[1]杨 青,屈 芳,高彩彩,等.通肺平哮汤辅助治疗对支气管哮喘急性发作期患儿外周血白三烯及血小板激活因子水平的影响*[J].陕西中医,2019,(12):1697-1700.
　YANG Qing,QU Fang,GAO Caicai,et al.Effects of Tongfei Pingxiao decoction adjuvant therapy on levels of leukotriene and platelet activating factors in peripheral blood of children with acute attack of bronchial asthma[J].,2019,(12):1697-1700.
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通肺平哮汤辅助治疗对支气管哮喘急性发作期患儿外周血白三烯及血小板激活因子水平的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年12期
页码:
1697-1700
栏目:
临床研究
出版日期:
2019-12-05

文章信息/Info

Title:
Effects of Tongfei Pingxiao decoction adjuvant therapy on levels of leukotriene and platelet activating factors in peripheral blood of children with acute attack of bronchial asthma
文章编号:
DOI:10.3969/j.issn.10007369.2019.12.011
作者:
杨 青1; 屈 芳1; 高彩彩1; 杨艳萍2△
1.长安医院儿科（西安 710016）;2.西安市第三医院儿科（西安 710018）
Author(s):
YANG Qing; QU Fang; GAO Caicai; et al.
Department of Pediatrics,Chang’an Hospital (Xi’an 710016)
关键词:
通肺平哮汤; 支气管哮喘急性发作期患儿; 白三烯; 血小板激活因子; 临床疗效研究
Keywords:
Key words Tongfei Pingxiao decoction; Child with acute attack of bronchial asthma; Leukotriene; Platelet activating factor; Clinical efficacy study
分类号:
R256.12
文献标志码:
A
摘要:
摘 要 目的：探究支气管哮喘急性发作期采用通肺平哮汤辅助治疗效果。方法：以103例支气管哮喘急性发作期患儿为对象，依据用药方式不同分为单纯西医组（n=46）与中西医组（n=57），依次采用西医与西医加通肺平哮汤治疗。比较两组治疗前后中医证候积分、疗效、治疗前后炎症因子、肺功能、治疗安全性。结果：两组治疗后哮鸣音、咳嗽、喘息、胸膈满闷以及咯痰等中医证候积分、总积分与治疗前比较均明显下降（P＜0.05），治疗后中西医组上述积分显著低于单纯西医组患者（P＜0.05）。中西医组治疗总有效率（94.74%）优于单纯西医组（78.26%），差异比较具有统计学意义（P＜0.05）。两组治疗后IL4、LT以及PAF水平较治疗前下降，INFγ水平较治疗前上升，差异比较具有统计学意义（P＜0.05），治疗后中西医组炎症因子水平变化幅度明显高于单纯西医组患者（P＜0.05）。两组治疗后FVC、PEF、FEV1、FEV1/FVC等肺功能指标较治疗前明显改善（P＜0.05），治疗后中西医组肺功能指标显著高于单纯西医组（P＜0.05）。两组不良反应发生率差异比较没有统计学意义（7.02%与12.50%，P＞0.05）。结论：支气管哮喘急性发作期患儿采用通肺平哮汤进行辅助治疗，可以明显下调LT与PAF水平，改善患儿肺功能，缓解患儿疾病相关症状。
Abstract:
Abstract Objective:To explore adjuvant therapy effect of Tongfei Pingxiao decoction on acute attack of bronchial asthma.Methods:Retrospective analysis was performed on related data of 103 children with acute attack of bronchial asthma.According to different medication methods,they were divided into single western medicine group (n=46) and Chinesewestern medicine group (n=57).The two groups were treated with western medicine and western medicine combined with Tongfei Pingxiao decoction,respectively.TCM syndromes scores,curative effect,inflammatory factors,lung function before and after treatment and therapeutic safety were compared between the two groups.Results:After treatment,scores of TCM syndrome such as wheezing rale,cough,wheezing,chestdiaphragm depression and expectoration,and total score in both groups were significantly decreased (P＜0.05).After treatment,the above scores in Chinesewestern medicine group were significantly lower than those in single western medicine group (P＜0.05).The total response rate of treatment in Chinesewestern medicine group was better than that in single western medicine group (94.74% vs 78.26%) (P＜0.05).After treatment,levels of IL4,LT and PAF in both groups were decreased,while INFγ level was increased (P＜0.05).After treatment,change amplitude of inflammatory factors levels in Chinesewestern medicine group was significantly higher than that in single simple western medicine group (P＜0.05).After treatment,pulmonary function indexes such as FVC,PEF,FEV1 and FEV1/FVC in both groups were significantly improved (P＜0.05).And the above indexes in Chinesewestern medicine group were significantly higher than those in single western medicine group (P＜0.05).There was no significant difference in the incidence of ADR between two groups (7.02% vs 12.50%,P＞0.05).Conclusion:Tongfei Pingxiao decoction adjuvant therapy for children with acute attack of bronchial asthma can significantly reduce levels of LT and〖LM〗 PAF,improve their pulmonary function,and alleviate diseaserelated symptoms.

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备注/Memo

备注/Memo:
*陕西省卫生和计划生育委员会科研项目（2014JM40256)
更新日期/Last Update: 2019-12-19