[1]余 萌,刘慧玲,王昊阳.醒胰汤保留灌肠联合西药治疗急性重症胰腺炎疗效及对患者血清淀粉酶和胃肠动力学的影响*[J].陕西中医,2020,(4):505-508.
　YU Meng,LIU Huiling,WANG Haoyang..Curative effect of Xingyi decoction retention enema combined with western medicine on acute severe pancreatitis and their influences on serum amylase and gastrointestinal dynamics[J].,2020,(4):505-508.
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醒胰汤保留灌肠联合西药治疗急性重症胰腺炎疗效及对患者血清淀粉酶和胃肠动力学的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年4期
页码:
505-508
栏目:
临床研究
出版日期:
2020-04-05

文章信息/Info

Title:
Curative effect of Xingyi decoction retention enema combined with western medicine on acute severe pancreatitis and their influences on serum amylase and gastrointestinal dynamics
文章编号:
DOI:10.3969/j.issn.10007369.2020.04.031
作者:
余 萌; 刘慧玲; 王昊阳
四川大学华西医院上锦医院(成都上锦南府医院)中西医结合科(成都 611731)
Author(s):
YU Meng;  LIU Huiling; WANG Haoyang.
Department of Integrated Traditional Chinese and Western Medicine,Shangjin Hospital of Huaxi Hospital Sichuan University(Chengdu 611731)
关键词:
急性重症胰腺炎;  醒胰汤;  保留灌肠;  血清淀粉酶;  胰脂肪酶;  胃肠动力学
Keywords:
Xingyi decoction;  Retention enema;  Western medicine;  Acute severe pancreatitis;  Serum amylase;  Pancreatic lipase;  Gastrointestinal dynamics
分类号:
R657.51
文献标志码:
A
摘要:
目的:探讨醒胰汤保留灌肠联合西药治疗急性重症胰腺炎(ASP)的疗效及对患者血清淀粉酶(AMY)和胃肠动力学的影响。方法:收集ASP患者160例,依据治疗方式分为A组(西医常规治疗)和B组(醒胰汤保留灌肠联合西药),治疗1周后,比较两组患者临床疗效,血清AMY、血钙(Ca)以及胰脂肪酶(LPS)水平变化,胃肠动力学指标变化,血清炎性因子变化,临床症状恢复时间及住院时间,不良反应发生情况。结果:B组总有效率为93.75%(75/80)显著高于A组80.00%(64/80)(P<0.05); B组血清AMY及LPS水平显著低于A组(P<0.05),Ca水平均显著高于A组(P<0.05); B组OCTT、GAS水平显著低于A组(P<0.05),MTL、VIP水平显著高于A组(P<0.05); B组的肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素8(IL-8)水平均显著低于A组(P<0.05),白细胞介素10(IL-10)显著高于A组(P<0.05); B组患者腹痛缓解时间、发热缓解时间、腹胀缓解时间、肠鸣音恢复时间、禁食时间以及住院时间均较A组显著缩短(P<0.05); B组患者治疗期间不良反应总发生率与A组无显著差异(P>0.05)。结论:醒胰汤保留灌肠联合西药治疗ASP能够有效提高患者临床总有效率,调节血清AMY等实验室相关指标,降低促炎因子水平,促进其临床症状缓解,加快康复进程。
Abstract:
Objective:To investigate the curative effect of Xingyi decoction retention enema combined with western medicine on acute severe pancreatitis(ASP)and their influences on serum amylase(AMY)and gastrointestinal dynamics.Methods:A total of 160 ASP patients were enrolled.They were divided into group A(Western medicine routine treatment)and group B(Xingyi decoction retention enema combined with western medicine)according treatment methods.After 1 week of treatment,the clinical curative effect,changes in levels of serum AMY,serum calcium(Ca)and pancreatic lipase(LPS),gastrointestinal dynamics indexes and serum inflammatory factors,recovery time of clinical symptoms,hospitalization time,and occurrence of adverse reactions were compared between the two groups.Results:The total response rate of group B was significantly higher than that of group A [93.75%(75/80)vs (80.00%(64/80)](P<0.05).The levels of serum AMY and LPS in group B were significantly lower than those in group A(P<0.05),while Ca level was significantly higher than that in group A(P<0.05).The levels of OCTT and GAS in group B were significantly lower than those in group A(P<0.05),while levels of MTL and VIP were significantly higher than those in group A(P<0.05).The levels of tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in group B were significantly lower than those in group A(P<0.05),while interleukin-10(IL-10)was significantly higher than that in group A(P<0.05).The remission time of abdominal pain,remission time of fever,remission time of abdominal distension,recovery time of gurgling sound,fasting time and hospitalization time in group B were significantly shorter than those in group A(P<0.05)There was no significant difference in total incidence of adverse reactions during treatment between group B and group A(P>0.05).Conclusion:Xingyi decoction retention enema combined with western medicine for ASP can effectively improve total clinical response rate of patients,regulate laboratory related indexes such as serum AMY,reduce pro-inflammatory factors levels,promote remission of clinical symptoms,and accelerate recovery process.

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备注/Memo

备注/Memo:
*四川省科技厅重点研发项目(2019YFS0259)
更新日期/Last Update: 2020-04-13