[1]李英会,张 瑾,杨环玮,等.加味取渊汤治疗痰热郁肺型上气道咳嗽综合征疗效及对患儿免疫功能和血清IL-6、TNF-α水平的影响*[J].陕西中医,2020,(3):308-311.
　LI Yinghui,ZHANG Jin,YANG Huanwei,et al.Efficacy of modified Quyuan decoction in treatment of children upper airway cough symptom complex with syndrome of phlegm and heat accumulated in lung and its effect on immune function and serum levels of IL-6 and TNF-α[J].,2020,(3):308-311.
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加味取渊汤治疗痰热郁肺型上气道咳嗽综合征疗效及对患儿免疫功能和血清IL-6、TNF-α水平的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年3期
页码:
308-311
栏目:
临床研究
出版日期:
2020-03-05

文章信息/Info

Title:
Efficacy of modified Quyuan decoction in treatment of children upper airway cough symptom complex with syndrome of phlegm and heat accumulated in lung and its effect on immune function and serum levels of IL-6 and TNF-α
文章编号:
DOI:10.3969/j.issn.10007369.2020.03.010
作者:
李英会1; 张 瑾1; 杨环玮1; 朱立春1; 刘呈祥1; 王凤玲2
1.河北省秦皇岛市中医医院(秦皇岛 066000); 2.河北联合大学中医学院(唐山 063000)
Author(s):
LI Yinghui; ZHANG Jin; YANG Huanwei; et al.
Qinhuangdao Traditional Chinese Medicine Hospital in Hebei Province(Qinhuangdao 066000)
关键词:
上气道咳嗽综合征;  取渊汤;  免疫功能;  白细胞介素-6;  肿瘤坏死因子-α
Keywords:
Upper airway cough symptom complex;  Quyuan decoction;  Immune function;  Interleukin-6;  Tumor necrosis factor-α
分类号:
R256.11
文献标志码:
A
摘要:
目的:探讨加味取渊汤对痰热郁肺型上气道咳嗽综合征患儿的疗效以及对免疫功能、血清白细胞介素(IL)-6和肿瘤坏死因子(TNF)-α水平的影响。方法:将上气道咳嗽综合征患儿122例按随机数字表分为对照组和观察组,各61例。对照组患儿接受孟鲁司特钠咀嚼片; 观察组患儿西医治疗与对照组相同,并接受加味取渊汤治疗。连续治疗两周后,比较两组上气道咳嗽综合征症状体征和痰热郁肺证症状评分、临床疗效、免疫功能以及血清IL-6、TNF-α水平。结果:治疗后观察组患儿上气道咳嗽综合征症状体征、痰热郁肺证症状评分明显低于对照组(P<0.01)。观察组的总有效率95.08%显著高于对照组80.33%(P<0.05)。治疗后,观察组患儿CD3+(59.87±8.04)%、CD4+(43.09±6.03)%明显高于对照组,CD8+(26.81±4.01)%以及血清IL-6(40.03±5.21)ng/L、TNF-α(43.90±6.33)ng/L水平显著低于对照组[(56.11±7.94)%、(38.44±5.36)%、(30.45±5.23)%、(44.39±6.13)ng/L、(53.04±7.12)ng/L](P<0.01)。结论:在常规治疗基础上,加味取渊汤治疗痰热郁肺型上气道咳嗽综合征患儿的疗效显著,且可有效改善患儿的免疫功能以及抑制血清IL-6、TNF-α水平。
Abstract:
Objective:To investigate the efficacy of modified Quyuan decoction in treating children upper airway cough symptom complex with syndrome of phlegm and heat accumulated in lung and the effect on immune function and serum levels of interleukin(IL)-6 and tumor necrosis factor(TNF)-α.Methods:122 airway cough syndrome children were divided into control group and observation group with 61 cases for each group referring to the random number table.The control group received montelukast sodium chewable tablets.The observation group was given with the same western medicine treatment with the control group and modified Quyuan decoction.After 2 weeks' treatment,scores of the symptoms and signs of upper airway cough syndrome,symptom of syndrome of phlegm and heat accumulated in lung,the clinical efficacy,immune function,and serum IL-6 and TNF-α were compared between the two groups.Results:After treatment,scores of symptoms and signs of upper airway cough syndrome and symptoms of syndrome of phlegm and heat accumulated in lung were significantly lower than those of the control group(P<0.01).The total effective rate of the observation group(95.08%)was obviously higher than the control group(80.33%)(P<0.05).After treatment,CD3+(59.87±8.04)% and CD4+(43.09±6.03)% in the observation group were significantly higher,while CD8+(26.81±4.01)% and serum levels of IL-6(40.03±5.21)ng/L and TNF-α(43.90±6.33)ng/L were significantly lower,than those in the control group[(56.11±7.94)%,(38.44±5.36)%,(30.45±5.23)%,( 44.39±6.13)ng/L,(53.04±7.12)ng/L](P<0.01).Conclusion:On basis of the routine therapy,the efficacy of modified Quyuan decoction in treating children upper airway cough symptom complex with syndrome of phlegm and heat accumulated in lung is significant,and can improve immune function and inhibit serum levels of IL-6 and TNF-α.

