[1]贺 辉,刘正艳,梁丽娜,等.宣肺清毒汤治疗小儿支原体肺炎疗效及对患者血清炎性因子表达水平的研究[J].陕西中医,2019,(5):627-630.
　HE Hui,LIU Zhengyan,LIANG Lina,et al.Effect of Xuanfei Qingdu decoction on children of mycoplasma pneumonia and its influence on expression level of serum inflammatory factors[J].,2019,(5):627-630.
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宣肺清毒汤治疗小儿支原体肺炎疗效及对患者血清炎性因子表达水平的研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年5期
页码:
627-630
栏目:
临床研究
出版日期:
2019-05-05

文章信息/Info

Title:
Effect of Xuanfei Qingdu decoction on children of mycoplasma pneumonia and its influence on expression level of serum inflammatory factors
文章编号:
DOI:〖HT5K〗10.3969/j.issn.1000-7369.2019.05.024
作者:
贺 辉 1 ;  刘正艳 1 ; 梁丽娜 1 ; 闫永彬 2 ; 王 勤
1.河南省信阳市中医院儿科（信阳464000）； 2.河南中医药大学第一附属医院儿科 （郑州450008）； 3.河南省中医院儿科（郑州 450000）
Author(s):
HE Hui; LIU Zhengyan; LIANG Lina; et al.
Department of Pediatrics, Xinyang Traditional Chinese Medicine Hospital（Xinyang 464000）
关键词:
肺炎支原体肺炎; 儿童; 肺功能; 超敏C反应蛋白; 白细胞介素-6; 肿瘤坏死因子
Keywords:
Mycoplasma pneumoniae;  Child; Lung function;  Hypersensitive c-reactive protein;  Interleukin-6;  Tumor necrosis factor
分类号:
R725.6
文献标志码:
A
摘要:
摘 要 目的：观察自拟宣肺清毒汤治疗小儿支原体肺炎的疗效及对患儿血清炎性因子表达水平的影响。方法：选取94例肺炎支原体肺炎患儿纳入本次研究，将入选患儿以随机数字表法进行均分，分别纳入对照组与观察组，对照组给予阿奇霉素序贯治疗，观察组在对照组的基础上给予宣肺清毒汤治疗；治疗1个疗程后，评估两组临床疗效，观察患儿症状与体征消失时间，对比治疗前、后两组患儿血清炎性因子、肺功能指标变化情况。结果：观察组整体疗效水平优于对照组（P<0.05）；观察组患儿发热、咳嗽、喘息、肺部干湿啰音的消失时间，肺炎支原体抗体Ig-M转阴时间均少于对照组（P<0.05）；治疗后，两组患儿hs-CRP、TNF-α、IL-6表达水平均较本组治疗前改善（P<0.05），且观察组各项炎性因子表达水平均低于对照组（P<0.05）；治疗后，两组患儿的RR、PaO2 /FiO2 、FVC、MMF、PEF均较本组治疗前改善（P<0.05），且观察组各项肺功能指标均优于对照组（P<0.05）。结论：宣肺清毒汤治疗小儿支原体肺炎疗效理想，能够进一步降低炎性因子表达水平，改善患儿肺功能并可促进患儿症状体征消失。
Abstract:
Abstract Objective ：To observe the curative effect of Xuanfei Qingdu decoction in the treatment of children with mycoplasma pneumonia and its influence on expression level of serum inflammatory factors. Methods：A total of 94 children with mycoplasma pneumonia were enrolled. All patients were randomly divided into 2 groups, 47 cases in each group. The control group was treated with azithromycin sequential therapy, and the observation group was treated with Xuanfei Qingdu decoction on the basis of control group. The clinical efficacy, disappeared time of symptoms and signs, changes of serum inflammatory factors levels and pulmonary function indexes were compared before and after one course of treatment. Results：The effective rate of the observation group was significantly higher than that of the control group (P<0.05). The disappearance time of high fever, cough, wheezing, lung dry, wet sputum and mycoplasma pneumoniae antibody Ig-M negative time in the observation group were shorter than those in the control group (all P<0.05). After treatment, the expression levels of hs-CRP, TNF-αand IL-6 in 2 groups of children were significantly improved compared with those before treatment (all P<0.05), and the observation group were lower than those in the control group (P<0.05). RR, PaO2 /FiO2 , FVC, MMF and PEF in 2 groups of children were significantly improved compared with those before treatment (all P<0.05), and the observation group was better than those in the control group (P<0.05). Conclusion ：Xuanfei Qingdu decoction is effective in treatment of children with mycoplasmal pneumonia. It can reduce the expression level of inflammatory factors, improve the pulmonary function, and promote the early disappearance of symptoms and signs.

