参考文献/References:
[1] Pankiv S,Clausen TH,Lamark T,et al.P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy[J].J Biol Chem,2007,282(33):24131-24145.
[2] Matsuzawa Y,Oshima S,Nibe Y,et al.RIPK3 regulates P62-LC3 complex formation via the caspase-8-dependent cleavage of P62[J].Biochem Biophys Res Commun,2015,456(1):298-304.
[3] 胡跃强,兰 鹏,梁 妮,等.清热化瘀方治疗急性中风的临床疗效观察及其作用机制研究[J].辽宁中医杂志,2017,44(10):2105-2107.
[4] 胡跃强,唐 农,雷龙鸣,等.大鼠脑缺血预处理后PERK表达的变化及清热化瘀方的干预研究[J].时珍国医国药,2012,23(6):1332-1334.
[5] Geisler S,Holmstrom KM,Skujat D,et al.PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and P62/SQSTM1[J].Nat Cell Biol,2010,12(2):119-131.
[6] Kouroku Y,Fujita E,Tanida I,et al.ER stress(PERK/eIF2a phosphorylation)mediates the polyglutamine- induced LC3 conversion,an essential step for autophagy formation[J].Cell Death Differ,2007,14(2):230- 239.
[7] Kirkin V,McEwan DG,Novak I,et al.A role for ubiquitin in selective autophagy [J].Mol Cell,2009,34:259-269.
[8] Komatsu M,Waguri S,Koike M,et al.Homeostatic levels of P62 control cytoplasmic inclusion body formation in autophagy-deficient mice[J].Cell,2007,131(6):1149-1163.
[9] BenYounes A,Tajeddine N,Tailler M,et al.A fluorescence -microscopic and cytofluorometric system for monitoring the turnover of the autophagic substrate P62/SQSTM1[J].Autophagy,2011,7(8):883-891.
[10] Mizushima N.Methods for monitoring autophagy [J].Int J Biochem Cell Biol,2004,36(12):2491-2502.
[11] Liu C,Chen S,Kamme F,et al.Ischemic preconditioning prevents protein aggregation after transient cerebral ischemia[J].Neuroscience,2005,134(1):69-80.
[12] Bae N,Chung S,Kim HJ,et al.Neuroprotective effect of modified Chungsimyeolda-tang,a traditional Korean herbal formula,via autophagy induction in models of Parkinson's disease [J].J Ethnopharmacol,2015,159:93-101.
[13] Liu H,Qiu H,Xiao Q,et al.Chronic hypoxia-induced autophagy aggravates the neuropathology of Alzheimer's disease through AMPK-mTOR signaling in the APPSwe/PS1dE9 mouse model [J].J Alzheimer'sDis,2015,48(4):1019-1032.
[14] 祝美珍,胡国恒,肖艳芬,等.淤痰热毒并治抗急性脑缺血损伤的策略探究[J].时珍国医国药,2009,20(2):392-393.
[15] 胡跃强,胡国恒,吴云虎,等.清热化瘀颗粒治疗急性脑梗死临床观察[J].辽宁中医杂志,2004,20(7):65-67.
[16] 胡跃强,陈海峰,唐 农,等.缺氧预处理MSCs移植对脑缺血损伤大鼠SDF-1/CXCR4表达的影响及清热化瘀方的干预研究[J].中药新药与临床药理杂志,2016,27(6):779-784.
[17] Wen YD,Sheng R,Zhang LS,et al.Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways[J].Autophagy,2008,4(6):762-769.
[18] Wang JY,Xia Q,Chu KT,et al.Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat isprevented by 3-Methyladenine:a widely used inhibitor of autophagy[J].J Neuropathol Exp Neurol,2011,70(4):314-322.