[1]李 欣,张 巍,申东东,等.止咳平喘方治疗婴幼儿哮喘疗效及对患儿外周血树突细胞共刺激分子的影响*[J].陕西中医,2019,(9):1170-1173.
　LI Xin,ZHANG Wei,SHEN Dongdong,et al.Effects of Zhike Pingchuan recipe on the efficacy of infant asthma and the costimulatory molecules of peripheral blood dendritic cells[J].,2019,(9):1170-1173.
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止咳平喘方治疗婴幼儿哮喘疗效及对患儿外周血树突细胞共刺激分子的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1170-1173
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
Effects of Zhike Pingchuan recipe on the efficacy of infant asthma and the costimulatory molecules of peripheral blood dendritic cells
文章编号:
DOI:10.3969/j.issn.10007369.2019.09.005
作者:
李 欣1; 张 巍1; 申东东2; 任玉梅3
1.河南中医药大学第三附属医院（郑州450000）；2.河南省中医院儿科（郑州450000）3.河南中医药大学第二附属医院儿科（郑州450000）
Author(s):
LI Xin; ZHANG Wei; SHEN Dongdong; et al.
Third Affiliated Hospital of Henan University of Traditional Chinese Medicine（Zhengzhou 450000）
关键词:
止咳平喘方; 婴幼儿哮喘; 疗效研究; 外周血; 树突状细胞; 刺激分子
Keywords:
Key words Zhike Pingchuan recipe; Infant asthma; Curative effect; Peripheral blood; Dendritic cells; Stimulate the molecular
分类号:
R256.12
文献标志码:
A
摘要:
摘 要 目的：探讨止咳平喘方对婴幼儿哮喘疗效及外周血树突细胞(DC)共刺激分子的影响。方法：收治的118例哮喘婴幼儿患者，用随机数字表法分为两组，对照组予常规西医治疗，观察组在对照组基础上加用中药止咳平喘方。系统观察：两组临床疗效、外周血DC表面分子水平、血清Th1及Th2水平。结果：观察组总有效率94.6%显著高于对照组总有效率83.1%（P＜0.05）。观察组中医症候积分治疗前后差值(10.79±3.54)分显著高于对照组(5.86±2.42)分(P＜0.05)。治疗后，两组CD80、CD86、HLADR指标显著低于治疗前(P＜0.05)，两组CD40指标显著高于治疗前(P＜0.05)。治疗后，观察组Th1细胞(32.59±7.54)%，对照组(26.38±6.86)%显著高于治疗前(18.64±4.32)%和对照组(18.52±5.34)%，(P＜0.05)。Th2细胞(25.95±8.69)%，(31.65±10.47)%显著低于治疗前 (37.29±14.52)%和对照组(31.65±10.47)%，(P＜0.05)；Th1/Th2(1.15±0.36)%，(0.83±0.14)%显著高于治疗前(0.71±0.18)%和对照组(0.83±0.14)%，(P＜0.05)。两组免疫功能各指标均显著高于治疗前(P＜0.05) ，且观察组显著高于对照组(P＜0.05)。结论：止咳平喘方治疗婴幼儿哮喘疗效显著，可有效降低DC细胞表面分子表达，协调辅助T淋巴细胞Th1/Th2失衡。
Abstract:
Abstract Objective：To investigate the effect of Zhike Pingchuan recipe on asthma in infants and their peripheral blood dendritic cells (DC) costimulatory molecules.Methods：118 cases of infant asthma patients admitted were selected and divided into two groups by random number table method.The control group was treated with conventional western medicine,and the observation group was treated with traditional Chinese medicine cough and asthma relieving prescription on the basis of the control group.Systematic observation clinical efficacy,surface molecule level of DC in peripheral blood,serum Th1 and Th2 levels in the two groups.Results:The total effective rate of the observation group was 94.6%,which was significantly higher than the total effective rate of the control group 83.1% (P＜0.05).The difference between the observation group and the TCM symptom score before and after treatment (10.79±3.54) was significantly higher than that before the control (5.86±2.42)points(P＜0.05).After treatment,the CD80,CD86,and HLADR indexes of the two groups were significantly lower than those before treatment (P＜0.05).The CD40 indexes of the two groups were significantly higher than those before treatment (P＜0.05).After treatment,the Th1 cells in the observation group (32.59±7.54)%,the control group (26.38±6.86)% were significantly higher than the pretreatment (18.64±4.32)% and the control group (18.52±5.34)%,(P＜0.05).Th2 Cells (25.95±8.69)%,(31.65±10.47)% were significantly lower than that before treatment (37.29±14.52)% and control group (31.65±10.47)%,(P＜0.05).Th1/Th2(1.15±0.36)% (0.83±0.14)% was significantly higher than before treatment (0.71±0.18)% and the control group (0.83±0.14)%,(P＜0.05).Indexes of immune function were significantly higher than those before treatment (P＜0.05).The observation group was significantly〖LM〗 higher than the control group (P＜0.05).Conclusion:Traditional Chinese medicine cough and asthma prescription has significant effect on the treatment of infant asthma,which can effectively reduce the expression of molecules on the surface of DC cells,coordinate the imbalance of Th1/Th2 in helper T lymphocytes,and is worthy of clinical promotion and application.

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备注/Memo

备注/Memo:
*河南省科学技术厅基金资助项目（152102310010）
更新日期/Last Update: 2019-09-24