[1]张哓红,康梅娟.温胆益脑汤联合左旋多巴对老年帕金森患者认知功能 及血清脑源性神经营养因子水平的影响[J].陕西中医,2019,(2):178-181.
　ZHANG Xiaohong,KANG Meijuan..Effect of Wendan Yinao decoction combined with levodopa on cognitive function and serum brainderived neurotrophic factor levels in elderly patients with Parkinson’s disease[J].,2019,(2):178-181.
点击复制

温胆益脑汤联合左旋多巴对老年帕金森患者认知功能 及血清脑源性神经营养因子水平的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年2期
页码:
178-181
栏目:
临床研究
出版日期:
2019-02-05

文章信息/Info

Title:
Effect of Wendan Yinao decoction combined with levodopa on cognitive function and serum  brainderived neurotrophic factor levels in elderly patients with Parkinson’s disease
文章编号:
DOI: 10.3969/j.issn.10007369.2019.02.011
作者:
张哓红1 ; 康梅娟2
1.郑州大学附属洛阳中心医院神经内科（洛阳 471000）；2.河南省南阳市中心医院神经内科（ 南阳 473000）
Author(s):
ZHANG Xiaohong; KANG Meijuan.
Department of Neurology，Luoyang Central Hospital，Zhengzhou University (Luoyang 471000 )
关键词:
老年; 帕金森; 左旋多巴; 温胆益脑汤; 认知功能; 脑源性神经营养因子
Keywords:
Key words Old age; Parkinson’s; Levodopa; Wendan Yinao decoction; Cognitive function; Brainderived neurotrophic factor
分类号:
R742.5
文献标志码:
A
摘要:
摘 要 目的：研究温胆益脑汤联合左旋多巴对老年帕金森（PD）患者认知功能及血清脑源性神经营养因子（BDNF）水平的影响。方法：选取老年PD患者106例作为研究对象，按照治疗方案不同分组，各53例。对照组采取左旋多巴治疗，观察组采取温胆益脑汤加左旋多巴治疗。比较两组治疗效果、治疗前后蒙特利尔认知功能评估量表（MoCA）评分、简易状态检查量表（MMSE）评分、相关血清因子\[血清白介素1β（IL1β）、人软骨糖蛋白39（YKL40）、BDNF水平\]、生活质量核心量表（QOLC30）评分及不良反应发生情况。结果：治疗效果比较,观察组总有效率90.57%较对照组73.58%高（P＜0.05）；认知功能：观察组治疗8周后MoCA、MMSE评分较对照组高（P＜0.05）；相关血清因子：观察组治疗8周后血清BDNF水平较对照组高，IL1β、YKL40水平较对照组低（P＜0.05）；生活质量：治疗后1个月，观察组心理功能、躯体功能、社会功能评分较对照组高（P＜0.05）；不良反应：观察组不良反应发生率5.66%较对照组20.75%低（P＜0.05）。结论：温胆益脑汤联合左旋多巴治疗老年PD患者，疗效显著，可减轻病情程度及神经功能损伤，改善患者认知功能，提高生活质量，且能减少不良反应的发生。
Abstract:
Abstract Objective :To study the effects of Wendan Yinao decoction combined with levodopa on cognitive function and serum brainderived neurotrophic factor (BDNF) levels in elderly patients with Parkinson’s disease (PD). Methods: A total of 106 elderly patients with PD were enrolled. According to different treatment groups，53 patients were included. The control group was treated with levodopa，and the observation group was treated with Wendan Yinao decoction with levodopa. The effects of the two groups were compared，before and after treatment，the Montreal cognitive function assessment scale (MoCA) score，the Simple state examination scale (MMSE) score，and related serum factors \[serum IL1β (IL1β)，human cartilage glycoprotein 39 ( YKL40)，BDNF level\]，quality of life core scale (QOLC30) score and adverse reactions were counted. Results:Therapeutic effect: the total effective rate of the observation group was 90.57% higher than that of the control group (P＜0.05). Cognitive function: the MoCA and MMSE scores of the observation group were higher than those of the control group after 8 weeks of treatment (P＜0.05). Relevant serum factors: the serum BDNF level in the observation group was higher than that in the control group after 8 weeks of treatment，and the levels of IL1β and YKL40 were lower than those in the control group (P＜0.05). Quality of life: after 1month treatment，the psychological function，physical function and social function score of the observation group were higher than those of the control group (P＜0.05). Adverse reactions: the incidence of adverse reactions in the observation group was 5.66% lower than that in the control group (P＜0.05). Conclusion :Wendan Yinao decoction combined with levodopa in the treatment of elderly PD patients has significant curative effect，which can reduce the degree of disease and neurological damage，significantly improve cognitive function，improve quality of life，and significantly reduce the incidence of adverse reactions. 

