[1]秦晓娟,祁海燕△.针刺联合沙美特罗替卡松对支气管哮喘患者肺功能、血清炎症反应及T淋巴细胞亚群的影响[J].陕西中医,2018,(11):1630-1633.
　Qin Xiaojuan..Effect of acupuncture combined with salmeterol on pulmonary function, serum inflammatory response and T lymphocyte subsets in patients with bronchial asthma[J].,2018,(11):1630-1633.
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针刺联合沙美特罗替卡松对支气管哮喘患者肺功能、血清炎症反应及T淋巴细胞亚群的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1630-1633
栏目:
针灸经络
出版日期:
2018-12-31

文章信息/Info

Title:
Effect of acupuncture combined with salmeterol on pulmonary function, serum inflammatory response and T lymphocyte subsets in patients with bronchial asthma
文章编号:
10.3969/j.issn.1000-7369.2018.11.041
作者:
秦晓娟1; 祁海燕2△
1.陕西省汉中市人民医院呼吸内科 (汉中 723000），2.陕西省中医医院（西安710003）
Author(s):
Qin Xiaojuan.
Respiratory Medicine，Hanzhong People's Hospital （Hanzhong 723000）
关键词:
哮喘/针灸疗法支气管穴; 大椎穴; 膻中
Keywords:
Asthma/acupuncture-moxibustionBronchiPoint GV14(Dazhui) Point CV17(Tanzhong)
分类号:
R562.25
文献标志码:
A
摘要:
目的： 探讨针刺联合沙美特罗替卡松治疗支气管哮喘（BA）急性发作期的临床效果及其对患者肺功能、血清炎症反应及T淋巴细胞亚群的影响。方法： 将入选的128例BA急性发作期患者均分为两组，对照组采用沙美特罗替卡松粉吸入剂进行治理；观察组使用针刺联合沙美特罗替卡松粉吸入剂进行治疗。对比两组治疗前后肺功能指标（FEV1、FVC、PEF）、血清炎症因子（IFN- 䥺SymbolgA@ 、IL-8、IL-4）、T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+）值变化情况；统计两组临床显控率及总有效率。结果：治疗后，两组肺功能指标FEV1、FVC、PEF值、血清炎症因子IFN-水平及T淋巴细胞亚群CD3+、CD4+、CD4+/CD8+值均明显升高（P＜0.05）；血清炎症因子IL-8、IL-4水平及T淋巴细胞亚群CD8+含量均明显降低（P＜0.05）。且与对照组比，观察组肺功能指标、血清炎症因子及T淋巴细胞亚群指标含量变化更明显（P＜0.05）。观察组临床显控率71.88%，总有效率为96.88%，对照组则分别为46.88%，82.81%，两组临床显控率及总有效率间差异有统计学意义（P＜0.05）。结论： 针刺联合沙美特罗替卡松治疗急性发作期BA可有效控制患者临床症状，改善患者肺功能，抑制机体炎症反应，提高机体免疫力，疗效明显优于单纯沙美特罗替卡松。
Abstract:
Objective： To investigate the clinical effect of acupuncture combined with salmeterol triamcinolone in the treatment of acute exacerbation of bronchial asthma (BA) and its effect on lung function, serum inflammatory response, and T lymphocyte subsets. Methods ：The 128 acute exacerbation patients who were enrolled in the study were divided into two groups.The control group was treated with salmeterol monohydrate inhaler, the observation group was treated with acupuncture combined with salmeterol monohydrate inhaler.The changes in lung function parameters (FEV1, FVC, PEF), serum inflammatory factors (IFN-, IL-8, IL-4), and T lymphocyte subsets (CD3+, CD4+, CD8+, and CD4+/CD8+) before and after treatment were compared in the two groups;the clinical manifestation rate and total effective rate in two groups was counted. Results ：After treatment, the FEV1, FVC, PEF values, serum inflammatory cytokines, and T lymphocyte subsets CD3+, CD4+, and CD4+/CD8+ values were significantly increased in both groups (P<0.05),the levels of serum inflammatory cytokines IL-8, IL-4 and CD8+ in T lymphocyte subsets were significantly lower (P<0.05).Compared with the control group, the changes of lung function, serum inflammatory factors and T lymphocyte subsets were more obvious in the observation group (P<0.05).The clinical display control rate of the observed group was 71.88%, the total effective rate was 96.88%,and the control group was 46.88% and 82.81% ,respectively.There was a significant difference of the clinical manifestation rate and total effective rate between two groups (P<0.05).Conclusion： Acupuncture combined with salmeterol was effective in controlling clinical symptoms of patients with acute exacerbation of BA, improving lung function, inhibiting body inflammatory response, and improving immunity. The curative effect is significantly better than that of salmeterol.

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更新日期/Last Update: 2018-11-30