[1]郭改玲,王玉霞.葛根固敛汤联合蒙脱石散治疗小儿腹泻疗效及对患儿血清炎性因子的影响*[J].陕西中医,2018,(11):1613-1616.
　Guo Gailing,Wang Yuxia..Gegen Gulian decoction and montmorillonite powder in the treatment of infantile diarrhea and its effect on serum inflammatory factors[J].,2018,(11):1613-1616.
点击复制

葛根固敛汤联合蒙脱石散治疗小儿腹泻疗效及对患儿血清炎性因子的影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1613-1616
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Gegen Gulian decoction and montmorillonite powder in the treatment of infantile diarrhea and its effect on serum inflammatory factors
文章编号:
10.3969/j.issn.1000-7369.2018.11.036
作者:
郭改玲1; 王玉霞2
1.鹤壁煤业（集团）有限责任公司总医院儿科（鹤壁458030）， 2.河南中医学院第三附属医院中医内科（郑州 450004）
Author(s):
Guo Gailing; Wang Yuxia.
Department of Paediatrics,General Hospital of Hebi Coal (Group) Co., Ltd.（Hebi 458030）
关键词:
腹泻/中西医结合疗法儿童@蒙脱石散@葛根固敛汤
Keywords:
Diarrhea/integrated Chinese traditional and western medicine therapyChild@Montmorillonite powder@Gegen Gulian decoction and montmorillonite powder
分类号:
R725.7
文献标志码:
A
摘要:
目的：观察葛根固敛汤联合蒙脱石散治疗小儿腹泻的临床疗效及对患儿血清炎性因子的影响。方法：选取118例腹泻患儿作为观察资料，将入选患儿随机均分为两组，其中对照组采取蒙脱石散治疗，研究组在对照组治疗的基础上联合应用本院自拟葛根固敛汤治疗；治疗1疗程后，评估两组临床疗效，观察两组患儿主要临床症状康复时间，观察两组患儿治疗前后血清炎性因子的变化情况，统计治疗过程中不良反应发生情况，随访3个月对比两组患儿的复发情况。结果：治疗1疗程后，研究组总有效率为96.61%，对照组总有效率为86.44%；研究组总有效率与整体疗效水平均优于对照组（P<0.05）；研究组患儿发热、排便次数、大便性状、常规便检恢复至正常水平的时间均短于对照组患儿（P<0.05）。治疗后两组患儿血清hs-CRP、TNF-α、IL-6、IL-8、IL-10表达水平均较前改善，组内对比差异具有统计学意义；治疗后研究组各项血清炎性因子表达水平均优于对照组，组间对比差异具有统计学意义。研究组患儿便秘、大便干结发生率与随访中复发率均低于对照组，差异具有统计学意义。结论：葛根固敛汤联合蒙脱石散治疗小儿腹泻疗效理想，可促进患儿尽早康复，降低患儿血清炎性因子水平，减轻不良反应并预防复发。
Abstract:
Objective: Observe the clinical effect of the treatment of infantile diarrhea and its effect on serum inflammatory factors. Methods: Selected 118 cases of diarrhea as the observation data, randomly divided into two groups, the control group treated with montmorillonite powder, based on the treatment of the control group, the study group was applied to the treatment of Gegen Gulian decoction. After a period of treatment, evaluated two groups of clinical curative effect, observe two groups of children with main clinical symptoms of recovery time, observe the two groups before and after treatment in children with the change of serum inflammatory factors, adverse reactions occurred in the process of statistical treatment, follow-up three months compared to two groups of children with relapse. Results: After treatment, the total effective rate of the two group was 96.61% and 86.44%. The total efficiency and overall efficacy of the study group were superior to the control group（P<0.05）. In the study group, the time of fever, defecation, defecation and routine examination and recovery to normal levels were shorter than those in the control group（P<0.05）. Serum hs-crp, TNF-α, IL-6, IL-8, and IL-10 expression levels were all improved in the two groups after treatment(P<0.05). After treatment, the expression levels of serum inflammatory factors were better than the control group(P<0.05). The incidence and recurrence rate of constipation and stools in the study group were lower than the control group(P<0.05). Conclusion: The curative effect of Gegen Gulian decoction combined with montmorillonite powder in the treatment of infantile diarrhea is ideal, which can promote early recovery of children, reduce serum inflammatory cytokines level, reduce adverse reactions and prevent recurrence.

参考文献/References:

[1] 张向红,程黎晖.大黄的药理作用及临床应用研究进展[J].中国药业,2009,18(21):76-78.
[2] 王阳,林鹏程,明升平,等.四种大黄属高山药用植物蒽醌类成分含量的测定[J].湖北农业科学,2017,56(10):1945-1946,1952.
[3]巩丹丹,董嘉俊,孙国祥,等.用高效液相色谱组方指纹图谱智能预测中药质量的新模式[J].色谱,2017,35(6):643-649.
[4]杨方良,张晶,孙国祥,等.中药组方指纹图谱研究方法和思路[J].色谱,2016,34(7):715-725.
[5]杨艳.反相高效液相法测定复方胆通胶囊中大黄酚及大黄素含量[J].实用药物与临床,2013,16(1):45-47.
[6]李会芳,王伽伯,金城,等.基于UPLC指纹图谱的市售大黄不同饮片品质研究[J].时珍国医国药,2012,23(9):2314-2316.
[7]王宁芳.青海不同产区大黄的HPLC指纹图谱的对比研究[J].安徽农业科学,2014,42(12):3477-3478,3482.
[8]蔡惠芬,罗鹏,王珂,等.大黄注射液对犬血管搭桥术后纤溶系统的影响[J].畜牧兽医学报,2010,41(7):897-901.
[9]宋雨泽,曾滨阳,任历，等.生物效价法测定大黄炮制品活血化瘀功效[J].中成药,2014,36(9):1921-1924.
[10] 宋景春,林青伟,曾庆波，等.大黄素对脓毒症后期小鼠血小板功能的调节作用[J].医学研究生学报,2017,30(7):709-714.
[11]关洪月,李林,刘晓,等.中药指纹图谱相似度计算方法探析[J].中国实验方剂学杂志,2011,17(18):292-297.
[12] 聂磊,曹进,罗国安,等.中药指纹图谱相似度评价方法的比较[J].中成药,2005,27(3):249-252.
[13] 窦志华,乔进,卞理,等.指纹图谱与一测多评法相结合的大黄质量控制方法[J].中国药学杂志, 2015, 50(5):442-448.
[14]杜清涛,温金莲,严优芍,等.不同品种不同产地大黄UPLC指纹图谱研究[J].中药材,2013,36(5):725-731.
[15] 郭东艳,柳小莉,唐志书,等.大黄不同炮制品化学成分转移规律研究[J].现代中西医结合杂志,2014,23(18):2016-2017.

备注/Memo

备注/Memo:
*河南省科技攻关重点项目(092102310297)
更新日期/Last Update: 2018-11-30