参考文献/References:

[1] 王炳征,陈 玺,毛云英.小儿难治性肺炎支原体肺炎78例临床诊治分析 [J].陕西医学杂志,2017,46(5):567-568,571.
[2] 边红恩,陈团营,单海军.加味五虎汤联合阿奇霉素治疗痰热闭肺型小儿支原体肺炎疗效及对T淋巴细胞亚群的影响 [J].中国实验方剂学杂志,2018,24(2):164-169.
[3] Chen FQ,Yang YZ,Yu LL,et al.Prevalence of mycoplasma pneumonia:A case for community-acquired infection among pediatric population [J].Nigerian Journal of Clinical Practice,2015,18(3):354-358.
[4] 陈丽珠,陈杰奎.桑杏汤联合阿奇霉素治疗小儿支原体肺炎临床疗效观察 [J].中药药理与临床,2015,31(4):216-218.
[5] 陆丽骏,乔晓辉,李保法,等.阿奇霉素联合转移因子口服溶液治疗小儿支原体肺炎的疗效及对肺功能的影响研究 [J].中华医院感染学杂志,2018,28(7):1100-1103.
[6] 吴华启.小儿难治性支原体肺炎甲泼尼龙联合阿奇霉素治疗的效果与安全性评价 [J].辽宁医学杂志,2018,32(4):37-39.
[7] 诸福棠,胡亚美,江载芳.诸福棠实用儿科学 [M].北京:人民卫生出版社,2002:1185-1204.
[8] 国家中医药管理局.中医病证诊断疗效标准\[S\].南京:南京大学出版社,1995:78-78.
[9] 国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:158.
[10] 姜之炎,王雪峰,王力宁,等.小儿肺炎支原体肺炎多中心流行性特征分析 [J].中华中医药杂志,2018,33(1):376-379.
[11] 韩晓虹,陆晓丹,符 青.小儿消积止咳口服液联合阿奇霉素治疗小儿支原体肺炎 [J].辽宁中医杂志,2018,45(3):551-553.
[12] 荣 毅,王 蕾,刘志国.益气养阴、清热活血法治疗小儿重症肺炎支原体肺炎合并肺不张 [J].中医杂志,2018,59(16):1426-1428.
[13] 雷 辉,邵荣昌.玉屏风颗粒联合痰热清、阿奇霉素治疗小儿支原体肺炎临床观察 [J].陕西中医,2017,38(5):631-633.
[14] 陈团营,朱 珊,边红恩,等.连花清瘟颗粒对小儿肺炎支原体肺炎肺功能指标、血清炎症因子水平影响及疗效分析 [J].中华中医药学刊,2018,36(11):2713-2715.
[15] 边红恩,陈团营,单海军.麻杏石甘汤联合阿奇霉素对小儿支原体肺炎患者抗炎、促炎因子及免疫功能的影响 [J].中国实验方剂学杂志,2017,23(22):177-181.
[16] 陈 恒,吴云刚.不同剂量甲强龙联合阿奇霉素治疗小儿肺大叶实变性重症支原体肺炎的临床疗效观察 [J].中国药学杂志,2018,53(20):1799-1802.

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更新日期/Last Update: 2019-05-07