[1]张森,何威华,华松,等.扶正消瘤汤对食管癌患者放疗前后临床症状、细胞免疫功能及外周血细胞凋亡的影响*[J].陕西中医,2018,(11):1511-1514.
　Zhang Sen,He Weihua,Hua Song,et al.The effects of Fuzheng Xiaoliu decoction on cellular immune function and peripheral blood cell apoptosis before and after radiotherapy of esophageal cancer patients[J].,2018,(11):1511-1514.
点击复制

扶正消瘤汤对食管癌患者放疗前后临床症状、细胞免疫功能及外周血细胞凋亡的影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1511-1514
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
The effects of Fuzheng Xiaoliu decoction on cellular immune function and peripheral blood cell apoptosis before and after radiotherapy of esophageal cancer patients
文章编号:
10.3969/j.issn.1000-7369.2018.11.006
作者:
张森1 ; 何威华2 ; 华松1 ; 王旸1 ; 余杰1; 刘杨3
1.郑州大学附属南阳医院（南阳市中心医院）放疗科 （南阳473009），2.武汉市中医医院肿瘤科（武汉 430014）， 3.郑州大学附属肿瘤医院放疗科 （郑州 450008）
Author(s):
Zhang Sen; He Weihua; Hua Song; et al.
Department of Radiotherapy,Nanyang Hospital Affiliated to Zhengzhou University(Nanyang City Central Hospital )(Nanyang 473009)
关键词:
食管肿瘤/中西医结合疗法免疫球蛋白A@〖WT5BZ〗扶正消瘤汤
Keywords:
Esophageal neoplasms/integrated Chinese traditional and western medicine therapyImmunoglobulin A@Fuzheng Xiaoliu decoction
分类号:
R735.1
文献标志码:
A
摘要:
目的：探讨扶正消瘤汤对食管癌患者放疗前后临床症状、细胞免疫功能及外周血细胞凋亡的影响。方法： 选取食管癌患者90例，随机分为治疗组和对照组各45例，对照组患者给予放疗治疗，治疗组患者使用扶正消瘤汤联合放疗治疗。观察两组患者吞咽困难缓解情况，比较两组患者治疗前后细胞免疫功能和血清免疫球蛋白水平，并对两组患者治疗前后中医证候积分和不良反应发生情况。结果：治疗组缓解率明显优于对照组，差异有统计学意义（P<0.05）；治疗前，两组患者免疫功能无明显差异（P>0.05），治疗后两组患者CD3+、CD4+、CD8+、CD4+/CD8+水平均有所改善，且治疗组水平明显优于对照组，差异有统计学意义（P<0.05）；治疗前，两组患者IgA、IgM、IgG无明显差异（P>0.05），治疗后两组患者血清免疫球蛋白水平均有所改善，且治疗组水平明显优于对照组，差异有统计学意义（P<0.05）；治疗前，两组患者吞咽困难、胸骨疼痛、呕吐黏液、食欲减退、神疲乏力等积分无明显差异（P>0.05）；治疗后，对照组胸骨疼痛、神疲乏力积分明显改善，治疗组各项积分明显优于对照组（P<0.05）；治疗组白细胞减少、血小板减少、骨髓抑制、便秘、恶心呕吐等不良反应发生率明显低于对照组，差异有统计学意义（P<0.05）。结论： 扶正消瘤汤可明显缓解食管癌患者放疗后吞咽困难情况，改善患者细胞免疫功能和血清免疫球蛋白水平，提高中医证候积分，且不良反应较少。
Abstract:
Objective :To investigate the effects of Fuzheng Xiaoliu decoction on cellular immunity and apoptosis of peripheral blood cells before and after radiotherapy of esophageal cancer patients.Methods: 90 cases of esophageal cancer patients in our hospital, were randomly divided into treatment group and control group, each 45 cases, the control group patients give radiation treatment, the treatment group patients using the centralizer tumor soup with radiation therapy. Observed two groups of patients with dysphagia ease the situation, compare two groups before and after treatment in patients with cellular immune function and serum immunoglobulin levels, and the two groups before and after treatment in patients with TCM syndrome integral and adverse reactions occur.Results: The remission rate of the treatment group (91.11%) was significantly better than the control group (73.33%) (P<0.05). before the treatment, two groups of immune function in patients with no significant difference (P>0.05), the two groups after treatment in patients with CD3+, CD4+, CD8+ and CD4+/ CD8+ level were improved, and the level of observation group was obviously better than the control group(P<0.05); before the treatment, two groups of patients with IgA, IgM and IgG no significant difference (P>0.05), serum immunoglobulin levels in both groups after treatment were improved, and the level of observation group was obviously better than the control group (P<0.05); before treatment, there was no significant difference between the two groups of patients with dysphagia, sternum pain, vomiting mucus, anorexia, and fatigue of god (P>0.05). After treatment, the score of the control group was significantly better than that of the control group before treatment, and the score of the observation group〖LM〗 was significantly better than that of the control group (P<0.05). The incidence of leukocyte reduction, thrombocytopenia, bone marrow transplantation, constipation, nausea and vomiting was significantly lower in the treatment group than in the control group(P<0.05).Conclusion: Fuzheng Xiaoliu decoction can obviously relieve dysphagia after radiotherapy in patients with esophageal cancer, improving cellular immune function in patients with and the level of serum immunoglobulin, improve the TCM syndrome integral, and less adverse reactions.

