[1]胡汉楚,张 征,王赤华.芪独合剂改善缺血性脑卒中恢复期患者神经缺损程度、〖JZ〗颈动脉粥样硬化、血管内皮生长因子临床研究*[J].陕西中医,2020,(1):24-28.
　HU Hanchu,ZHANG Zheng,WANG Chihua..Clinical study on improving the degree of nerve defect,carotid atherosclerosis and vascular endothelial 〖JZ〗growth factor in patients with ischemic stroke during recovery period by Qidu mixture decoction[J].,2020,(1):24-28.
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芪独合剂改善缺血性脑卒中恢复期患者神经缺损程度、〖JZ〗颈动脉粥样硬化、血管内皮生长因子临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年1期
页码:
24-28
栏目:
临床研究
出版日期:
2020-01-05

文章信息/Info

Title:
Clinical study on improving the degree of nerve defect,carotid atherosclerosis and vascular endothelial 〖JZ〗growth factor in patients with ischemic stroke during recovery period by Qidu mixture decoction
文章编号:
DOI:10.3969/j.issn.10007369.2020.01.006
作者:
胡汉楚1; 张 征2; 王赤华3
1.湖北省黄冈市中医医院内科（黄冈 438000）；2.湖北省黄冈市中医医院骨科（黄冈 438000）；〖JZ〗3.湖北省黄冈市疾病预防控制中心检验科（黄冈 438000）
Author(s):
HU Hanchu; ZHANG Zheng; WANG Chihua.
Department of Internal Medicine,〖JZ〗Huanggang Hospital of Traditional Chinese Medicine in Hubei Province（Huanggang 438000）
关键词:
缺血性中风病恢复期; 芪独合剂; 神经缺损程度; 颈动脉粥样硬化; 血管内皮生长因子; 临床研究
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗Convalescence of ischemic stroke; Selfdesigned Qidu mixture decoction; Nerve defect degree; Carotid atherosclerosis; Vascular endothelial growth factor; Clinical research
分类号:
R743.3
文献标志码:
A
摘要:
摘 要 目的：探讨芪独合剂改善缺血性脑卒中恢复期（气虚血瘀、络脉痹阻证）患者的临床效果，探讨其对患者神经缺损程度、颈动脉粥样硬化、血管内皮生长因子的影响。方法：将110例缺血性脑卒中恢复期患者采用随机数字表法分为对照组和观察组，每组55例。对照组患者给予常规西药治疗，观察组患者在对照组基础上加用芪独合剂口服，1个月为1个疗程，连续用药2个疗程。观察两组治疗的临床效果，评价神经功能缺损程度、运动功能、日常生活能力变化，检测颈动脉内膜中层厚度(IMT)、斑块面积、大脑中动脉血流速度，监测血管内皮生长因子（VEGF)水平变化。结果：观察组、对照组的有效率分别为90.91%（50/55）、76.36%（42/55），以观察组有效率明显升高（P＜0.05）；观察组患者治疗后的神经功能缺损程度较对照组明显减轻，治疗1个月、治疗2个月的NIHSS评分显著低于治疗前及对照组（P＜0.05）；观察组患者治疗后的运动功能、日常生活能力改善优于对照组，FMA评分、Barthel指数评分均显著高于对照组（P＜0.05）；观察组患者治疗后的颈动脉粥样硬化改善优于对照组，斑块IMT厚度、斑块面积均显著小于对照组（P＜0.05）；观察组患者治疗后的脑血流改善优于对照组，Vm、Vd、Vs均显著高于对照组（P＜0.05）；观察组患者治疗1个月、治疗2个月的VEGF水平显著高于治疗前及对照组（P＜0.05）。结论：芪独合剂能有效提高运动功能、日常生活能力，改善颈动脉粥样硬化程度，增加脑血流量，促进新生血管形成，从而促进受损神经功能的修复。
Abstract:
Abstract 〖WT5BZ〗〖HT5”SS〗Objective:To investigate the clinical effect of selfdesigned Qidu mixture decoction in improving the recovery period of ischemic stroke (qi deficiency and blood stasis syndrome,collateralisedartery obstruction syndrome),and explore the effect on the degree of nerve defect,carotid atherosclerosis and vascular endothelial growth factor in patients.Methods:110 cases of ischemic stroke convalescent patients were divided into control group and observation group by random number table method,with 55 cases in each group.Patients in the control group were given conventional western medicine treatment,and patients in the observation group were given oral administration of selfdesigned Qidu mixture decoction on the basis of the control group,with 1 course of treatment for 1 month and 2 courses of continuous medication.Clinical effects of the two groups were observed,the changes of nerve dysfunction,motor function and daily living ability were evaluated,IMT,plaque area and blood flow velocity of middle cerebral artery were tested,and the changes in VEGF levels were monitored.Results:The effective rate of observation group and control group were 90.91% (50/55) and 76.36% (42/55) respectively,which significantly increased the effective rate of observation group (P＜0.05).The degree of neurological impairment in the observation group was significantly reduced compared 〖JP2〗with that in the control group,and the NIHSS scores at 1 month and 2 months after treatment 〖JP〗〖LM〗were significantly lower than those before treatment and in the control group (P＜0.05).The improvement of motor function and daily living ability of the observation group was better than that of the control group,and the FMA score and Barthel index score were significantly higher than those of the control group (P＜0.05).The improvement of carotid atherosclerosis after treatment in the observation group was better than that in the control group,and the IMT thickness and plaque area of the plaque were significantly smaller than those in the control group (P＜0.05).The improvement of cerebral blood flow in the observation group was better than that in the control group,and Vm,Vd and Vs were significantly higher than those in the control group (P＜0.05).The VEGF levels in the observation group at 1 month and 2 months of treatment were significantly higher than those in the control group and before treatment (P＜0.05).Conclusion:Qidu mixture decoction can effectively improve motor function,daily living ability,improve the degree of carotid atherosclerosis,increase cerebral blood flow,promote the formation of new blood vessels,and thus promote the repair of damaged nerve function.

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备注/Memo

备注/Memo:
*湖北省科学技术厅课题（EK2013D210063001645、EK2014D210006000852）
更新日期/Last Update: 2020-02-17