Neoplasms/integratedChinese traditional and western medicine therapy@LeukopeniaBa Zhen Tang /therapeutic uses
分类号:
R730.52
文献标志码:
A
摘要:
目的：评价八珍汤治疗恶性肿瘤化疗后白细胞减少症的临床疗效及安全性。方法:将60例恶性肿瘤放疗后继发性白细胞减少症、中医辨证为气血两虚的患者随机分为治疗组30例和对照组30例。对照组予以地榆升白片100 mg，3次/d；治疗组予以口服八珍汤汤剂400 ml，200 ml口服，2次/d。两组患者治疗两周为1个疗程，均服药3个疗程。比较两组治疗前后的白细胞数量、临床疗效以及不良反应发生率。结果:治疗后，两组患者白细胞数量较治疗前均明显上升(P＜0.05)，且治疗组白细胞数量明显高于对照组(P＜0.05)。治疗组总有效率为86.67%，明显高于对照组73.33%(P＜0.05)。两组患者均未见明显不良反应。结论:同地榆升白片相比，八珍汤用于治疗恶性肿瘤化疗后白细胞减少症的疗效更佳，且未见明显不良反应。
Abstract:
Objective:To evaluate clinical efficacy and safety of Bazhen decoction on chemotherapy-induced myelosuppression and leucopenia for patients with malignant tumor.Methods：Sixty cases with leukopenia after malignant tumor chemotherapy were randomly divided into treatment group and control group, 30 cases in each group.Patients in control group were treated with Diyu Shengbai tablets, 100 mg(po), 3 timesa day. Patients in treatment group were treated with Bazhen decoction,200ml once,twice daily. Two weeks for a course, and both groups were treated for 3 courses.The leukocyte count before and after treatmentand the clinical effect after treatment of two groups were compared, alsothe security was evaluated.Results：The total effective rate was 86.67% in treatment group, much higher than 73.33% in control group(P＜0.05).The leukocyte count apparently rised after treatment inboth groups (P＜0.05), while in treatment group, it rised to muchhigher than that in control group (P＜0.05). No obvious adverse reactions of the two groups occourred.Conclusion：Compared to Diyu Shengbai tablets, Bazhen decoction has better clinical efficacy on thetreatment of leukopenia after malignant tumor chemotherapy，simultaneously,there are no adverse reaction soccourred in both group.

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备注/Memo

备注/Memo:
*陕西省中医药管理局课题（JCMS042） 陕西省科技厅社会发展攻关项目（ 2017SF-338；2018SF-284） 咸阳市科学技术研究计划项目（ 2017k02-84）
更新日期/Last Update: 2018-11-30