[1]余 华,陈 钧,吴甲锋,等.失眠颗粒对昼夜节律紊乱性睡眠障碍的调节作用研究*[J].陕西中医,2019,(8):1081-1084.
　YU Hua,CHEN Jun,ZHOU Hui,et al.Regulatory effect of insomnia granule on circadian rhythm disorder sleep disorder[J].,2019,(8):1081-1084.
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失眠颗粒对昼夜节律紊乱性睡眠障碍的调节作用研究*

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1081-1084
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Regulatory effect of insomnia granule on circadian rhythm disorder sleep disorder
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.08.026
作者:
余 华1;  陈 钧1; 吴甲锋2; 周 辉3; 董 静4△
1.陕西省中医医院（西安 710003）；2.陕西省商洛市柞水县中医医院（商洛 711400）；3.陕西省汉中市西乡县人民医院（汉中 723500）；4. 西安市第五医院（西安 710082）
Author(s):
YU Hua; CHEN Jun; ZHOU Hui; et al.
Shaanxi Provincial Hospital of Traditional Chinese Medicine(Xi’an 710000)
关键词:
昼夜节律紊乱; 睡眠障碍; 医护人员; 失眠颗粒; 认知行为治疗; 调节作用
Keywords:
Key words Circadian rhythm disorder; Sleep disorders; Medical staff; Insomnia granules; Cognitive behavioral therapy; Regulatory effects
分类号:
R749.72
文献标志码:
A
摘要:
摘 要 目的： 探讨失眠颗粒对昼夜节律紊乱性睡眠障碍的调节作用。方法： 选取符合西医昼夜节律失调性睡眠障碍诊断的医护人员60名，随机分为对照组和治疗组各30例。对照组和治疗组在给予简单的认知行为疗法及睡眠指导常规治疗,在此基础上对照组口服安慰剂，治疗组口服失眠颗粒。观察两组治疗前后ESS(爱泼沃思睡量表) 、ISI（失眠严重指数量表）、PSQI评分（匹兹堡睡眠质量指数）及中医症状评分等指标。结果： 治疗组总有效率为93.33％高于对照组的83.33％，两组间治疗后差异有统计学意义(P＜0.05)。两组患者ESS评分 、ISI评分、PSQI评分均显著降低(P＜0.05)，且治疗组低于对照组(P＜0.05)。治疗后，两组患者的中医症状评分降低（P＜0.05）；治疗后治疗组症状评分大多低于对照组（P＜0.05）。结论 ：对于昼夜节律紊乱性睡眠障碍患者治疗疗效显著，具有疏肝清热、养心安神的功效，治疗过程中不良反应少，安全性能高。
Abstract:
Abstract Objective: To Investigate the regulatory effect of insomnia granule on circadian rhythm disorder. Methods: 60 medical workers who were diagnosed with circadian dysrhythmia sleep disorder were stochastic divided into control group and treatment group，30 cases each.The control group and the treatment group were given simple cognitive behavioral therapy and routine sleep guidance therapy，on this basis，the control group was given oral placebo，and the treatment group was given oral insomnia granules.ESS(epworth sleep scale)，ISI (severe insomnia index scale)，PSQI score (Pittsburgh sleep quality index) and TCM symptom score were looked into before treatment and after treatment. Results :The total effective rate of the treatment group was 93.33%，which was significantly higher than that of the control group (83.33%)，with statistical difference between the two groups (P＜0.05).After treatment，ESS score，ISI score and PSQI score in both groups were significantly reduced (P＜0.05)，and the treatment group was lower than the control group(P＜0.05).After treatment，the TCM symptom scores of the two groups were decreased (P＜0.05).After treatment，the symptom scores of the treatment group were mostly lower than those of the control group(P＜0.05). Conclusion:It has significant therapeutic effect on patients with circadian rhythm disorder sleep disorder，and has the effect of soothing the liver，clearing heat，nourishing the heart and calming the mind. In the process of treatment，there are few adverse reactions and high safety performance，so it has clinical application value.

参考文献/References:

[1] 洪肖娟.昼夜节律紊乱性睡眠障碍的中西医研究进展\[C\].2014年.中国针灸学会循证针灸专业委员会:脑病专业委员会学术大会论文集,2014:111.
[2] Papantoniouk，Devoreee，Massaj，et al.Rotating night shift work and colorectal cancer risk in the nurses′ health studies[J].Int J Cancer,2018,143(11):2709-2717. 
[3] Yuan X，Zhu C，Wang M，et al.Night shift work increases the risks of multiple primary cancers in women:a systematic review and meta-analysis of 61articles[J].Cancer Epidemiol Biomarkers Prev,2018,27(1):25-40. 
[4] 王 晔,杨海霞,郭 蓉，等.补阴泻阳法对阴虚火旺型老年失眠患者睡眠质量的影响[J].陕西中医，2017,38(9)：1241-1242.
[5] 吕中卿,熊桂华.中西医结合治疗昼夜节律紊乱性睡眠障碍的研究进展[J].中国医药指南,2017,15(34):14-15.
[6] 张 斌.中国失眠障碍诊断和治疗指南［M］. 北京: 人民卫生出版社，2016: 1-131.
[7] 中医中医科学院失眠症中医临床实践指南课题组. 失眠症中医临床实践指南(WHO/WPO)[J]. 世界睡眠医学杂志，2016，3(1): 8-25.
[8] 丁庆华,梁学军,甘景梨.失眠症患者认知行为疗法的研究进展[J].中国疗养医学,2018,27(11):1146-1148.
[9] 中国睡眠研究会. 中国失眠症诊断和治疗指南[J]. 中华医学杂志，2017，97(24): 1844-1856. 
[10] Damiani MF，Quaranta VN，Falcone VA,et al. The Epworth sleepiness scale: conventional self vs physician administration[J]. Chest，2013，143(6): 1569-1575. 
[11] Morin CM，Belleville G，Belanger L，et al. The insomnia severity index: psychometric indicators to detect insomnia cases and evaluate treatment response[J]. Sleep，2011，34(5): 601-608.
[12] 谭元坤.中医量表跨文化调适研究的推荐报道清单的研制[D].广州中医药大学,2016.
[13] 杨 辉,唐 珊,王巧红，等.护士职业人群昼夜节律紊乱不良结局的研究进展[J].护理研究,2019,33(5) :816-821.
[14] 吴鹏亮,韩祖成.韩祖成教授治疗失眠之经验[J].陕西中医,2015,36(5):594-595.
[15] 左常波,郭丹丹.气机升降针法治疗肝郁型失眠的临床观察[J].广州中医药大学学报,2015,32(4):690-693.

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备注/Memo

备注/Memo:
*陕西省中医药管理局资助课题（15-LC019）
更新日期/Last Update: 2019-08-15