[1]史小琴,钱 瑶△.连续性肾脏替代治疗联合中药灌肠对急性肾损伤患者尿KIM-1、NGAL水平的影响*[J].陕西中医,2020,(2):210-212，216.
　SHI Xiaoqin,QIAN Yao..Effect of CRRT combined with clyster with Chinese herbs on urinary KIM-1,NGAL level and prognosis in patients with severe acute renal injury[J].,2020,(2):210-212，216.
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连续性肾脏替代治疗联合中药灌肠对急性肾损伤患者尿KIM-1、NGAL水平的影响*

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年2期
页码:
210-212，216
栏目:
临床研究
出版日期:
2020-02-05

文章信息/Info

Title:
Effect of CRRT combined with clyster with Chinese herbs on urinary KIM-1,NGAL level and prognosis in patients with severe acute renal injury
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007369.2020.02.019
作者:
史小琴; 钱 瑶△
华中科技大学同济医学院附属梨园医院肾内科血液净化室(武汉 430000)
Author(s):
SHI Xiaoqin; QIAN Yao.
Blood Purification Room,Kidney Department,Liyuan Hospital,Tongji Medical College,Huazhong University of Science And Technology(Wuhan 430000)
关键词:
重症急性肾损伤;  连续性肾脏替代治疗;  中药灌肠;  肾损伤分子-1;  中性粒细胞明胶酶相关脂质运载蛋白;  预后
Keywords:
Severe acute renal injury;  Continuous renal replacement therapy;  Traditional Chinese medicine enema;  Renal injury molecule-1;  Neutrophil gelatinase related lipid delivery protein;  Prognosis
分类号:
R692
文献标志码:
A
摘要:
目的:探讨连续性肾脏替代治疗(CRRT)联合中药灌肠对重症急性肾损伤患者尿肾损伤分子-1(KIM-1)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平和预后的影响。方法:回顾性分析89例重症急性肾损伤患者临床资料,依据不同治疗方式分为对照组43例和研究组46例,对照组采用CRRT治疗,研究组采用CRRT联合中药灌肠治疗。比较两组尿量恢复时间、重症医学科(ICU)住院时间、治疗前后肾功能、尿KIM-1、NGAL水平,序贯器官衰竭估计评分(SOFA)、急性生理与慢性健康评分表(APACHEⅡ)评分和预后情况。结果:研究组尿量恢复时间、ICU住院时间均少于对照组(P<0.05)。治疗前,两组肾功能、尿KIM-1、NGAL水平,SOFA、APACHEⅡ评分比较,差异无统计学意义(P>0.05); 治疗后,两组肾功能指标、尿KIM-1、NGAL水平,SOFA、APACHEⅡ评分均较治疗前下降,研究组低于对照组,差异有统计学意义(P<0.05)。研究组死亡率较对照组低(P<0.05)。结论:CRRT联合中药灌肠能够促进重症急性肾损伤患者肾功能的恢复,降低尿KIM-1、NGAL水平,改善预后。
Abstract:
Objective:To investigate the effect of continuous renal replacement therapy(CRRT)combined with traditional Chinese medicine enema on the level and prognosis of urinary renal injury molecule-1(KIM-1),neutrophil gelatinase related lipid delivery protein(NGAL)in patients with severe acute renal injury.Methods:The clinical data of 89 patients with severe acute renal injury were analyzed retrospectively.According to different treatment methods,they were divided into control group(n=43)and study group(n=46).The control group was treated with CRRT,and the study group was treated with CRRT and traditional Chinese medicine.The recovery time of urine volume,hospitalization time of ICU,renal function,urinary KIM-1,NGAL level,sequential organ failure assessment score(sofa),acute physiology and chronic health score(APACHE Ⅱ)and prognosis were compared between the two groups.Results:The recovery time of urine volume and ICU hospitalization time in the study group were shorter than those in the control group(P<0.05).Before treatment,there was no significant difference in renal function,urinary KIM-1,NGAL level,sofa,APACHE II scores between the two groups(P>0.05); after treatment,the renal function index,urinary KIM-1,NGAL level,sofa,APACHE II scores of the two groups were lower than before treatment,the difference was statistically significant(P<0.05).The mortality rate of the study group was lower than that of the control group(P<0.05).Conclusion:CRRT combined with traditional Chinese medicine enema can promote the recovery of renal function in patients with severe acute renal injury,reduce the level of urinary KIM-1 and NGAL,and improve the prognosis.

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备注/Memo

备注/Memo:
*湖北省卫生健康委员会联合基金资助项目(WJ2018H0198)
更新日期/Last Update: 2020-03-31