[1]蒋守涛,吴永刚,叶少强,等.通阳宽胸方联合PCI治疗急性心肌梗死疗效及对患者血管内皮功能的影响*[J].陕西中医,2020,(7):871-874.[doi:DOI:10.3969/j.issn.10007369.2020.07.009]
　JIANG Shoutao,WU Yonggang,YE Shaoqiang,et al.Curative effect of Tongyang Kuanxiong recipe combined with PCI on acute myocardial infarction and their influences on vascular endothelial function[J].,2020,(7):871-874.[doi:DOI:10.3969/j.issn.10007369.2020.07.009]
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通阳宽胸方联合PCI治疗急性心肌梗死疗效及对患者血管内皮功能的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年7期
页码:
871-874
栏目:
临床研究
出版日期:
2020-07-05

文章信息/Info

Title:
Curative effect of Tongyang Kuanxiong recipe combined with PCI on acute myocardial infarction and their influences on vascular endothelial function
作者:
蒋守涛; 吴永刚; 叶少强; 聂鹏飞; 李幸洲; 吴国宝
广州市中西医结合医院心内科(广州 510800)
Author(s):
JIANG Shoutao; WU Yonggang; YE Shaoqiang; et al.
Department of Cardiology,Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine(Guangzhou 510800)
关键词:
通阳宽胸方;  急性心肌梗死;  效果;  血管内皮功能;  炎症因子;  不良事件
Keywords:
Tongyang Kuanxiong recipe;  Acute myocardial infarction;  Effect;  Vascular endothelial function;  Inflammatory factors;  Adverse event
分类号:
R542.22
DOI:
DOI:10.3969/j.issn.10007369.2020.07.009
文献标志码:
A
摘要:
目的:通阳宽胸方联合PCI治疗急性心肌梗死的效果及对血管内皮功能的影响。方法:选取急性心肌梗死患者80例作为研究对象,按照随机编号法分为对照组和观察组,每组40例,对照组给予PCI治疗,观察组给予通阳宽胸方联合PCI治疗,比较两组患者治疗后的临床症状改善情况、疗效、血管内皮功能、炎性因子水平、不良心血管事件的发生情况。结果:治疗前两组患者的中医症候积分比较差异无统计学意义(P>0.05),治疗后观察组胸闷乏力、心悸气短、吐痰涎、头重如裹、眩晕等中医症候积分明显低于对照组,两组比较差异有统计学意义(P<0.05); 观察组治疗有效率为95.00%显著高于对照组77.50%,两组比较差异有统计学意义(P<0.05); 治疗前两组患者的一氧化氮(NO)、超氧化物歧化酶(SOD)、血栓素(TXB2)、内皮素(ET)水平比较差异无统计学意义(P>0.05),治疗后NO、SOD水平升高,TXB2、ET水平降低,观察组NO、SOD水平显著高于对照组,TXB2、ET水平显著低于对照组(P<0.05); 两组治疗前N端前脑钠肽(NT-pro BNP)、白细胞介素-10(IL-10)、超敏C-反应蛋白(hs-CRP)水平比较差异无统计学意义(P>0.05),治疗后上述指标显著低于对照组(P<0.05); 观察组近期不良心血管事件发生率17.50%显著低于对照组37.50%,两组比较差异有统计学意义(P<0.05)。结论:通阳宽胸方联合PCI治疗急性心肌梗死可显著改善患者临床症状,提高治疗效果,有助于血管内皮功能的改善,降低炎性反应,药物安全性高。
Abstract:
Objective:To explore curative effect of Tongyang Kuanxiong recipe combined with PCI on acute myocardial infarction(AMI)and their influences on vascular endothelial function.Methods:A total of 80 AMI patients were enrolled as research objects.They were divided into control group and observation group according to random numbering method,40 cases in each group.The control group was treated with PCI,while observation group was treated with Tongyang Kuanxiong recipe combined with PCI.The improvement of clinical symptoms,curative effect,vascular endothelial function,levels of inflammatory factors,and occurrence of adverse cardiovascular events after treatment were compared between the two groups.Results:Before treatment,there was no significant difference in scores of TCM symptoms between the two groups(P>0.05).After treatment,scores of TCM symptoms such as chest congestion and fatigue,palpitation and shortness of breath,spitting sputum,heavy heads such as wraps and dizziness in observation group were significantly lower than those in control group(P<0.05).The response rate of treatment in observation group was significantly higher than that in control group(95.00% vs 77.50%)(P<0.05).Before treatment,there were no significant differences in levels of nitric oxide(NO),superoxide dismutase(SOD),thromboxane(TXB2)and endothelin(ET)between the two groups(P>0.05).After treatment,levels of NO and SOD were increased,while levels of TXB2 and ET were decreased.The levels of NO and SOD in observation group were significantly higher than those in control group,while levels of TXB2 and ET were significantly lower than those in control group(P<0.05).Before treatment,there were no significant differences in levels of N-terminal pro brain natriuretic peptide(NT-pro BNP),interleukin-10(IL-10)and high-sensitivity C-reactive protein(hs-CRP)between the two groups(P>0.05).After treatment,the above indexes in observation group were significantly lower than those in control group(P<0.05).The incidence of short-term adverse cardiovascular events in observation group was significantly lower than that in control group(17.50% vs 37.50%)(P<0.05).Conclusion:Tongyang Kuanxiong recipe combined with PCI in treatment of AMI can significantly improve clinical symptoms of patients,and improve curative effect,which is conducive to improvement of vascular endothelial function,and reducing inflammatory reactions,with high drug safety.

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备注/Memo

备注/Memo:
*广东省中医药局科研项目(20181216)
更新日期/Last Update: 2020-07-09