[1]梅江涛,戴先文,尚辉辉,等.腰痛宁胶囊联合归元筋骨宁湿敷剂治疗腰椎间盘突出症临床研究*[J].陕西中医,2018,(11):1569-1572.
　Mei Jiangtao,Dai Xianwen,Shang Huihui,et al.Analysis of therapeutic effect of Yaotongning capsule combined Guiyuan Jinguning moisturizer on lumbar intervertebral disc protrusion[J].,2018,(11):1569-1572.
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腰痛宁胶囊联合归元筋骨宁湿敷剂治疗腰椎间盘突出症临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1569-1572
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Analysis of therapeutic effect of Yaotongning capsule combined Guiyuan Jinguning moisturizer on lumbar intervertebral disc protrusion
文章编号:
10.3969/j.issn.1000-7369.2018.11.023
作者:
梅江涛1; 戴先文1; 尚辉辉1; 冯凯隆1; 任加森2△
1.长安医院骨科 (西安710016)，2.陕西省富平县八里店骨伤医院（富平711799）
Author(s):
Mei Jiangtao;  Dai Xianwen;  Shang Huihui; et al.
The Orthopaedic of Chang’an Hospital (Xi’an 710016)
关键词:
椎间盘移位/中医药疗法腰椎@腰痛宁胶囊
Keywords:
Intervertebral disc displacement/traditionalChinese medicine therapyLumbar vertebrae@Yaotongning capsule
分类号:
R683.2
文献标志码:
A
摘要:
目的：探讨腰痛宁胶囊联合归元筋骨宁湿敷剂治疗腰椎间盘突出症（LDH）的疗效。方法：将符合纳入标准的90例LDH患者均分为两组，对照组单独使用腰痛宁胶囊治疗；观察组采用腰痛宁胶囊与归元筋骨宁湿敷剂联合方式进行治疗。治疗后对比两组静息和活动状态下止痛起效时间及临床有效率；比较两组治疗前及治疗2周、4周时疼痛VAS评分、JOA及ODI评分变化情况；测定两组血清学指标。结果：治疗后，观察组临床总有效率为95.56%，明显高于对照组（80.00%，P＜0.05）。对照组、观察组者静息及活动状态下止痛起效时间均明显缩短（P＜0.05）。随着用药时间延长，两组静息及活动状态下疼痛VAS评分及ODI评分均明显下降，JOA评分均明显提高（P＜0.05），血清指标MCP-1、PGE-2、IL-1及IL-6水平均明显下降（P＜0.05）；但观察组疼痛VAS评分及ODI功能评分及4项血清学指标下降更明显，JOA评分升高更明显（P＜0.05）。结论：腰痛宁胶囊与归元筋骨宁湿敷剂联合治疗LDH收益甚好，可更好的改善患者临床症状，快速缓解疼痛，改善患者腰椎功能，提高患者生活质量。
Abstract:
Objective:To investigate the curative effect of Yaotongning capsule combined with Guiyuan Jinguning moisturizer on the treatment of lumbar disc herniation (LDH).Methods:The 90 LDH patients meeting the inclusion criteria were divided into two groups. The control group was treated with Yaotongning capsule alone. The experimental group was treated with Yaotongning capsule and Guiyuan Jinguning moisturizer. After treatment, the onset time at resting and active state was compared between the two groups,and the clinical efficacy of analgesia was compared between two groups.The scores of VAS,JOA and ODI were compared before and after treatment for 2 weeks and 4 weeks in two groups.The serological indicators were determined in two groups. Results:After treatment, the total effective rate in the experimental group was 95.56%, which was significantly higher than that in the control group (80.00%,P<0.05).Compared with the control group, the onset time of analgesia under resting and active state was significantly shortened in the experimental group (P<0.05).With the prolonged treatment time, the scores of VAS and ODI scores in both groups were significantly decreased, and JOA scores were significantly increased(P<0.05).The serum levels of MCP-1, PGE-2, IL-1 and IL-6 were significantly decreased (P<0.05).However, compared with the control group, the scores of VAS, ODI and four serological indicators in the experimental group decreased more significantly,and the scores of JOA increased more significantly(P<0.05).Conclusion:The combination of Yaotongning capsule and Guiyuan Jinguning moisturizer is very good for the treatment of LDH, which can better improve the clinical symptoms of patients, relieve pain quickly, improve lumbar function and the quality of life of patients.

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备注/Memo

备注/Memo:
*陕西中医药大学科研创新基金资助项目(14XJRW-06)
更新日期/Last Update: 2018-11-30