[1]安建峰,孙 烨,刘季元△.化瘀调脂方对高脂血症大鼠降脂作用的实验研究*[J].陕西中医,2020,(4):440-442.
　AN Jianfeng,SUN Ye,LIU Jiyuan..Experimental study of Huayu Tiaozhi recipe on lipi-lowering in hyperlipidemia model rats[J].,2020,(4):440-442.
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化瘀调脂方对高脂血症大鼠降脂作用的实验研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年4期
页码:
440-442
栏目:
基础研究
出版日期:
2020-04-05

文章信息/Info

Title:
Experimental study of Huayu Tiaozhi recipe on lipi-lowering in hyperlipidemia model rats
文章编号:
DOI:10.3969/j.issn.10007369.2020.04.010
作者:
安建峰1; 孙 烨2; 刘季元3△
1.西安交通大学附属西安市儿童医院中西医结合科(西安710002); 2.西安交通大学第一附属医院中医科(西安710061); 3.陕西省中医医院老年病科(西安710003)
Author(s):
AN Jianfeng;  SUN Ye;  LIU Jiyuan.
Department of Integrated TCM & Western Medicine,Xi'an Children's Hospital(Xi'an 710002)
关键词:
化瘀调脂方;  血清TG;  血清TC;  NO;  SOD;  血管内皮;  大鼠
Keywords:
Huayu Tiaozhi recipe;  serum TG;  Serum TC;  NO;  SOD;  Vascular endothelium;  Rats
分类号:
R589.2
文献标志码:
A
摘要:
的:观察不同剂量化瘀调脂方对高脂血症大鼠的降脂效果及对血清NO、SOD的影响。方法:将60只SD雄性健康大鼠利用随机数字表分为空白对照组、模型组、化瘀调脂方高、中、低剂量组及非诺贝特组,采用高脂饲料喂养法造模成功后,实验组予不同剂量化瘀调脂方灌胃、非诺贝特组给予非诺贝特灌胃、空白对照组和模型组予等体积生理盐水灌胃。给药4周后,测定甘油三酯(TG)、血清胆固醇(TC)及血清NO含量和SOD活力。结果:①化瘀调脂方高、中、低剂量组及非诺贝特组血清TG、TC水平明显低于模型组(P<0.05); 化瘀调脂方高剂量组降低血清TG水平与非诺贝特组差异无统计学意义(P>0.05),降低血清TC水平与非诺贝特组差异有统计学意义(P<0.05)。② 模型组大鼠血清NO、SOD明显低于空白组(P<0.01),化瘀调脂方高、中、低剂量组及非诺贝特组血清NO、SOD水平明显高于模型组(P<0.01、P<0.05)。高剂量组NO水平高于中、低剂量组及非诺贝特组(P<0.05)。结论: 化瘀调脂方具有降低高脂血症大鼠血脂的作用,并能提高SOD活性、升高血清NO水平,且具有一定量效关系。
Abstract:
Objective:To observe the lipid-lowering effects of different dosages of Huayu Tiaozhi recipe on hyperlipidemia rats and the effects on serum NO and SOD.Methods:Sixty SD male healthy rats were randomly divided into blank control group,model group,Huayu Tiaozhi recipe high,medium and low dose group and fenofibrate group by random number table method.A hyperlipidemia model was established with high-fat diet.After successful modeling,the experimental group was given different doses of Huayu Tiaozhi recipe,the fenofibrate group was given fenofibrate gavage,and the blank control group and model group were given the same volume of saline.After 4 weeks of administration,the levels of serum triglyceride(TG),serum cholesterol(TC),serum NO content and SOD activity were measured.Results:① Serum TG and TC levels of Huayu Tiaozhi recipe in high-dose,medium-dose and low-dose groups and fenofibrate group were significantly lower than those in model group(P<0.05); high-dose group reduced serum TG level and fenofibrate group was no difference(P>0.05),and the serum TC level was different from the fenofibrate group(P<0.05).② The serum NO and SOD in the model group were significantly lower than those in the blank group(P<0.01),and the serum NO and SOD levels in the high-dose,medium-dose,and low-dose groups of Huayu Tiaozhi recipe and fenofibrate were significantly higher than those in the model group(P<0.01,P<0.05).The level of NO in the high-dose group was higher than that in the middle-dose,low-dose and fenofibrate groups(P<0.05).Conclusion:Huayu Tiaozhi recipe has the effect of reducing blood lipids in hyperlipidemia rats,and can increase SOD activity,serum NO level,and has a dose-effect relationship.

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备注/Memo

备注/Memo:
*陕西省科技计划项目(2019SF-311)
更新日期/Last Update: 2020-04-13