[1]景凤英,国福云.补中益气汤加味治疗肠结核临床研究*[J].陕西中医,2019,(4):496-498.
　JING Fengying,GUO Fuyun..Clinical analysis of Buzhong Yiqi decoction in treating intestinal tuberculosis[J].,2019,(4):496-498.
点击复制

补中益气汤加味治疗肠结核临床研究*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年4期
页码:
496-498
栏目:
临床研究
出版日期:
2019-04-05

文章信息/Info

Title:
Clinical analysis of Buzhong Yiqi decoction in treating intestinal tuberculosis
文章编号:
DOI:10.3969/j.issn.10007369.2019.04.028
作者:
景凤英; 国福云
陕西省结核病防治院(陕西省第五人民医院)（西安 710100）
Author(s):
JING Fengying; GUO Fuyun.
Shaanxi Tuberculosis Control Hospital(Shaanxi Fifth People’s Hospital）(Xi’an 710100)
关键词:
补中益气汤; 肠结核; 细胞亚群; 血清C反应蛋白; 肠道炎症因子; 安全性
Keywords:
Key words Buzhong Yiqi decoction; Intestinal tuberculosis; T cell subsets; Serum Creactive protein ; Intestinal inflammatory factors; Safety
分类号:
R524
文献标志码:
A
摘要:
摘 要 目的：分析研究补中益气汤加味对肠结核患者的临床疗效。方法：选取肠结核患者80例按照随机双盲的原则均分为对照组和研究组。两组患者入院后均进行基础治疗，对照组40例采用常规四联抗结核药物治疗，研究组40例加用补中益气汤治疗，对两组患者治疗效果、不良反应发生率及治疗前后肠道炎症因子、肠黏膜屏障功能及T细胞亚群指标进行比较。结果：研究组的临床总有效率和不良反应发生率分别为92.50%（37/40）、15.00%（6/40），对照组分别为72.50%（29/40）、40.00%（16/40），差异均具有统计学意义（P＜0.05）。治疗前，CD3＋、CD4＋、CD8＋无明显差异（P＞0.05），治疗后，研究组患者CD3＋、CD4＋水平均明显高于对照组， 而CD8＋水平明显低于对照组（P＜0.05）；治疗后，研究组患者血清C反应蛋白（CRP）水平和血清肿瘤坏死因子α（TNFα）及白介素10（IL10）水平均明显低于对照组，血D乳酸和血二胺氧化酶（DAO）水平也明显低于对照组，差异具有统计学意义（P＜0.05）。结论：肠结核患者在常规治疗的基础上加用补中益气汤加味治疗有助于改善患者的肠道屏障功能和T细胞亚群的免疫功能，缓解对机体肠道的损伤，疗效确切。
Abstract:
Abstract Objective：To analyze the clinical effect of Buzhong Yiqi decoction on patients with intestinal tuberculosis. Methods：Eighty patients with intestinal tuberculosis were selected and divided into control group and study group according to the principle of random doubleblind. The two groups of patients underwent basic treatment after admission. 40 patients in the control group were treated with conventional fourdrug therapy，and 40 patients in the study group were treated with Buzhong Yiqi decoction. The treatment effect and adverse reactions occurred in the two groups. The rates were compared with those of intestinal inflammatory factors，intestinal mucosal barrier function and T cell subsets before and after treatment. Results：The total clinical effective rate and adverse reaction rate of the study group were 92.50% (37/40) and 15.00% (6/40)，respectively. The control group was 72.50% (29/40) and 40.00% (16/40)，respectively. The differences were statistically significant (P＜0.05). After treatment，the levels of CD3+ and CD4+ in the study group were significantly higher than those in the control group，while the level of CD8+ was significantly lower than that in the control group (P＜0.05). The levels of CRP and TNFα and IL10 in the study group were significantly lower than those in the control group，and blood Dlactic acid and blood diamine were oxidized. The level of enzyme (DAO) was also significantly lower than that of the control group，and the difference was significant (P＜0.05). Conclusion:The addition of Buzhong Yiqi decoction on the basis of conventional treatment of intestinal tuberculosis patients is more helpful to improve the intestinal barrier function and immune function of T cell subsets，and to alleviate the damage to the intestinal tract of the body.

