[1]张金李,韩 鹏,王曜宇.养心通脉汤治疗冠脉支架植入术后再狭窄疗效 及对患者血清肿瘤坏死因子-α和C反应蛋白的影响[J].陕西中医,2019,(5):572-575.
　ZHANG Jinli,HAN Peng,WANG Yaoyu..Effect of Yangxin Tongmai decoction on restenosis after coronary stent implantation and its effect on serum TNF-α and CRP[J].,2019,(5):572-575.
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养心通脉汤治疗冠脉支架植入术后再狭窄疗效 及对患者血清肿瘤坏死因子-α和C反应蛋白的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年5期
页码:
572-575
栏目:
临床研究
出版日期:
2019-05-05

文章信息/Info

Title:
Effect of Yangxin Tongmai decoction on restenosis after coronary stent implantation and its effect on serum TNF-α and CRP
文章编号:
DOI:〖HT5K〗10.3969/j.issn.1000-7369.2019.05.008
作者:
张金李 1 ;  韩 鹏 2 ; 王曜宇
1.河南省开封市中心医院检验科(开封 475000)；2.河南省开封市鼓楼区医院中医科 (开封 475000)
Author(s):
ZHANG Jinli;  HAN Peng; WANG Yaoyu.
Department of Laboratory,Kaifeng Central Hospital（Kaifeng 475000）
关键词:
养心冠脉汤;  冠脉支架植入术;  阿司匹林肠溶片; 再狭窄; 肿瘤坏死因子-α; C反应蛋白
Keywords:
Yangxin Guanmai decoction;  coronary stenting;  aspirin enteric-coated tablets; restenosis;  CRP; TNF-α
分类号:
R541.4
文献标志码:
A
摘要:
摘 要 目的：探究养心冠脉汤对冠脉支架植入术患者再狭窄的治疗效果，分析其对患者血清TNF-α（肿瘤坏死因子-α）和CRP（C反应蛋白）的影响。方法：选取行冠脉支架介入术治疗的患者60例，采用随机数字表法分成治疗组30例和对照组30例。对照组采用阿司匹林肠溶片、氯吡格雷片、阿托伐他汀钙片等药物治疗，治疗组在对照组的治疗基础上加用养心通脉汤口服治疗，所有患者均治疗6个月。统计两组患者再发生冠脉狭窄的比例、中医证候疗效、心电图疗效，及治疗前后血清TNF-α水平、CRP水平、血脂水平。结果：治疗组患者冠脉再狭窄比例较对照组显著降低，差异具有统计学意义（P<0.05）。治疗组患者LDL-C（低密度脂蛋白胆固醇）、TG（甘油三酯）、TC（总胆固醇）水平显著低于低于对照组（P<0.05），HDL-C（高密度脂蛋白胆固醇）较对照组显著提高，差异具有统计学意义（P<0.05）。治疗组中医证候疗效总有效率显著高于对照组，差异具有统计学意义（P<0.05）。治疗组心电图疗效总有效率显著高于对照组，差异具有统计学意义（P<0.05）。治疗组患者TNF-α和CRP水平较对照组显著降低，差异具有统计学意义（P<0.05）。结论： 养心通脉汤能有效降低冠脉支架植入术后再狭窄的发生率，改善血脂水平、心电图和中医证候，并降低血清内CRP水平和TNF-α水平。
Abstract:
Abstract Objective:To explore the therapeutic effect of Yangxin Guanmai decoction on restenosis in patients undergoing coronary stenting, and to analyze its effect on serum TNF-α (tumor necrosis factor-α) and CRP (C-reactive protein).Methods:Sixty patients who underwent coronary stenting were enrolled. The patients were divided into treatment group (30 cases) and control group (30 cases) by random number table. The control group was treated with aspirin enteric-coated tablets, clopidogrel tablets, and atorvastatin calcium tablets. The treatment group was treated with Yangxin Tongmai decoction on the basis of the treatment of the control group. All patients were treated for 6 months. The proportion of recurrent coronary stenosis, TCM syndrome efficacy, electrocardiogram efficacy, serum TNF-α level, CRP level and blood lipid level before and after treatment were counted.Results:The proportion of coronary restenosis in the treatment group was significantly lower than that in the control group and the difference was statistically significant（P<0.05）.The levels of LDL-C (low-density lipoprotein cholesterol), TG (triglyceride), and TC (total cholesterol) in the treatment group were significantly lower than those in the control group (P<0.05), HDL-C (high-density lipoprotein cholesterol). The difference was significantly higher than the control group was statistically significant（P<0.05）.The total effective rate of TCM syndromes in the treatment group was significantly higher than that in the control group and the difference was statistically significant（P<0.05）. The total effective rate of electrocardiogram in the treatment group was significantly higher than that in the control group and the difference was statistically significant（P<0.05）.The levels of TNF-α and CRP in the treatment group were significantly lower than those in the control group and the difference was statistically significant（P<0.05）.Conclusion:Yangxin Tongmai decoction can effectively reduce the incidence of restenosis after coronary stent implantation, improve blood lipid levels, electrocardiogram and TCM syndrome, and reduce serum CRP levels and TNF-α levels.

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更新日期/Last Update: 2019-05-07