参考文献/References:

\[1\] Pettorruso M,Martinotti G,Fasano A,et al.Anhedonia in Parkinson’s disease patients with and without pathological gambling:A casecontrol study[J] .Psychiatry Res,2014,215(2):448452.
[2] Lee YH,Song G G.BDNF 196 G/A and 270 C/T polymorphisms and susceptibility to Parkinson’s disease: a metaanalysis[J] .J Mot Behav,2014,46(1):5966.
[3] 中华医学会神经病学分会帕金森病及运动障碍学组.中国帕金森病治疗指南：第三版[J] .中华神经科杂志,2014,47(6):428433.
[4] 杨文明,鲍远程,汪 瀚,等.颤病(帕金森病)诊疗方案[J] .中医药临床杂志,2012,24(11):11251126.
[5] 何剑波,李会琪,翟洁敏,等.复方左旋多巴制剂与帕金森病患者同型半胱氨水平及认知损害的相关性分析[J] .陕西医学杂志,2017,46(2):250252.
[6] 闻公灵,温昌明,王彦平,等.左旋多巴联合恩他卡朋治疗帕金森病的临床研究[J] .中国临床药理学杂志,2016,32(14):12891292.
[7] 吕 姣.普拉克索联合左旋多巴治疗帕金森病疗效及安全性研究[J] .临床军医杂志,2017,45(1):5355.
[8] 赵亚明,胡 琦.天麻钩藤颗粒联合左旋多巴治疗帕金森病的疗效观察[J] .现代药物与临床,2017,32(3):403406.
[9] 李 琼,李楠楠,朱 洁.神经节苷脂联合左旋多巴治疗帕金森病的机制研究[J] .海南医学院学报,2016,22(23):28332836.〖ZK)〗
[10] 吴文涛,唐晓刚,王晓勇,等.中医辨证联合多巴丝肼治疗中晚期帕金森病的疗效观察[J] .陕西中医,2016,37(6):685686.
[11] 戴 军,罗亚明,曹雄彬,等.温胆益脑汤联合多巴丝肼对老年帕金森病人血清YKL40、IL1β、BDNF的影响[J] .中西医结合心脑血管病杂志,2018,16(9):12691272.
[12] 李鹏英,俞年军,李 勇,等.半夏在神经系统疾病中应用的研究进展[J] .中国现代中药,2016,18(3):390395.
[13] 黄传君,赵方正,张才擎.生地黄有效成分梓醇药理作用机制研究进展[J] .上海中医药杂志,2017,51(2):9397.
[14] 张翠英,章 洪,戚琼华.川芎的有效成分及药理研究进展[J] .辽宁中医杂志,2014,23(10):22642266.
[15] 陈宝友,李 强,刘 爱,等.帕金森病患者血清中脑源性神经营养因子、可溶性肿瘤坏死因子受体1和S100B的表达及意义[J] .中国老年学杂志,2015,35(4):931932.
[16] 叶心国,李 涛,李 翔,等.帕金森病患者血清EGF和BDNF水平变化与认知障碍的关系[J] .脑与神经疾病杂志,2016,24(7):406409.
[17] 成晓华,刘 斌,马原源,等.咪多吡对帕金森病模型大鼠黑质炎性因子TNFα、IL1β、IFNγ表达的影响[J] .免疫学杂志,2014,30(8):671676.
[18] KidoJ,Bando Y,Bando M,et al.YKL40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes[J] .Oral Dis,2015,21(5):667673.

相似文献/References:

[1]杨文佳,张华海,谢福恒.滋水涵木方联合多巴丝肼片治疗肝肾亏虚型帕金森病临床研究*[J].陕西中医,2019,(8):1021.
　YANG Wenjia,ZHANG Huahai,XIE Fuheng..Clinical observation on cognitive function of patients with Parkinson's disease of liver and kidney deficiency by Zishui Hanmu prescription combined with dopazide tablets[J].,2019,(2):1021.
[2]尚磊,李映雪△.补肾通痹汤联合雷公藤多苷治疗老年类风湿关节炎疗效研究*[J].陕西中医,2019,(11):1552.
　SHANG Lei,LI Yingxue..Effect of Bushen Tongbi decoction combined with tripterygium wilfordii polyglycosides in the treatment of eldery rheumatoid arthritis[J].,2019,(2):1552.

更新日期/Last Update: 2019-03-13