[1]严 莉,李 晶,黎玉宣,等.腹针联合脐疗对黄体功能低下型不孕症患者子宫内膜容受性的影响*[J].陕西中医,2020,(5):673-676.[doi:DOI:10.3969/j.issn.10007369.2020.05.034]
 YAN Li,LI Jing,LI Yuxuan,et al.The influence of abdominal acupuncture combined with umbilical therapy on endometrial receptivity in infertility patients caused by luteal phase deficiency[J].,2020,(5):673-676.[doi:DOI:10.3969/j.issn.10007369.2020.05.034]
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腹针联合脐疗对黄体功能低下型不孕症患者子宫内膜容受性的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年5期
页码:
673-676
栏目:
针灸经络
出版日期:
2020-05-05

文章信息/Info

Title:
The influence of abdominal acupuncture combined with umbilical therapy on endometrial receptivity in infertility patients caused by luteal phase deficiency
作者:
严 莉李 晶黎玉宣黄海燕张喜娟卫义兰
广西壮族自治区桂林市中医医院针灸科(桂林 541002)
Author(s):
YAN LiLI JingLI Yuxuanet al.
Department of Acupuncture and Moxibustion,Hospital of Traditional Chinese Medicine in Guilin(Guilin 541002)
关键词:
黄体功能低下 不孕症 腹针 脐疗 子宫内膜容受性
Keywords:
Luteal phase deficiency Infertility Abdominal acupuncture Umbilical therapy Endometrial receptivity
分类号:
R271.14
DOI:
DOI:10.3969/j.issn.10007369.2020.05.034
文献标志码:
A
摘要:
目的:探讨腹针联合脐疗对黄体功能低下型不孕症患者子宫内膜容受性的影响,旨在为临床治疗提供有力参考。方法:选择黄体功能低下型不孕症患者140例,按照随机数字表法分为对照组与观察组各70例。两组均给予常规黄体酮治疗,在此基础上,对照组给予黄体酮联合腹针治疗,观察组在对照组治疗基础上联合脐疗治疗。对比治疗前、治疗3个月经周期后两组证候总积分、子宫内膜厚度、子宫内膜血流参数[阻力指数(RI)、搏动指数(PI)]、黄体中期激素[雌二醇(E2)、孕酮(P)]及妊娠率。结果:治疗后,与对照组相比,观察组证候总积分较低,子宫内膜厚度较高,PI、RI指数较低,E2、P水平均较高,妊娠成功率较高,差异均有统计学意义(P<0.05)。结论:将腹针与脐疗联合用于黄体功能低下型不孕症患者治疗中,能够有效缓解患者临床症状,提高黄体中期雌孕激素水平,改善黄体中期血流灌注,促进子宫内膜增长,从而提高子宫内膜容受性,提高临床妊娠成功率。
Abstract:
Objective:To investigate the influence of abdominal acupuncture combined with umbilical therapy on endometrial receptivity in infertility patients caused by luteal phase deficiency,and to provide powerful reference for future clinical treatment.Methods:140 infertility patients caused by luteal phase deficiency were selected as research subjects,and they were divided into control group(n=70)and observation group(n=70)according to random number table.Two groups were given routine progesterone treatment,and on this basis,control group was treated with progesterone combined with abdominal acupuncture,and observation group was treated with umbilical therapy based on control group.The total syndrome score,endometrial thickness,endometrial blood flow parameters [resistance index(RI),pulsatility index(PI)],mid-luteal phase of hormones [estradiol(E2),progesterone(P)],and pregnancy rate before treatment and after treatment for 3 months were compared between the two groups.Results:After treatment,compared with control group,the total syndrome score in observation group was lower,the endometrial thickness in observation group was higher,the PI and RI in observation group were lower,the levels of E2and P in observation group were higher,the success rate of pregnancy in observation group was higher,and the differences were statistically significant(P<0.05).Conclusion:Abdominal acupuncture combined with umbilical therapy in treatment of infertility patients caused by luteal phase deficiency can relieve clinical symptoms,increase the levels of mid-luteal phase of estrogen and progesterone,improve mid-luteal phase of blood perfusion,promote growth of endometrium,thus increasing endometrial receptivity and the success rate of pregnancy.