参考文献/References:

[1] 范亚丽.自拟通窍止咳汤治疗儿童上气道咳嗽综合征临床疗效评价[J].辽宁中医药大学学报,2019,21(5):126-129.
[2] 陈 星,孙 钢.上气道咳嗽综合征临证思路撷要[J].江苏中医药,2019,51(7):42-45.
[3] 孙恒岩,洪 青.取渊汤合外用苍耳散治疗鼻渊42例[J].山东中医杂志,2010,29(6):381.
[4] 朱 彤,李 娜.孟鲁司特联合热毒宁治疗上气道咳嗽综合征对机体免疫功能的影响[J].河北医药,2017,39(4):488-491.
[5] 曹瑶凡.小儿肺热咳喘口服液辅助治疗上气道咳嗽综合征患儿临床研究[J].亚太传统医药,2019,15(2):150-152.
[6] 中华医学会儿科学分会呼吸学组慢性咳嗽协作组.中国儿童慢性咳嗽诊断与治疗指南(2013 年修订)[J].中华儿科杂志,2014,52(3):184-188.
[7] 中华中医药学会内科分会肺系病专业委员会.咳嗽中医诊疗专家共识意见(2011版)[J].中医杂志,2011,52(10):896-899.
[8] 王勇泉.耳鼻咽喉科学[M].北京:人民卫生出版社,2002:61.
[9] 国家中医药管理局.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:54-58.
[10] 彭 真,向希雄.向希雄教授运用通鼻止咳方治疗儿童上气道咳嗽综合征的临证经验[J].中医儿科杂志,2017,13(15):17-19.
[11] 张卓然,靳 伟,陈 杰.上气道咳嗽综合征患者Th1、Th2细胞表达水平研究[J].中华哮喘杂志:电子版,2011,5(4):247-249.
[12] 罗伟贤,周鸿飞.不同针刺频率对稳定期慢性阻塞性肺疾病患者呼吸功能及免疫状态的影响[J].世界中医药,2018,13(11):2839-2842.
[13] Xiong W,Liu ZG,Xiong L,et al.CD3+,CD4+,and CD8+ expression in cells in peripheral blood of silicosis patients and intervention effect of thymalfasin[J].Clin Lab Sci,2019,49(3):368-371.
[14] 何 咏.清肺化痰汤治疗120例喘证患者疗效及对肺功能、血清CPR、IL-6、IL-10影响研究[J].陕西中医,2018,39(6):733-735.
[15] 唐贤豪,张徐非,张进兴,等.加味喉科六味汤对上气道咳嗽综合征大鼠血清IL-6、IL-8、TNF-α的影响[J].中国中医药科技,2019,26(5):666-669.
[16] 李文军,唐齐兵,常 红,等.噻托溴铵辅助下双水平气道正压通气对慢性阻塞性肺疾病患者血清MMP-9、TNF-α的影响[J].中华肺部疾病杂志:电子版,2017,10(6):718-722.
[17] 郭晓雅,宋立强,梁家宁,等.钙激活Cl-通道蛋白在急性呼吸窘迫综合征患者体外气道上皮细胞中的表达及其作用实验研究[J].陕西医学杂志,2019,48(3):289-292,296.

备注/Memo

备注/Memo:
*国家自然科学基金资助项目(81303046)；河北省秦皇岛市科学技术研究与发展计划项目(201805A157)
更新日期/Last Update: 2020-04-07