[1]邹武军,郭焕利△,李晓丽,等.麻甘颗粒联合阿奇霉素治疗小儿支原体肺炎疗效研究*[J].陕西中医,2019,(11):1582-1585，1589.
　ZOU Wujun,GUO Huanli,LI Xiaoli,et al.Curative effect and mechanism of Magan granules combined with azithromycin in treatment of children with mycoplasma pneumoniae pneumonia[J].,2019,(11):1582-1585，1589.
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麻甘颗粒联合阿奇霉素治疗小儿支原体肺炎疗效研究*

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年11期
页码:
1582-1585，1589
栏目:
临床研究
出版日期:
2019-11-05

文章信息/Info

Title:
Curative effect and mechanism of Magan granules combined with azithromycin in treatment of children with mycoplasma pneumoniae pneumonia
文章编号:
DOI:10.3969/j.issn.10007369.2019.11.026
作者:
邹武军; 郭焕利△; 李晓丽; 胡明贤
陕西省安康市中心医院儿科（安康 725000）
Author(s):
ZOU Wujun; GUO Huanli; LI Xiaoli; et al.
Department of Pediatrics,Ankang Central Hospital (Ankang 725000)
关键词:
麻甘颗粒; 阿奇霉素; 小儿支原体肺炎; 疗效; 炎症因子; 免疫功能
Keywords:
Key words Magan granules; Azithromycin; Children with mycoplasma pneumoniae pneumonia; Curative effect; Inflammatory factor; Immune function
分类号:
R725.6
文献标志码:
A
摘要:
摘要目的：探讨麻甘颗粒联合阿奇霉素治疗小儿支原体肺炎（MPP）的疗效及机制。方法：选取MPP 102例为研究对象，采用信封法随机分为观察组和对照组各51例，对照组给予阿奇霉素治疗，观察组在此基础上联合麻甘颗粒进行治疗，探讨对患者临床症状、炎症因子及免疫功能的影响。结果：观察组治疗有效率96.08%显著高于对照组80.39%（P＜005）；治疗后两组咳嗽气喘、痰黄而多、发热、咽红肿、舌红苔黄症状积分均显著降低，且观察组治疗后以上积分均明显低于对照组（P＜005）；治疗后两组肿瘤坏死因子（TNFα）、白介素6（IL6）、干扰素γ（IFNγ）、白介素10（IL10）、白介素4（IL4）水平均显著降低，白介素2（IL2）水平均显著升高，且观察组治疗后TNFα、IL6、IFNγ、IL10、IL4水平均明显低于对照组，IL2水平明显高于对照组（P＜005）；治疗后两组红细胞免疫复合物（RBCICR）、CD8+占比情况均显著降低，红细胞C3b受体（PBCC3bR）、CD3+、CD4+占比情况均显著升高，且观察组治疗后RBCICR、CD8+占比情况均明显低于对照组，PBCC3bR、CD3+、CD4+占比情况明显高于对照组（P＜005）；观察组不良反应发生率7.84%显著低于对照组25.49%（P＜005）。结论：麻甘颗粒联合阿奇霉素治疗MPP疗效确切，可显著改善患者临床症状，另外患者的炎症因子、免疫功能均有所改变，推测麻甘颗粒联合阿奇霉素治疗MPP的机制可能与降低机体促炎因子水平，升高抗炎因子水平，改善机体免疫功能相关，且不良反应显著降低。
Abstract:
AbstractObjective:To investigate the curative effect and mechanism of Magan granules combined with azithromycin in the treatment of children with mycoplasma pneumoniae pneumonia (MPP).Methods:102 children with MPP were selected as subjects.They were randomly divided into observation group and control group by envekop method,51 cases in each group.The control group was treated with azithromycin while the observation group was treated with azithromycin combined with Magan granules.The curative effect was analyzed,and the effects on clinical symptoms,inflammatory factors and immune function were explored.Results:The response rate of the observation group was significantly higher than that of the control group (96.08% vs 80.39%,P＜005).After treatment,scores of cough asthma,much yellow phlegm,fever,and red and swollen throat of both groups were significantly decreased.The scores of the observation group were significantly lower than those of the control group (P＜005).After treatment,levels of tumor necrosis factor (TNFα),interleukin6 (IL6),interferonγ (IFNγ),interleukin10 (IL10) and interleukin4 (IL4) were significantly decreased,interleukin2 (IL2) levels were significantly increased.Levels of TNFα,IL6,IFNγ,IL10 and IL4 in the observation group after treatment were significantly lower than those in the control group,while the IL2 level was significantly higher than the control group (P＜005).After treatment,ratios of red blood cell immune complex rosette (RBCICR) and CD8+ in both groups were significantly reduced,while ratios of red blood cell C3b receptor (PBCC3bR),CD3+ and CD4+ were significantly increased.Ratios of RBCICR and CD8+ in the observation group after treatment were significantly lower than those in the control group,while ratios of PBCC3bR,CD3+ and CD4+ were significantly higher than those in the control group〖LM〗 (P＜005).The incidence of adverse reactions in the observation group was significantly lower than that in the control group (7.84% vs 25.49%,P＜005).Conclusion:Magan granules combined with azithromycin is effective in the treatment of MPP.The combined treatment can significantly improve the clinical symptoms of patients.In addition,the inflammatory factors and immune function of patients are changed.It is speculated that the mechanism of Magan granules combined with azithromycin in the treatment of MPP may be related to reducing levels of proinflammatory factors,increasing levels of antiinflammatory factors,and improving the body's immune function. 

