[1]王爱丽,李瑞婷 ,张月萍△.苍术方治疗儿童功能性便秘疗效研究[J].陕西中医,2019,(9):1199-1201.
 WANG Aili,LI Ruiting,ZHANG Yueping..Efficacy analysis of Cangzhu prescription in treatment of functional constipation in children[J].,2019,(9):1199-1201.
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苍术方治疗儿童功能性便秘疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1199-1201
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
Efficacy analysis of Cangzhu prescription in treatment of functional constipation in children
文章编号:
DOI:10.3969/j.issn.10007369.2019.09.013
作者:
王爱丽1李瑞婷12 张月萍1△
1.空军军医大学西京医院儿科(西安710032);2.西安交通大学第一附属医院(西安710061)
Author(s):
WANG AiliLI RuitingZHANG Yueping.
Department of Pediatrics,Xijing Hospital of Air Force Military Medical University(Xi’an 710032)
关键词:
功能性便秘苍术方乳果糖便秘症状积分疗效儿童
Keywords:
Key words Functional constipationCangzhu prescriptionLactuloseSymptoms and scores of constipationTherapeutic effectChild
分类号:
R256.35
文献标志码:
A
摘要:
摘 要 目的:研究苍术方治疗儿童功能性便秘(FC)的有效性和安全性。方法:选择FC患儿共82例,分为苍术方组(44例)与乳果糖组(38例),分别给予苍术方免煎颗粒及乳果糖口服液治疗2周,比较两组患儿治疗前后便秘症状积分和疗效,观察不良反应发生情况。结果:两组患儿治疗1周和2周时便秘症状积分均明显下降,与治疗前比较差异具有统计学意义(P<0.01)。停药2周时,苍术方组便秘症状积分仍保持较低水平,而乳果糖组积分显著回升(P<0.01),苍术方组显效率高于乳果糖组(P<0.01),观察期间两组均无不良反应发生。结论:苍术方治疗儿童FC疗效较好,短期内无复发,无不良反应。
Abstract:
Abstract Objective:To study the efficacy and safety of Cangzhu prescription for the treatment of functional constipation in children.Methods:82 children with functional constipation were choosen as study objects.They were divided into Cangzhu prescription group (44 cases) and lactulose group (38 cases).The patients were treated with Cangzhu prescription free fried granules or lactulose solution for 2 weeks.The symptoms and scores of constipation before and after treatment,as well as the therapeutic effect were compared between the two groups,the adverse reactions were observed.Results:In both groups,the scores of constipation symptoms were decreased significantly after 1 week and 2 weeks of treatment,compared with the baseline scores,the difference was statistically significant (P<0.01).At 2 weeks of drug withdrawal,the scores of Cangzhu prescription remained low,while the scores of lactulose group increased significantly (P<0.01).The effective rate in Cangzhu prescription group was higher than that of lactulose group (P<0.01).No adverse events occurred during the treatment in either group.Conclusion:Cangzhu prescription is effective in children with functional constipation and no recurrence after withdrawal in shortterm,no adverse reactions.

参考文献/References:

[1] Vanden Berg MM,Benninga MA,Di Lorenzo C.Epidemiology of childhood constipation:a systematic review[J] .Am J Gastroenterol,2006,101(10):24012409.
[2] 杨春松,张伶俐,任 燕,等.国内儿童功能性便秘患病率和纤维素治疗有效性的文献评价[J] .中国药事,2017,31(5):579583.
[3] Bongers ME,Wijk MP,Reitsma JB,et al.Longterm prognosis for childhood constipation:clinical outcomes in adulthood[J] .Pediatrics,2010,126(1):e156e162.
[4] 翁剑锋,邱啸臣,李元新.功能性便秘的治疗进展[J] .中国临床研究,2016,29(3):409412.
[5] 方万红.四磨汤辅助治疗对儿童便秘对肠道菌群和消化功能影响[J] .陕西中医,2019,40(3):364367.
[6] 蔡翊鸿,吴晔明.中西医治疗儿童便秘研究进展[J] .现代中西医结合杂志,2017,26(26):29612964.
[7] Hyams JS,Di Lorenzo C,Saps M,et al.Childhood functional gastrointestinal disorders:Child/adolescent[J] .Gastroenterology,2016,150(6):14561468.
[8] 王宝西,王茂贵,杨 敏,等.小儿功能性便秘临床特征与分型[J] .临床儿科杂志,2003,21(12):762764.
[9] 中华医学会外科学分会肛肠外科学组.便秘症状及疗效评估[J] .中华胃肠外科杂志,2005,8(4):355.
[10] 非比麸临床协作组.小麦纤维素颗粒治疗功能性便秘的多中心临床试验[J] .中华消化杂志,2009,29(4):271272.
[11] Tabbers MM,Dilorenzo C,Berger MY,et al.Evaluation and treatment of functional constipation in infants and children:evidencebased recommendations from Espghan and Naspghan[J] .J Pediatr Gastroenterol Nutr,2014,58(2):258274.
[12] 王宝西,郭宏伟.益生菌在儿童功能性便秘的应用[J] .中国实用儿科杂志,2017,32(2):103106.
[13] Kimura Y,Sumiyoshi M.Effects of an atractylodes lancea rhizome extract and a volatile component betaeudesmol on gastrointestinal motility in mice [J] .J Ethnopharmacol,2012,41(1):530536.
[14] 张明发,沈雅琴.苍术及其活性成分β桉叶醇的神经药理作用的研究进展[J] .抗感染药学,2017,1(14):6.
[15] 尹占芳,董小强.决明子的化学成分及药理作用研究[J] .中国当代医药,2013,20(7):1819.
[16] 孔 霞,蔡 瑾,陈 燕.白芍总苷的药理作用研究进展[J] .中医中药,2016,24(3):188190.

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更新日期/Last Update: 2019-09-24