[1]王 舒,林 森△,杨韵秋,等.一贯煎联合多烯磷脂酰胆碱治疗抗结核药物所致肝损伤疗效研究*[J].陕西中医,2020,(3):328-330.
　WANG Shu,LIN Sen,YANG Yunqiu,et al.Study on the therapeutic effect of Yiguanjian decoction combined with polyene phosphatidylcholine on liver injury caused by antituberculosis drugs[J].,2020,(3):328-330.
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一贯煎联合多烯磷脂酰胆碱治疗抗结核药物所致肝损伤疗效研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年3期
页码:
328-330
栏目:
临床研究
出版日期:
2020-03-05

文章信息/Info

Title:
Study on the therapeutic effect of Yiguanjian decoction combined with polyene phosphatidylcholine on liver injury caused by antituberculosis drugs
文章编号:
DOI:10.3969/j.issn.10007369.2020.03.016
作者:
王 舒; 林 森△; 杨韵秋; 杨丹丹
云南省传染病医院中医科(昆明650301)
Author(s):
WANG Shu; LIN Sen; YANG Yunqiu; et al.
Department of Traditional Chinese Medicine,Yunnan Infectious Diseases Hospital(Kunming 650301)
关键词:
肝损伤;  抗结核药物;  一贯煎;  多烯磷脂酰胆碱;  肝功能;  胆红素;  临床效果
Keywords:
Liver injury;  Antituberculosis drugs;  Yiguanjian decoction;  Polyene phosphatidylcholine;  Liver function;  Bilirubin;  Clinical effect
分类号:
R256.4
文献标志码:
A
摘要:
目的:研究一贯煎联合多烯磷脂酰胆碱治疗抗结核药物所致肝损伤的疗效。方法:76例抗结核药物所致肝损伤患者按照治疗方案分为两组,对照组38例采用多烯磷脂酰胆碱治疗,观察组38例采用一贯煎联合多烯磷脂酰胆碱治疗。将两组的临床效果进行比对。结果:观察组抗结核药物所致肝损伤患者的临床总有效率高于对照组,治疗后治疗组的ALT(40.53±7.76)U/L、AST(43.79±10.46)U/L、ALP(187.13±48.44)IU/L、GGT(109.73±26.81)IU/L、TBiL(17.20±4.26)μmol/L、DBiL(10.21±4.53)μmol/L、TBA(2.08±1.11)g/L水平均低于对照组(P<0.05)。两组患者的不良反应发生率进行比较,差异无统计学意义(P>0.05)。结论:对抗结核药物所致肝损伤患者采用一贯煎联合多烯磷脂酰胆碱治疗有效,有助于患者肝功能、胆红素水平的改善。
Abstract:
Objective:To study the curative effect of Yiguanjian combined with polyene phosphatidylcholine in the treatment of liver injury caused by antituberculous drugs.Methods:76 cases of liver injury caused by antituberculous drugs were divided into two groups according to the treatment plan.38 cases in the control group were treated with polyene phosphatidylcholine,38 cases in the observation group were treated with Yiguanjian decoction and polyene phosphatidylcholine.The clinical effects of the two groups were compared.Results:The total clinical effective rate of the observation group was significantly higher than that of the control group,and the levels of ALT(40.53 ± 7.76)U / L,AST(43.79 ± 10.46)U / L,ALP(187.13 ± 48.44)IU / L,GGT(109.73 ± 26.81)IU / L,TBIL(17.20 ± 4.26)μ mol / L,DBIL(10.21 ± 4.53)μ mol / L and TBA(2.08 ± 1.11)g / L were lower than those of the control group statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P> 0.05).Conclusion:It is effective to treat the liver injury caused by antituberculous drugs with Yiguanjian decoction and polyene phosphatidylcholine,which is helpful to improve the liver function and bilirubin level of the patients.

参考文献/References:

[1] 吴小东.多烯磷脂酰胆碱治疗抗结核药物致药物性肝炎疗效观察[J].临床合理用药杂志,2017,10(4):88-89.
[2] 张海生,陈瑞烈.双环醇联合还原型谷胱甘肽对抗结核药物性肝炎患者肝功能及氧化应激反应的影响[J].临床医学工程,2019,26(10):1397-1398.
[3] 赵 琳,任郭侠,张锦博,等.自拟肝痹汤联合多烯磷脂酰胆碱治疗抗结核药所致急性药物性肝炎的临床观察[J].中国中医急症,2019,28(9):1641-1643.
[4] 中华医学会结核病学分会.肺结核诊断和治疗指南[J].中华结核和呼吸杂志,2001,20(2):70-74.
[5] 林厚雄,黄修柳,王德志.双环醇和多烯磷脂酰胆碱治疗抗结核药物性肝损伤疗效比较[J].山东医药,2019,59(22):69-71.
[6] 平利峰,姜淑华,孙凤艳,等.一贯煎组方联合还原型谷胱甘肽治疗干燥综合征肝损伤的疗效及对肝功能的影响[J].检验医学与临床,2018,15(6):854-856.
[7] 刘林涛,曹 丽.异甘草酸镁对抗结核药物引起药物性肝炎的效果观察[J].深圳中西医结合杂志,2018,28(16):147-148.
[8] 王 丽.甘草酸二铵、多烯磷脂酰胆碱对抗结核药物所致肝损伤的保护作用比较[J].海南医学院学报,2016,22(20):2490-2493.
[9] 魏明禄,刘建民,陈南清,等.滋肾益肝方联合多烯磷脂酰胆碱治疗抗结核药物所致急性肝损伤的有效性与安全性研究[J].中华中医药学刊,2018,36(1):45-48.
[10] 徐京杭.多烯磷脂酰胆碱在肝病临床应用的专家共识[J].临床消化病杂志,2017,29(6):331-338.
[11] 甘楚林,李剑鹏.抗结核药致药物性肝炎的治疗效果评估及研究[J].中国医药导刊,2017,19(4):384-385.
[12] 杨晨敏,李 健.还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝病的临床疗效及对肝功能的影响[J].中国医药导刊,2015,17(12):1261-1262.
[13] 尚品杰.还原型谷胱甘肽联合多烯磷脂酰胆碱治疗急性药物性肝损伤效果分析[J].河南医学研究,2017,26(15):2776-2777.
[14] 沈小波,李四清.百合固金汤联合抗结核西药对肺结核患者IL-2、IL-6和TNF-α水平的影响[J].陕西中医,2018,39(2):190-192.
[15] 徐 辉,高志文,刘 健,等.多烯磷脂酰胆碱胶囊联合还原型谷胱甘肽治疗抗结核药物致肝损伤患者的临床疗效[J].实用医院临床杂志,2018,15(4):164-167.
[16] 闫嘉亮.一贯煎联合复方甘草酸苷片治疗抗结核药物所致肝损伤疗效观察[J].中国中医药现代远程教育,2018,16(20):60-62.

备注/Memo

备注/Memo:
*云南省卫生科技计划项目(2018NS0159)
更新日期/Last Update: 2020-04-07