参考文献/References:

[1]陈咏丽,严晓娟.小儿肺炎支原体感染肺外消化系统损害及其相关因素分析[J].重庆医学,2014,43(7):863866.
[2]谢辉.阿奇霉素联合脂溶性维生素治疗小儿肺炎支原体肺炎的临床观察[J].重庆医学,2016,45(8):11511152.
[3]郑锋,陆凤娟,徐 颖,等.双黄连颗粒联合阿奇霉素干混悬剂治疗小儿支原体肺炎的临床疗效观察[J].中药材,2015,38(2):416418.
[4]林坚,许志有,邢东文,等.痰热清注射液联合阿奇霉素治疗小儿支原体肺炎的疗效及对炎症因子的影响[J].中华中医药学刊,2017,35(9):24182420.
[5]王月红,张娅杰,谷强,等.肺炎支原体感染的哮喘患儿血清CD40L、VCAM1水平变化及其意义[J].山东医药,2017,57(46):7880.
[6]邵新环,张彩艳,吕俊,等.小儿肺炎支原体肺炎的临床特点(附226例分析)[J].山东医药,2017,57(31):7375.
[7]张益谋.炎琥宁对小儿支原体肺炎患者抗炎、促炎因子及免疫功能的影响[J].实用医学杂志,2013,29(16):26082610.
[8]罗钦宏,梁锦枝,黄艳琼,等.炎琥宁联合阿奇霉素治疗小儿支原体肺炎的疗效及安全性的Meta分析[J].中国实验方剂学杂志,2014,20(1):198203.
[9]赵小花,沈国武,徐长艳,等.阿奇霉素对小儿支原体肺炎患者C反应蛋白与心肌酶含量影响及临床疗效[J].中国医院药学杂志,2014,34(7):562564.
[10]李丽丽,刘薇薇,陈慧,等.中西医结合治疗小儿肺炎支原体肺炎优势及远期疗效分析[J].辽宁中医杂志,2013,40(10):20822084.
[11]荣毅,王蕾,刘志国,等.益气养阴、清热活血法治疗小儿重症肺炎支原体肺炎合并肺不张[J].中医杂志,2018,59(16):8183.
[12]车颖悟,佟晓辉,黄晓娟,等.自拟中药方联合阿奇霉素治疗小儿支原体肺炎的疗效观察[J].中国药房,2013,15(20):18751876.
[13]马春兰,范亚莉,刘润武,等.小儿麻甘颗粒对小儿肺炎的治疗效果及对炎症细胞因子水平的影响[J].中药材,2018,41(1):222224.
[14]赵思佳,马艳红,傅延龄,等.麻杏石甘汤治疗小儿肺炎随机对照试验的系统评价及量效分析研究[J].中华中医药杂志,2013,28(2):361367.
[15]韩晓虹,陆晓丹,符青,等.小儿消积止咳口服液联合阿奇霉素治疗小儿支原体肺炎[J].辽宁中医杂志,2018,490(3):551553.
[16]李茜梅,汤昱,徐沙沙,等.麻杏石甘汤联合纤支镜治疗儿童支原体肺炎的疗效及对免疫球蛋白、凝血酶调节蛋白水平的影响[J].中华中医药学刊,2019,37(1):233236.
[17]边红恩,陈团营,单海军,等.麻杏石甘汤联合阿奇霉素对小儿支原体肺炎患者抗炎、促炎因子及免疫功能的影响[J].中国实验方剂学杂志,2017,23(22):177181.

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备注/Memo

备注/Memo:
*陕西省科学技术研究发展计划项目 (S2017HYGF0108621)
更新日期/Last Update: 2019-11-15