[1]单宇鹏,张 婕△.益气维血胶囊联合人重组促红素治疗肿瘤相关性贫血疗效及对患者Hepcidin、TFR2水平影响*[J].陕西中医,2019,(12):1717-1720.
　SHAN Yupeng,ZHANG Jie..Yiqi Weixue capsule combined with human recombinant erythropoietin on Hepcidin and TFR2 levels in patients with tumor associated anemia[J].,2019,(12):1717-1720.
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益气维血胶囊联合人重组促红素治疗肿瘤相关性贫血疗效及对患者Hepcidin、TFR2水平影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年12期
页码:
1717-1720
栏目:
临床研究
出版日期:
2019-12-05

文章信息/Info

Title:
Yiqi Weixue capsule combined with human recombinant erythropoietin on Hepcidin and TFR2 levels in patients with tumor associated anemia
文章编号:
DOI:10.3969/j.issn.10007369.2019.12.016
作者:
单宇鹏1; 张 婕2△
1.空军军医大学唐都医院肿瘤科（西安710038）；2.西安国际医学中心医院肿瘤科（西安 710118）
Author(s):
SHAN Yupeng; ZHANG Jie.
Department of Oncology, Tangdu Hospital of Air Force Military Medical University （Xi’an 710038）
关键词:
益气维血胶囊; 人重组促红素; 肿瘤相关性贫血; Hepcidin; TFR2; 临床疗效
Keywords:
Key words Yiqi Weixue capsule; EPO; Tumorassociated anemia; Hepcidin; TFR2; Clinical effect
分类号:
R273
文献标志码:
A
摘要:
摘 要 目的：探究益气维血胶囊联合人重组促红素（EPO）对肿瘤相关性贫血患者铁调素（Hepcidin）和转铁蛋白受体2（TFR2）水平的影响及其临床效果研究。方法：选取符合标准的112例患者纳入研究，随机分为对照组和研究组，每组56例。对照组使用EPO治疗，研究组在对照组基础上联合益气维血胶囊治疗。对照两组临床疗效、Hepcidin和TFR2水平。结果：治疗后两组红细胞计数（RBC）、血红蛋白（Hb）和平均血红蛋白浓度（MCHC）均明显升高，研究组各指标分别为（4.27±0.74）×1012/L、（91.25±10.02）g/L和（314.5±13.76）g/L，其变化幅度较对照组更大且更趋于正常值（P＜005）。治疗后两组患者Hepcidin、TFR2、铁幼素（HJV）和膜铁转运蛋白（FPN）均明显改变，研究组治疗后各指标水平分别为（2.03±1.25）ng/ml、（6.95±1.33）ng/ml、（0.91±0.40）ng/ml和（2.21±0.68）ng/ml，其变化趋势较对照组更明显（P＜005）。对照组有效率为85.71%，明显低于研究组的94.64%（P＜005）。研究和对照组均出现血压上升、低热、困乏和恶心呕吐现象，总发生率分别为10.71%和12.40%，无统计学差异（P＞005）。结论：益气维血胶囊联合EPO治疗肿瘤相关性贫血疗效显著，可有效改善Hepcidin和TFR2水平，同时不增加副反应发生率，安全性较好。
Abstract:
Abstract Objective:To investigate the effect of Yiqi Weixue capsule combined with human recombinant erythropoietin (EPO) on the levels of Hepcidin and transferrin receptor 2(TFR2) in patients with tumorassociated anemia and its clinical effect. Methods:112 patients who met the criteria were selected. They were randomly divided into control group and research group,56 patients in each group. The control group was treated with EPO,while the study group was treated with Yiqi Weixue capsule on the basis of the control group. The clinical efficacy,Hepcidin and TFR2 levels of the two groups were compared. Results:After treatment,the red blood cell count (RBC),hemoglobin (Hb) and mean hemoglobin concentration (MCHC) were significantly increased in both groups. The indicators of the study group were (4.27±0.74)×1012/L,(91.25±10.02) g/L and (314.5±13.76) g/L. The change range of study group was larger than the control group and more normal (P＜005). After treatment,hepcidin,TFR2,ferritin (HJV) and ferroportin (FPN) were significantly altered in both groups. The levels of the indicators in the study group were (2.03±1.25) ng/ml,(6.95±1.33) ng/ml,(0.91±0.40) ng/ml,and (2.21±0.68) ng/ml,respectively. The change trend of study group was more obvious than the control group (P＜005). The effective rate of the control group was 85.71%,which was significantly lower than the 94.64% of the study group (P＜005). Both the study and the control group showed elevated blood pressure,low fever,sleepiness,and nausea and vomiting. The total incidence was 10.71% and 12.40%,respectively,no significant difference (P＞005). Conclusion:Yiqi Weixue capsule combined with EPO is effective in the treatment of tumorrelated anemia. It can effectively improve the levels of Hepcidin and TFR2 without increasing the incidence of side effects. It is safe and effective,and 〖LM〗is worthy of clinical treatment choice.

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备注/Memo

备注/Memo:
*陕西省社会发展科技攻关项目(2012SF2113)
更新日期/Last Update: 2019-12-19