[1]王清亮,陆文杰,陈咸川.益气活血化痰通络方对颈动脉粥样硬化患者T细胞亚群影响的研究[J].陕西中医,2019,(3):307-310.
　WANG Qingliang,LU Wenjie,CHEN Xianchuan..Effect of Yiqi Huoxue Huatan Tongluo formula on Tcells subset in patients with carotid atherosclerosis[J].,2019,(3):307-310.
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益气活血化痰通络方对颈动脉粥样硬化患者T细胞亚群影响的研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年3
页码:
307-310
栏目:
临床研究
出版日期:
2019-03-05

文章信息/Info

Title:
Effect of Yiqi Huoxue Huatan Tongluo formula on Tcells subset in patients with carotid atherosclerosis
文章编号:
DOI: 10.3969/j.issn.10007369.2019.03.010
作者:
王清亮1; 陆文杰2; 陈咸川1
1.上海中医药大学附属岳阳中西医结合医院（上海 200437）;〖JZ〗2. 上海中医药大学附属岳阳中西医结合医院崇明分院（上海 202150）
Author(s):
WANG Qingliang;  LU Wenjie; CHEN Xianchuan.
Yueyang Hospital of Integrative Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine（Shanghai 200437）
关键词:
动脉粥样硬化; 益气活血化痰通络方; 疗效比较研究; 颈动脉; T细胞亚群; 方剂
Keywords:
Key words Atherosclerosis; Yiqi Huoxue Huatan Tongluo formula; Comparative effectiveness research; Carotid artery; Tcells subset; Formular
分类号:
R543.1
文献标志码:
A
摘要:
摘 要 目的：观察益气活血化痰通络方对颈动脉粥样硬化患者T细胞亚群的影响。方法： 将61例诊断为颈动脉粥样硬化且中医辨证为气虚痰瘀证的老年患者（年龄≥60岁）随机分为治疗组（益气活血化痰通络方每日1剂加阿托伐他汀20 mg/d）与对照组(阿托伐他汀20 mg/d)，治疗周期为12周。用药前后，观察两组T细胞亚群、血脂及中医证候的变化。结果:两组具有基线同质性，治疗12周后，治疗组中医证候改善优于对照组（P＜0.01）。治疗组低密度脂蛋白低于对照组（P＜0.05）。治疗组Th细胞、Th/Ts、NK细胞低于对照组（P＜0.05）。治疗前后，两组患者血常规、肝功能、肾功能等安全指标未出现明显异常。结论：益气活血化痰通络方可以调节颈动脉粥样硬化患者的T细胞亚群水平，其作用机制可能与改善炎症反应有关。
Abstract:
Abstract Objective：To observe the Tcells subset of patients with carotid atherosclerosis after treatment of Yiqi Huoxue Huatan Tongluo formula. Methods：61 patients with carotid atherosclerosis of which TCM syndrome were Qi deficiency and sputum stasis(age≥60) were randomly divided into control group(atorvastatin 20 mg/d) and treatment group(Yiqi Huoxue Huatan Tongluo Fang plus with atorvastatin 20 mg/d). The duration of therapy was 12 weeks. The Tcells subset, blood lipid levels and TCM syndrome score were observed before and after 12week treatment. Results：The two groups had baseline homogeneity. After 12week treatment, the TCM syndrome response to therapy was better than control group(P＜0.01). The LDL of treatment group was lower than control group(P＜0.05). The Th cells, Th/Ts and NK cells of treatment group were lower than control group(P＜0.05). There were no statistical differences in blood routine examination, liver function and renal function. Conclusion： Yiqi Huoxue Huatan Tongluo formula can regulate Tcells subset level patients with carotid atherosclerosis, which mechanism was concerned with improving inflammatory response.

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更新日期/Last Update: 2019-03-13