[1]肖雅瑜,曾普华△,郜文辉,等.曾普华教授辨治胰腺癌特色探析*[J].陕西中医,2020,(5):667-669,681.[doi:DOI:10.3969/j.issn.10007369.2020.05.032]
 XIAO Yayu,ZENG Puhua,GAO Wenhui,et al.Analysis on the characteristics of professor Zeng Puhua's treatment of pancreatic cancer based on syndrome differentiation[J].,2020,(5):667-669,681.[doi:DOI:10.3969/j.issn.10007369.2020.05.032]
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曾普华教授辨治胰腺癌特色探析*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年5期
页码:
667-669,681
栏目:
名老中医经验
出版日期:
2020-05-05

文章信息/Info

Title:
Analysis on the characteristics of professor Zeng Puhua's treatment of pancreatic cancer based on syndrome differentiation
作者:
肖雅瑜1 曾普华2△ 郜文辉1 何凤姣2李克雄1
1.湖南中医药大学(长沙 410208); 2.湖南省中医药研究院(长沙 410026)
Author(s):
XIAO YayuZENG PuhuaGAO Wenhui et al.
Hunan University of Traditional Chinese Medicine(Changsha 410208)
关键词:
胰腺癌 癌毒致虚 用药特色 中医药治疗 名医经验 曾普华
Keywords:
Pancreatic cancer Cancer-toxicogenic deficiency Characteristic use of traditional Chinese medicine Chinese medicine treatment Famous doctor experience Zeng Puhua
分类号:
R273
DOI:
DOI:10.3969/j.issn.10007369.2020.05.032
文献标志码:
A
摘要:
本文旨在探析曾普华教授基于“癌毒致虚”理论,治疗胰腺癌的辨治思路及临床用药特色。基于“癌毒致虚”理论及临床经验,曾师认为胰腺癌以“肝郁脾虚、毒瘀互结”为主,常兼夹湿热内蕴、水湿内停、胃失和降、气血亏虚、肝肾不足等证,当以“疏肝健脾、解毒化瘀”为基本治法,配合清热利湿、利水消肿、降逆和胃、补益气血、滋补肝肾等法。曾师认为胰腺癌早期治疗以疏肝健脾、解毒化瘀为主; 中期以扶正培本、解毒化瘀为主; 晚期以扶正培本为主,解毒化瘀为辅。基于“癌毒致虚”理论及临床经验,肝脾并治,多脏调燮,特色用药,在临床上已获得较好的疗效。
Abstract:
The purpose of this paper is to analyze Professor Zeng Puhua's thinking of the treatment and the characteristics of clinical medication of pancreatic cancer based on the theory of “cancer-toxicogenic deficiency”.Based on the theory and clinical experience of cancer-induced deficiency,Professor Zeng believes that pancreatic cancer is mainly characterized by “liver-stagnation and spleen-deficiency,combination of toxin and stagnation”,often accompanied with the syndromes of endoretention of damp-heat,internal stop of dampness,rise and fall misalignment of stomach Qi,deficiency of qi and blood and deficiency of liver and kidney.The basic treatment method is to “soothing liver and strengthening spleen,detoxifying and removing blood statis”,in combination with clearing heat-toxicity and eliminating dampness,inducing diuresis and alleviating edema,calming the adverse-rising energy and attempering stomach,tonifying Qi and blood,nourishing liver and kidney,etc.Professor Zeng deems that the early treatment of pancreatic cancer is mainly based on soothing liver and strengthening spleen,detoxifying and removing blood statis.In the middle stage,reinforcing the vital energy and consolidating the constitution,simultaneously detoxifying and removing blood statis.In the terminal stage,reinforcing the vital energy and consolidating the constitution is primary,and detoxifying and removing blood statis is secondary.Based on the theory and clinical experience of “cancer-toxicogenic deficiency”,the combined treatment of liver and spleen,multiple visceral adjustment and characteristic use of traditional Chinese medicine have obtained good clinical effect.

参考文献/References:

[1] Zeng H,Chen W,Zheng R,et al.Changing cancer survival in China during 2003-15:a pooled analysis of 17 population-based cancer registries[J].Lancet Glob Health,2018,6(5):555-567.
[2] Rahib L,Smith BD,Aizenberg R,et al.Projecting cancer incidence and deaths to 2030:the unexpected burden of thyroid,liver,and pancreas cancers in the United States[J].Cancer Res,2014,74(11):2913-2921.
[3] 程海波,吴勉华.周仲瑛教授“癌毒”学术思想探析[J].中华中医药杂志,2010,25(6):866-869.
[4] 张 振,郜文辉,王亚琪,等.益气化瘀解毒方加减联合索拉非尼治疗原发性肝癌疗效研究[J].陕西中医,2019,40(3):322-324.
[5] 郜文辉,曾普华,潘敏求,等.益气化瘀解毒方含药血清对鸡胚尿囊膜血管生成的影响[J].中华中医药学刊,2013,31(1):19-20.
[6] 曾普华,郜文辉,潘敏求,等.益气化瘀解毒方加减联合鸦胆子油乳经血管介入治疗中晚期原发性肝癌的临床研究[J].辽宁中医杂志,2013,40(1):18-21.
[7] 张 瑜,郑作文.八月札抗肿瘤作用的初步研究[J].广西中医药大学学报,2016,19(3):9-10.
[8] 吴 蒙,姚开泰.木香内酯抑制肺癌细胞H460生长的机制研究[J].医学研究生学报,2017,30(9):932-936.
[9] 曾普华,叶书林,王佳佳,等.重楼皂苷Ⅰ对人肝癌细胞MHCC97-H增殖、周期、凋亡的影响[J].云南中医学院学报,2017,40(3):7-10.
[10] 秦 勇,马清涌,党晓燕,等.白藜芦醇抑制胰腺癌裸鼠移植瘤生长的实验研究[J].陕西医学杂志,2016,45(10):1275-1278.
[11] 郭梦丽,王建刚,靳 颖.壁虎醇提物对H22肝癌血管新生的抑制作用[J].中国临床药理学杂志,2016,32(24):2282-2285.
[12] 李道睿,王苗苗,于明薇,等.通络活血虫类药对乏氧环境下肺癌血管生成相关细胞因子的影响[J].中国中医药信息杂志,2017,24(9):39-42.
[13] 邱 波,荆雪宁,武继彪,等.黄芪多糖诱导的树突状细胞疫苗对S180荷瘤小鼠抗肿瘤作用研究[J].南京中医药大学学报,2015,31(1):44-47.
[14] 戚 晶.茵陈蒿汤加减联合替吉奥治疗晚期胰腺癌患者的临床观察[J].光明中医,2018,33(4):563-564.
[15] 陈 辉,王兆洪,陈 龙,等.吴茱萸碱对人胰腺癌SW1990细胞株体内外增殖及凋亡的影响[J].温州医科大学学报,2017,47(6):431-434,440.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目( 81603603);湖南省科技计划项目(2016SK2051);湖南省教育厅优秀青年项目(14B135)
更新日期/Last Update: 2020-05-14