[1]王琳.温肾方治疗自身免疫性甲状腺炎疗效及对患者血清细胞因子的影响*[J].陕西中医,2018,(11):1555-1558.
　Wang Lin..Effect of Wenshen decoction on autoimmune thyroiditis and its influence on serum cytokines[J].,2018,(11):1555-1558.
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温肾方治疗自身免疫性甲状腺炎疗效及对患者血清细胞因子的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1555-1558
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Effect of Wenshen decoction on autoimmune thyroiditis and its influence on serum cytokines
文章编号:
10.3969/j.issn.1000-7369.2018.11.019
作者:
王琳
河南省三门峡市中医院内分泌科 （三门峡 472000）
Author(s):
Wang Lin.
Department of Endocrinology, Sanmenxia Hospital of Traditional Chinese Medicine(Sanmenxia 472000)
关键词:
甲状腺炎;  自身免疫性/中西医结合疗法 甲状腺素/治疗应用@温肾方
Keywords:
Thyroiditis;  autoimmune/integrated Chinese traditional and western medicine therapyThyroxine/therapeutic uses@Wenshen decoction
分类号:
R581.4
文献标志码:
A
摘要:
目的：探讨温肾方对自身免疫性甲状腺炎的疗效及对相关血清细胞因子的影响。方法：选取自身免疫性甲状腺炎患者68例为研究对象。采用双盲法将其分为对照组和观察组，每组34例。对照组给予左旋甲状腺素钠片治疗，观察组在对照组基础上给予温肾方治疗。比较两组治疗前后甲状腺功能、细胞因子变化情况及临床疗效。结果：治疗后4、8、12周，两组患者中医症状积分均明显下降，且观察组比对照组下降更明显（P<0.05）。两组治疗前血清TSH、FT3、FT4、IL-4、IL-17、TGF-β及IFN-γ水平比较差异无统计学意义（P>0.05）；治疗后，两组血清TSH、IL-4、IL-17及IFN-γ水平均显著降低，FT3、FT4、TGF-β均显著升高（P<0.05）；观察组治疗后血清TSH、IL-4、IL-17及IFN-γ水平均低于对照组，FT3、FT4、TGF-β均高于对照组（P<0.05）。两组治疗后CD3+T水平均无明显变化（P>0.05），CD4+T及CD4+T/CD8+ T水平均显著升高（P<0.05），CD8+ T水平显著降低（P<0.05）；观察组治疗后CD4+T及CD4+T/CD8+ T水平明显高于对照组（P<0.05），CD8+ T水平明显低于对照组（P<0.05）。观察组总有效率为88.24%（30/34）明显高于对照组73.53%（25/34），（P<0.05）。观察组治疗后生活质量明显优于对照组（P＜0.05）。结论：温肾方可显著提高自身免疫性甲状腺炎患者甲状腺功能，维持机体免疫调节，降低炎症反应，临床疗效显著。
Abstract:
Objective： To investigate the effect of Wenshen decoction on autoimmune thyroiditis and its related serum cytokines. Methods :68 cases of autoimmune thyroiditis admitted were selected as the research subjects. They were divided into control group and observation group by double blind method, 34 cases in each group. The control group was treated with levothyroxine sodium tablets, and the observation group was given warm kidney prescription on the basis of the control group. The changes of thyroid function, cytokines and clinical efficacy were compared between the two groups before and after treatment.Result：After 4, 8, 12 weeks of treatment, the scores of TCM symptoms of the two groups were significantly decreased, and the observation group decreased more significantly than the control group (P< 0.05). There was no significant difference in serum TSH, FT3, FT4, IL-4, IL-17, TGF- beta and IFN- gamma in the two groups before treatment (P>0.05). After treatment, the average levels of serum TSH, IL-4, IL-17 and IFN- gamma in the two groups were significantly decreased. The average FT3, FT4 and TGF- beta levels were lower than those of the control group (P<0.05). There was no significant change in the level of CD3+T after treatment in the two groups (P>0.05), the average level of CD4+T and CD4+T/CD8+ T (P<0.05), CD8+ T level decreased significantly (P<0.05), and CD4+T and CD4+T/CD8+ T levels in the observation group were significantly higher than those of the control group. The total effective rate of the observation group was 88.24% (30/34), which was significantly higher than that of the control group (73.53%，P<0.05). The quality of life of the observation group after treatment was significantly better than that of the control group (P< 0.05).Conclusion：Wenshen decoction can significantly improve the thyroid function of the patients with autoimmune thyroiditis, maintain the immune regulation of the body and reduce the inflammatory reaction. The clinical effect is 〖LM〗remarkable. It is worth popularizing.

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备注/Memo

备注/Memo:
*河南省科技计划项目（20140HN253）
更新日期/Last Update: 2018-11-30