[1]樊英,康淑红△.抗喘利肺汤联合西药治疗小儿哮喘临床研究*[J].陕西中医,2018,(11):1602-1605.
　Fan Ying,Kang Shuhong..Clinical effect of Kangchuan Lifei decoction with western medicine in Children bronchial asthma with positive allergens action[J].,2018,(11):1602-1605.
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抗喘利肺汤联合西药治疗小儿哮喘临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1602-1605
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Clinical effect of Kangchuan Lifei decoction with western medicine in Children bronchial asthma with positive allergens action
文章编号:
10.3969/j.issn.1000-7369.2018.11.033
作者:
樊英; 康淑红△
陕西省宝鸡市妇幼保健院儿科 （宝鸡 721000）
Author(s):
Fan Ying; Kang Shuhong.
Department of Paediatrics,Maternal and Child Health Hospital in Baoji( Baoji 721000)
关键词:
哮喘/中西医结合疗法儿童@抗喘利肺汤
Keywords:
Asthma/integratedChinese traditional and western medicine therapy Child@ Kangchuan Lifei decoction
分类号:
R725.6
文献标志码:
A
摘要:
目的：探讨抗喘利肺汤联合西药对伴变应原检测阳性的小儿哮喘临床疗效的影响。方法：利用随机数字表法将278例伴变应原检测阳性的小儿哮喘患儿分为观察组和对照组，每组139例。对照组患儿均给予西药常规治疗，观察组则在对照组的基础上另给予自拟抗喘利肺汤。治疗后，评价两组患儿的临床疗效。治疗前后，检测两组平均呼气流量峰值（PEF）、肺活量（FVC）、1s用力呼气量占肺活量的百分比（FEV1/FVC%）及一秒用力呼气容积（FEV1）\]；观察两组胸闷、咳嗽、咳痰、短气喘促及吸气不利等中医证候评分；检测Toll样受体2（TLR2）、嗜酸性粒细胞趋化因子（Eotaxin）、嗜酸性阳离子蛋白（ECP）、巨噬细胞炎性蛋白-1α（MIP-1α）及淀粉样蛋白A（SAA）量。结果：治疗后，观察组总有效率显著高于对照组（P<0.05）。〖JP3〗治疗后，观察组PEF、FVC、FEV1/FVC%及FEV1均明显高于对照组（P<0.05），而胸闷、咳嗽、咳痰、短气喘促及吸气不利评分则明显低于对照组（P<0.05）。治疗后，观察组TLR2、Eotaxin、ECP、MIP-1α及SAA改善程度均明显优于对照组（P<0.05）。结论：抗喘利肺汤联合西药对伴变应原检测阳性的小儿哮喘疗效较好。
Abstract:
Objective: To explore the clinical effect of Kangchuan Lifei decoction with western medicine in bronchial asthma children with positive allergens action. Methods: 278 bronchial asthma children with positive allergens action in our hospital were divided control group and observe group by a random way, 139 cases in each group. The control group was treated by routine western medical treatment, while Kangchuan Lifei decoction was treated in observe group on the base of control group. After the treatment, the effects in the 2 groups were compared. Before and after the treatment, the levels of lung function \[average expiratory flow peak (PEF), lung capacity (FVC), 1s force expiratory volume (FEV1/FVC%) and one second forced expiratory volume (FEV1)\] were detected, while traditional Chinese medicine syndrome scores (chest tightness, cough, expectoration, shortness breath and inhalation) were observed in the two groups. Before and after the treatment, the levels of asthma markers \[toll-like receptor 2 (TLR2), eosinophil chemotactic factor (Eotaxin), eosinophilic cationic protein (ECP), macrophage inflammatory protein - 1 alpha (MIP-1α) and serum amyloid A (SAA)\] were detected in the 2 groups. Results: After the treatment, the effect rate in the observe group was significantly higher than control group (P<0.05). After the treatment, the levels of PEF, FVC, FEV1/FVC% and FEV1 were significantly higher in the observe group, while the levels of TLR2, Eotaxin, ECP, MIP-1α and SAA were significantly promoted than the control group (P<0.05). After the treatment, the scores of chest tightness, cough, expectoration, shortness breath and inhalation in the observe group were significantly lower than the observe group (P<0.05). Conclusions: Kangchuan Lifei decoction with western medicine in bronchial asthma children with positive allergens action has a good effect.

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备注/Memo

备注/Memo:
*陕西省教育厅自然科学研究项目（2013JK0773）
更新日期/Last Update: 2018-11-30