[1]刘 娜,尹丽鹤,赵 钢△.银杏叶提取物联合前列地尔治疗中枢性眩晕疗效及对患者血液流变学的影响*[J].陕西中医,2020,(7):868-870.[doi:DOI:10.3969/j.issn.10007369.2020.07.008]
　LIU Na,YIN Lihe,ZHAO Gang..Effect of Ginkgo biloba extract combined with alprostadil on central vertigo and its effect on patients' blood rheology[J].,2020,(7):868-870.[doi:DOI:10.3969/j.issn.10007369.2020.07.008]
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银杏叶提取物联合前列地尔治疗中枢性眩晕疗效及对患者血液流变学的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年7期
页码:
868-870
栏目:
临床研究
出版日期:
2020-07-05

文章信息/Info

Title:
Effect of Ginkgo biloba extract combined with alprostadil on central vertigo and its effect on patients' blood rheology
作者:
刘 娜1; 2; 尹丽鹤2; 赵 钢1△
1.空军军医大学第一附属医院(西安710032); 2.西安交通大学第一附属医院东院(西安710089)
Author(s):
LIU Na; YIN Lihe;  ZHAO Gang.
The First Affiliated Hospital of Air Force Medical University(Xi'an 710032)
关键词:
银杏叶提取物;  前列地尔;  中枢性眩晕;  血液流变学;  疗效;  中医证候积分
Keywords:
Ginkgo biloba extract;  Alprostadil;  Central vertigo;  Hemorheology;  Efficacy;  TCM syndrome score
分类号:
R255.3
DOI:
DOI:10.3969/j.issn.10007369.2020.07.008
文献标志码:
A
摘要:
目的:研究银杏叶提取物(GBE)联合前列地尔治疗中枢性眩晕的疗效及对患者血液流变学的影响。方法:将中枢性眩晕患者160例随机分为对照组和观察组各80例。对照组给予前列地尔注射液,观察组在对照组的基础上给予银杏叶提取物注射液。比较两组治疗前后的中医证候积分、眩晕评分和血液流变学相关指标,比较两组的治疗有效率和不良反应发生率。结果:治疗后,对照组和观察组的中医证候积分和眩晕评分,与治疗前相比,均明显降低(P<0.05),观察组的中医证候积分和眩晕评分均明显低于对照组(P<0.05)。观察组的治疗有效率明显高于对照组(P<0.05)。与治疗前相比,治疗后,两组的血浆黏度、纤维蛋白原和血细胞压积水平均明显降低(P<0.05),其中观察组血浆黏度、纤维蛋白原和血细胞压积水平均明显低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:GBE联合前列地尔治疗中枢性眩晕,能够明显改善患者的中医证候积分和血液流变学指标,降低眩晕严重程度,提高治疗效果,且安全性好。
Abstract:
Objective:The effects of Ginkgo biloba extract(GBE)combined with alprostadil on central vertigo and its effect on the hemorheology of patients were studied.Methods:A total of 160 patients with central vertigo were randomly divided into the control group and the GBE group,with 80 cases each.The control group was given alprostadil injection,and the GBE group was given Ginkgo biloba extract injection on the basis of the control group.The TCM syndrome score,vertigo score,and hemorheology-related indexes before and after treatment between the two groups were compared.The treatment efficiency and the incidence of adverse reactions were compared between the two groups.Results:After treatment,the TCM syndrome scores and dizziness scores of the control group and GBE group were significantly lower than those before treatment(P<0.05),and the TCM syndrome scores and dizziness scores of the GBE group were significantly lower than those of the control group(P<0.05).The treatment effectiveness of GBE group was significantly higher than that in control group(P<0.05).Compared with before treatment,the plasma viscosity,fibrinogen,and hematocrit levels were significantly reduced in both groups after treatment(P<0.05),and the plasma viscosity,fibrinogen,and hematocrit levels in the GBE group were significantly lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compared with alprostadil alone,GBE combined with alprostadil in the treatment of central vertigo can significantly improve the TCM syndrome score and hemorheology index of patients,reduce the severity of vertigo,improve the treatment effect,and have good safety.

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备注/Memo

备注/Memo:
*国家重点研发计划项目(2016YFC0904500)
更新日期/Last Update: 2020-07-09