参考文献/References:

[1]陈婧,史涛.头孢米诺钠治疗医院获得性肺部感染临床研究[J].陕西医学杂志,2018,47(4):506-508.
[2]杨东星, 赵春香. 纤维支气管镜肺灌洗联合无创正压通气治疗重症肺部感染的临床效果及其对炎性因子的影响研究[J]. 实用心脑肺血管病杂志, 2016, 24(11):32-35.
[3]李飞飞, 张爱珍, 段鹏鹏. 加味六君子汤对慢性阻塞性肺疾病模型大鼠外周血肿瘤坏死因子-α白细胞介素-8含量及肺组织病理变化的影响[J]. 中国药物与临床, 2016, 16(4):492-494.
[4]中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版)[J]. 中华结核和呼吸杂志, 2013, 36(4):484-491.
[5]〖JP4〗奚肇庆, 郑玥. 中西医结合治疗重症肺炎痰热壅肺气阴两损证40例临床研究[J]. 江苏中医药, 2016, 48(3):29-31.
[6]郭亚萍. 降钙素原与临床肺部感染评分评估呼吸机相关性肺炎预后的研究[J]. 中国医药指南, 2016, 14(31):121-122.
[7]周茉, 陈建丽, 徐艳霞,等. PICU重症肺炎患儿机械通气后肺泡灌洗液NF-κB表达及炎性因子水平变化的研究[J]. 贵州医药, 2016, 40(8):807-809.
[8]邵弘毅. 自拟中药汤剂联合西药治疗急性心力衰竭疗效分析[J]. 中国中医药科技, 2016, 23(2):196-197.
[9]张军,冯卫星,刘燕妮.化痰祛瘀方联合咽三针治疗脑卒中吞咽障碍并发肺部感染疗效观察[J].陕西中医,2015,36(10):1314-1315.
[10]路光明. 白虎人参汤联合喜炎平注射液治疗重症肺部感染痰热腑实证临床研究[J]. 亚太传统医药, 2017, 13(20):154-155.
[11]孙建, 任柏沉, 杨帆,等. 纤维支气管镜吸痰联合常规抗感染治疗对重症肺部感染患者肺功能及炎症状态的影响[J]. 海南医学院学报, 2016, 22(13):1373-1376.
[12]张化芝,郭晓烨,李晓双,等.肺癌术后并发肺部感染的病原学分析及影响因素分析[J].中华医院感染学杂志,2018,28(1):77-80.
[13] 莫芳芳, 马师雷, 李鸿涛,等. 基于中医古籍研究的“肺与大肠相表里”理论源流及其内涵探讨[J]. 环球中医药, 2015, 8(2):165-168.
[14]罗胜, 梁结柱, 冼宙宁,等. 重症医学科多重耐药菌肺部感染的中医证候特征研究[J]. 湖南中医杂志, 2017, 33(9):1-5.

备注/Memo

备注/Memo:
*河南省科技厅重点科技攻关基金资助项目（142102310502）
更新日期/Last Update: 2018-11-30