参考文献/References:

[1] Silva DR，Gazzana MB，Dalcin PT.Severe tuberculosis requiring ICU admission [J].J Bras Pneumol，2012，38(3):386394.
[2] 叶丽敏，李 岚，白班俊.T细胞斑点试验在肠结核及克罗恩病鉴别诊断中的临床价值 [J].第三军医大学学报，2015，37(20):20912095.
[3] Mosquera KG，HolguinCardona A.Endoscopic closure of tracheoesophageal fistula for tuberculosis with an overthescopeclip [J].Rev Esp Enferm Dig，2018，110(9):594596.
[4] 吉鹏飞，杨红燕.肠结核的临床特点及误诊分析 [J].包头医学院学报，2015，31(5):9697.
[5] 周 贝，吕佳康.《中药新药治疗流行性感冒临床研究技术指导原则》解读 [J].中国临床药理学杂志，2017，33(14):13821384.
[6] 胡华建，李中跃，詹 学，等.反复黏液血便伴弥漫性大肠病变的儿童肠结核1例 [J].第三军医大学学报，2015，37(2):175177.
[7] 毛 华，丘文丹.克罗恩病与肠结核临床、内镜及病理特征对比分析 [J].胃肠病学和肝病学杂志，2014，23(1):7577.
[8] 张 怡，李 兵，李美月.临床药师参与肾移植术后合并肠结核患者抗结核治疗的药学实践 [J].中国医院用药评价与分析，2017，17(7):985988.
[9] 王 勋.肠结核与原发性小肠淋巴瘤的临床、内镜及CT特点的分析 [J].现代中西医结合杂志，2014，23(27):30353036，3049.〖ZK）〗
[10] 李 莉，张 建，白 婕，等.外科治疗36例伴严重并发症的肠结核 [J].中国中西医结合外科杂志，2014，20(6):619621.
[11] 刘贤宁,陈 弢,王天平,等.肠结核致肠穿孔12例诊治体会 [J].陕西医学杂志,2012,41(10):14071408.
[12] Kim JH，Kim SH，Choi JI，et al.Atypical noncontiguous multiple spinal tuberculosis:a case report [J].Korean J Spine,2014，11(2):7780.
[13] 彭 湃，杜 舟，韩少良，等.直肠癌合并直肠结核一例 [J].中华普通外科杂志,2014，29(11):881.

相似文献/References:

[1]李云攀,施弘,洪梅.补中益气汤联合穴位贴敷治疗老年慢性便秘疗效观察[J].陕西中医,2017,(06):767.
[2]宁博彪,李宝花,王晓玲,等.以“从肝论治”角度论补中益气汤*[J].陕西中医,2019,(11):1608.
　NING Bobiao,LI Baohua,WANG Xiaoling,et al.Study of effects of Buzhong Yiqi decoction on treatment of liver[J].,2019,(4):1608.
[3]陈诗园,董明国△,吴意红.补中益气汤联合耳穴贴压对消化道肿瘤癌因性疲乏患者免疫功能及血清皮质醇的影响*[J].陕西中医,2020,(9):1241.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.018]
　CHEN Shiyuan,DONG Mingguo,WU Yihong..Effect of Buzhong Yiqi decoction combined with auricular point sticking on immune function and serum cortisol in patients with cancer related fatigue in digestive tract tumors[J].,2020,(4):1241.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.018]
[4]刘进娜,张婵娟,李 娜.补中益气汤调控JAK2/STAT3信号通路对气虚发热证大鼠肠道菌群、免疫功能及神经功能的影响[J].陕西中医,2023,(5):571.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.006]
　LIU Jinna,ZHANG Chanjuan,LI Na.Effects of Buzhong Yiqi decoction on the regulation of JAK2/STAT3 signaling pathway on intestinal flora,immune function and neurological function in rats with Qi deficiency fever[J].,2023,(4):571.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.006]

备注/Memo

备注/Memo:
*陕西省卫生科研基金资助项目（2016D06410）
更新日期/Last Update: 2019-04-24