[1]赵静瑜,吴际,王乃平,等.雷公藤多苷联合免疫抑制剂治疗肾病综合征临床研究*[J].陕西中医,2018,(11):1592-1595.
　Zhao Jingyu,Wu Ji,Wang Naiping,et al.Clinical efficacy of tripterygium glycosides combined with immunosuppressive agents in the treatment of nephrotic syndrome[J].,2018,(11):1592-1595.
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雷公藤多苷联合免疫抑制剂治疗肾病综合征临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1592-1595
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Clinical efficacy of tripterygium glycosides combined with immunosuppressive agents in the treatment of nephrotic syndrome
文章编号:
10.3969/j.issn.1000-7369.2018.11.030
作者:
赵静瑜; 吴际; 王乃平; 赵盼
河南省开封市中心医院（开封 475000）
Author(s):
Zhao Jingyu;  Wu Ji;  Wang Naiping; et al.
Kaifeng City Center Hospital(Kaifeng 475000)
关键词:
肾病综合征/中西医结合疗法免疫抑制药/治疗应用雷公藤/治疗应用
Keywords:
Nephrotic syndrome/integratedChinese traditional and western medicine therapyImmunosuppressive agents/therapeutic uses Tripterygium wilfordii/therapeutic uses
分类号:
R692.9
文献标志码:
A
摘要:
目的：探讨雷公藤多苷联合免疫抑制剂治疗肾病综合征的临床疗效及安全性。方法：选取肾病综合征患者72例为研究对象。采用随机数字表分组法将其分为对照组和观察组，每组36例。所有患者均开展保肾、降压、利尿、抗凝、抗感染、低盐低蛋白饮食等基础性治疗。对照组患者给予醋酸泼尼松片治疗，观察组在对照组基础上给予雷公藤多苷片治疗。比较两组治疗前后血清BUN、Scr、ALB、24 h尿蛋白定量、临床疗效及不良反应情况。结果：治疗前两组患者中医证候积分无明显差异（P＞0.05），治疗2、4、6个月后，两组患者的中医证候积分均明显下降，且观察组比对照组下降更明显，差异具有统计学意义（P＜0.05）。两组治疗前TC及TG水平比较差异无统计学意义（P>0.05）；治疗后两组TC及TG水平均显著降低，差异具有统计学意义（P<0.05）；观察组治疗后TC及TG水平显著低于对照组，差异具有统计学意义（P<0.05）。两组治疗前血清BUN 、Scr、ALB及24　h尿蛋白定量比较差异无统计学意义（P>0.05）；治疗后，两组血清ALB升高，BUN 、Scr及24 h尿蛋白定量均降低（P<0.05）；观察组治疗后血清ALB明显高于对照组，BUN 、Scr及24 h尿蛋白定量明显低于对照组（P<0.05）。观察组总有效率为86.11%（31/36）；明显高于对照组63.89%（23/36），差异具有统计学意义（P<0.05）。两组临床不良反应情况比较无统计学意义（P>0.05）。两组治疗前生活质量评分比较差异无统计学意义（P>0.05）；两组治疗后生活质量评分显著升高，与治疗前比较差异有统计学意义（P<0.05）。结论：雷公藤多苷联合免疫抑制剂可显著提高肾病综合征患者血清ALB水平，降低TC、TG、BUN 、Scr及24 h尿蛋白定量，并可提高患者生活质量，临床疗效显著，且用药安全。
Abstract:
Objective: To investigate the clinical efficacy and safety of tripterygium glycosides combined with immunosuppressive agents in the treatment of nephrotic syndrome. Methods :72 patients with nephrotic syndrome admitted were selected as the research subjects. They were divided into control group and observation group by random number table grouping method, 36 cases in each group. All patients underwent basic treatment such as kidney protection, hypotension, diuresis, anticoagulation, anti infection, low salt and low protein diet. The patients in the control group were treated with prednisone acetate tablets, and the observation group was given tripterygium glycosides tablets on the basis of the control group. The serum BUN, Scr, ALB and 24 h urinary protein quantitation, clinical efficacy and adverse reactions were compared between the two groups before and after treatment. Results: There was no significant difference in TCM syndrome scores between the two groups before treatment (P> 0.05). After 2, 4, 6 months, the TCM syndrome scores of the two groups were significantly decreased, and the observation group was more obvious than the control group, the difference was statistically significant (P< 0.05). There was no significant difference in the level of TC and TG before treatment in the two groups (P>0.05), and the levels of TC and TG decreased significantly in the two groups after treatment, and the difference was statistically significant (P<0.05). The level of TC and TG in the observation group was significantly lower than that of the control group (P<0.05). There was no significant difference in the quantitative comparison of serum BUN, Scr, ALB and 24 h urine protein before treatment (P>0.05). After treatment, the serum ALB increased in the two groups, BUN, Scr and 24 h urine protein decreased (P<0.05), and the serum ALB was significantly higher than that of the control group after treatment. (P<0.05). The total effective rate of the observation group was 86.11% (31/36), 〖LM〗which was significantly higher than that of the control group (63.89% (23/36), and the difference was statistically significant (P< 0.05). There was no significant difference in clinical adverse reactions between the two groups (P>0.05). There was no significant difference in the quality of life scores between the two groups (P>0.05), and the scores of the quality of life in the two groups after treatment in the two groups were significantly increased, and there was a significant difference between the two groups after treatment (P<0.05). Conclusion :The combination of Tripterygium wilfordii combined with immunosuppressant can significantly increase the level of serum ALB in patients with nephrotic syndrome, reduce the quantity of TC, TG, BUN, Scr and 24 h urine protein, and improve the quality of life of the patients, and the clinical efficacy is significant, and safety.

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备注/Memo

备注/Memo:
*河南省医学科技攻关计划项目（201404038）
更新日期/Last Update: 2018-11-30