参考文献/References:

[1] 黄 昕,汤春琼.中医辨证治疗不孕症临床疗效研究[J].陕西中医,2019,40(9):1219-1221.
[2] 史艳馨,魏 玮,马红霞.中西医结合治疗肾阳虚肝郁型黄体功能性不孕的临床观察[J].新疆中医药,2017,35(5):9-11.
[3] Eiza,Li R,Zheng Y,et al.Deletion of rhoa in progesterone receptor-expressing cells leads to luteal insufficiency and infertility in female mice[J].Endocrinology,2017,158(7):2168.
[4] 宋 杰,匡 野,石 佳.改善子宫内膜容受性相关措施的研究进展[J].中国医师进修杂志,2016,39(9):858-861.
[5] 牛凯迪,王春雪,于月新.反复植入失败与子宫内膜容受性标志物研究进展[J].生殖医学杂志,2019,28(8):961-964.
[6] 杨仁祥,武 泽.子宫内膜容受性的研究进展[J].实用妇产科杂志,2019,35(1):24-28.
[7] 中国医师协会生殖医学专业委员会.高龄女性不孕诊治指南[J].生殖与避孕,2017,37(2):87-100.
[8] 国家食品药品监督管理总局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:312-316.
[9] 陈贵廷,杨思澍.实用中西医结合诊断治疗学[M].北京:中国医药科技出版社,1995:61.
[10] Schulte MM,Tsai JH,Moley KH.Obesity and PCOS:the effect of metabolic derangements on endometrial receptivity at the time of implantation[J].Reprod Sci,2015,22(1):6-14.
[11] 张 媛,糜媛媛,何 晶.知柏地黄丸对卵巢储备功能低下性激素及妊娠的影响及其作用机制研究[J].世界中医药,2018,13(10):2405-2408.
[12] 李 霞,郑利芳.腹针疗法在辅助生殖技术中的应用体会[J].浙江中西医结合杂志,2017,27(3):251-253.
[13] 孟延兵,王素玲.脐灸加腹针治疗多囊卵巢综合征脾肾阳虚证的临床观察[J].云南中医中药杂志,2017,38(1):20-23.
[14] 张淑霞,刘淑文,刘玉双, 等.中药脐灸治疗输卵管通而不畅不孕症效果观察[J].现代中西医结合杂志,2019,28(26):2899-2902.
[15] 屈莉红,李红莲.脐针治疗多囊卵巢综合征不孕的临床研究[J].中国保健营养,2019,29(28):134.
[16] 郭闫萍,郑其国,孙玉国,等.口服中药配合隔药灸脐法治疗黄体功能不全性不孕症的临床研究[J].中国临床医生杂志,2018,46(3):367-370.
[17] 李昭凤,王 辉,郝明耀,等.隔药灸脐法治疗排卵障碍性不孕症:随机对照试验[J].中国针灸,2017,37(8):819-823.
[18] 袁淑芬,叶咏菊,王婷婷,等.隔药灸脐法治疗排卵障碍性不孕症67例[J].浙江中医杂志,2018,53(9):651.
[19] 卢 岩,沈庆思,田 梦,等.隔药脐疗对卵巢早衰大鼠VEGF和AMH表达的影响[J].山东中医杂志,2017,36(7):597-600.
[20] 韩兴军,王 璇.脐疗治疗肾虚血瘀型排卵障碍性不孕症的机理与临床疗效研究[J].中国中医基础医学杂志,2017,23(7):999-1000,1008.
[21] 许凤全,郑 瑀,许琳洁,等.女性更年期抑郁症与下丘脑-垂体-卵巢轴关系的研究述评[J].精神医学杂志,2016,29(1):69-72.
[22] 范强芳,柯 婵,吴晓兰.改良隔药灸脐法治疗宫寒不孕的临床观察[J].中医药导报,2018,24(16):100-102.
[23] 何晓梦,赵小卫,吕 娜.黄体酮治疗先兆流产患者前后血清中孕酮(P)和孕激素诱导阻断因子(PIBF)表达比较[J].陕西医学杂志,2017,46(3):395-397.
[24] 黄品秀,韦继红,韦立红,等.探讨最适合胚胎种植的子宫内膜厚度[J].生殖医学杂志,2016,25(3):232-236.
[25] 王秀娟,周春红,郝天羽,等.宫腔灌注改善子宫内膜容受性的研究进展.[J].实用医药杂志,2019,36(5):470-474.
[26] Dogan O,Yildiz A,Temizkan O,et al.Comparison of uterine,endometrial and ovarian blood flow by transvaginal color Doppler ultrasound in ovulatory and anovulatory cycles[J].Ginekol Pol,2016,87(8):581.

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备注/Memo

备注/Memo:
*广西壮族自治区中医药科技专项课题(GZLC16-67)
更新日期/Last Update: 2020-05-14