[1]陈 军,乔海法,李 静,等.艾灸背俞穴联合羟考酮缓释片干预癌痛临床研究*[J].陕西中医,2020,(1):105-107.
　CHEN Jun,QIAO Haifa,LI Jing,et al.The clinic research of BackShu point moxibustion plus oral oxycodone in cancer pain[J].,2020,(1):105-107.
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艾灸背俞穴联合羟考酮缓释片干预癌痛临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年1期
页码:
105-107
栏目:
针灸经络
出版日期:
2020-01-05

文章信息/Info

Title:
The clinic research of BackShu point moxibustion plus oral oxycodone in cancer pain
文章编号:
DOI:10.3969/j.issn.10007369.2020.01.030
作者:
陈 军1; 乔海法1; 李 静2; 刘 奇1; Karataye Va Kymba1(哈萨克斯坦)
1.陕西中医药大学针灸推拿学院 （咸阳712046）；2.解放军总医院第六医学中心中医科（北京100048）
Author(s):
CHEN Jun; QIAO Haifa; LI Jing; et al.
Department of Acupuncture and Massage,Shaanxi University of Chinese Medicine (Xianyang 712046) 
关键词:
艾灸; 羟考酮; 癌痛; 背俞穴; 白介素6; 肿瘤坏死因子α
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗Moxibustion; Oxycodone; Cancer pain; BackShu point; IL6; TNFα
分类号:
R730.6
文献标志码:
A
摘要:
摘 要 目的：观察艾灸背俞穴联合盐酸羟考酮缓释片对癌痛患者的镇痛作用。方法：采取随机对照的临床研究模型，纳入病例随机分成两组，对照组给予口服盐酸羟考酮缓释片治疗，观察组在对照组基础上给予艾灸背俞穴，两组疗程均为6 d。采用数字化评估表法（NRS）进行疼痛定量评估，以疼痛缓解率（PAR）评估疼痛改善效率，并于第7天采血清样本，检测IL6及TNFα水平。结果：两组治疗后各时段NRS评分均较治疗前显著下降（P均＜0.05），观察组治疗后NRS评分均优于对照组（P均＜0.05）；两组治疗后观察组PAR优于对照组（P＜0.05）；两组治疗后血清TNFα水平均较治疗前显著降低（P＜0.05）且观察组优于对照组（P＜0.05）；对照组治疗后血清IL6水平无明显改变（P＞0.05），观察组治疗后血清IL6水平较治疗前显著降低（P＜0.05）。结论：艾灸背俞穴可对盐酸羟考酮缓释片的止痛效果有显著协同作用，初步证实该作用与炎症反应因子IL6及TNFα降低有关。
Abstract:
Abstract 〖WT5BZ〗〖HT5”SS〗Objection:To compare therapeutic effects of analgesia induced by BackShu point moxibustion plus oral oxycodone tablets.Methods:Randomized controlled trial (RCT) research was designed in this study.The observation groups were treated with BackShu point moxibustion plus oxycodone,and the controls with oxycodone only.Course of the treatment was 6 days.Pain intensity was assessed by numerical rating scale (NRS);and pain relief rate (PAR) was used to assessing analgesia improvement efficiency.On 7th day,serum IL6 and TNFα were detected by ELISA.Result:This study showed that NRS scores in both groups were decreased (all P<0.05).,and the NRS scores in the observation groups were better than that in the control groups (all P<0.05).And PAR of the observation group was better than that of the control group after treatment (P＜0.05).Serum TNFα which after treatment was significantly lower than that before treatment in both groups (P＜0.05),and it was more significantly in observation groups (P＜0.05).There was no significant changed in serum IL6 level in the control groups (P＞0.05);while the serum IL6 was obviously diminished in the observation groups (P＜0.05).Conclusion:Moxibustion at BackShu point had a significant synergistic ability on the analgesic effect of oral oxycodone tablets.This effect has been preliminarily confirmed to be related to the reduction of inflammatory response factors IL6 and TNFα.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目（81704186）
更新日期/Last Update: 2020-02-17