[1]崔小丽,山 媛,蒋 锋,等.脑血疏口服液治疗血管性认知功能障碍临床研究*[J].陕西中医,2019,(8):1018-1020.
　CUI Xiaoli,SHAN Yuan,JIANG Feng,et al.Effect observation on vascular cognitive impairment treated by Naoxueshu oral liquid[J].,2019,(8):1018-1020.
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脑血疏口服液治疗血管性认知功能障碍临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1018-1020
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Effect observation on vascular cognitive impairment treated by Naoxueshu oral liquid
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.08.009
作者:
崔小丽; 山 媛; 蒋 锋; 赵 瑞; 王 莉; 陈晓莉 △
陕西省人民医院（西安 710068）
Author(s):
CUI Xiaoli; SHAN Yuan; JIANG Feng; et al.
Department of Neurology,Shaanxi People’s Hospital（Xi’an 710068）
关键词:
血管性认知功能障碍; 脑血疏口服液; 尼莫地平; 红细胞压积; 纤维蛋白原; 血浆比粘度
Keywords:
Key words Vascular cognitive impairment; Naoxueshu oral liquid; Nimodipine; Hematocrit; Fibrinogen; Plasma specific viscosity
分类号:
R741
文献标志码:
A
摘要:
摘 要 目的： 观察脑血疏口服液对血管性认知功能障碍（VCI）患者的临床疗效及对认知功能影响。方法：选取VCI患者80例，随机分为两组各40例，治疗组给予脑血疏口服液，每次10 ml，3次/d，对照组给予尼莫地平，每次30 mg，3次/d，为期6个月，分别于治疗前后对认知能力、日常生活能力进行评价，并检测两组患者的血液粘度，统计不良反应发生率。结果： 治疗后1月、3月、6月两组简易精神状态量表（MMSE）、日常生活活动能力量表（ADL）评分均较治疗前有显著提高，差别有统计学意义（P＜0.05），治疗后1个月，治疗组和对照组比较，差别无统计学意义（P＞0.05），治疗后3个月、6个月治疗组MMSE、ADL评分较对照组提高明显，两组比较差异有统计学意义（P＜0.05），治疗6个月后两组患者的红细胞压积、纤维蛋白原、血浆比粘度均较治疗前降低，具有统计学差异（P＜0.05），但两组间比较差异无统计学意义（P＞0.05）,两组治疗前后实验室指标未见明显异常，未见严重不良反应。结论：脑血疏口服液能够改善患者日常生活能力和认知能力，对血管性认知功能障碍的远期效果明显优于尼莫地平组。
Abstract:
Abstract Objecive：To observe the clinical therapeutic effects of the Naoxueshu oral liquid in the treatment of patients with vascular cognitive impairment(VCI) and the influence on cognitive function．Methods：80 cases with VCI were randomly divided into treatment group and control group,with 40 cases in each group. Patients in the treatment group were given Naoxueshu oral liquid,10 ml at a time,three times per day,while others in the control group were treated with nimodipine,30 mg a time,three times per day. Both groups received six-month treatment. Cognitive ability,activity of daily living before and after treatment were evaluated and dynamical parameters of cerebral circulation were detected. The incidence of adverse reactions was statistically analyzed．Results：After 1,3,6 months of treatment，scores of Mini-mental state examination ( MMSE)，Activity of daily living( ADL) were significantly higher than that of before the treatment in the two groups. The difference was statistically significant（P＜0.05）. After treatment of 1 months,there was no significant difference between the two groups（P＞0.05）. After 3,6 months of treatment，with obvious increases in the scores of MMSE and ADL when compared to the control group,the difference was statistically significant（P＜0.05）.Hematocrit，fibrinogen and plasma specific viscosity were significantly lower in the two groups than before treatment,the difference was statistically significant（P＜0.05）,but there was no significant difference between the two groups（P＞0.05）.Neither evident abnormalities nor side effects were detected before and after treatment in the test. Conclusion：Naoxueshu oral liquid can efficiently improve the daily living activity and cognitive function,the long-term effect of Naoxueshu oral liquid on patients with VCI was significantly better than that of nimodipine group.

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备注/Memo

备注/Memo:
*陕西省社会发展科技攻关项目（2016SF169，2015SF209）
更新日期/Last Update: 2019-08-15