[1]林燕林,张星星,高志凌,等.清热化痰法联合亚胺培南-西司他丁钠对重症肺部感染患者IL-6、TNF-α水平的影响*[J].陕西中医,2020,(7):891-893.[doi:DOI:10.3969/j.issn.10007369.2020.07.015]
　LIN Yanlin,ZHANG Xingxing,GAO Zhiling,et al.Effect of clearing heat and removing phlegm combined with imipenem-cilastatin sodium on the levels of IL-6,TNF-α in patients with severe pulmonary infection[J].,2020,(7):891-893.[doi:DOI:10.3969/j.issn.10007369.2020.07.015]
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清热化痰法联合亚胺培南-西司他丁钠对重症肺部感染患者IL-6、TNF-α水平的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年7期
页码:
891-893
栏目:
临床研究
出版日期:
2020-07-05

文章信息/Info

Title:
Effect of clearing heat and removing phlegm combined with imipenem-cilastatin sodium on the levels of IL-6,TNF-α in patients with severe pulmonary infection
作者:
林燕林; 张星星; 高志凌; 徐桂琴
安徽中医药大学第一附属医院(合肥 230031)
Author(s):
LIN Yanlin;  ZHANG Xingxing;  GAO Zhiling; et al.
The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine(Hefei 230031)
关键词:
重症;  肺部感染;  清热化痰法;  亚胺培南-西司他丁钠;  白介素-6;  肿瘤坏死因子-α
Keywords:
Severe;  Pulmonary infection;  Clearing heat and reducing phlegm;  Imipenem-cilastatin sodium;  Interleukin-6;  Tumor necrosis factor-α
分类号:
R563
DOI:
DOI:10.3969/j.issn.10007369.2020.07.015
文献标志码:
A
摘要:
目的:探讨清热化痰法联合亚胺培南-西司他丁钠对重症肺部感染患者IL-6、TNF-α水平的影响。方法:选取80例重症肺部感染患者,采用随机数字表法将其分为对照组和观察组各40例,对照组给予亚胺培南-西司他丁钠静脉滴注治疗,观察组在此基础上加用清热化痰方鼻饲治疗,两组均连续治疗1周。对比分析两组治疗后的临床疗效及不良反应发生率; 分析两组治疗前后血清WBC计数、炎症因子水平。结果:观察组治疗总有效率为95.00%,高于对照组的90.00%(P<0.05)。与治疗前比,治疗1周后,两组血清WBC、IL-6、TNF-α水平均下降,且观察组低于对照组(P<0.05)。治疗1周后,两组APACHE Ⅱ评分均降低,且观察组低于对照组(P<0.05)。结论:中医清热化痰法联合亚胺培南-西司他丁钠治疗重症肺部感染,能显著降低患者IL-6、TNF-α水平,减轻炎症,并能降低APACHE评分,提高疗效,具有较高安全性。
Abstract:
Objective:To investigate the effect of clearing heat and removing phlegm combined with imipenem-cilastatin sodium on the levels of IL-6,TNF-α in patients with severe pulmonary infection.Methods:A total of 80 patients with severe pneumonia were divided into a control group(n=40)and an observation group(n=40)by random number table method.Imipenem-cilastatin sodium injection treatment,the observation group on this basis plus Qingre Huatan decoction oral treatment,both groups of continuous treatment for 2 weeks.The clinical efficacy and the incidence of adverse reactions in the two groups after treatment were compared; The levels of serum WBC counts,inflammatory factors before and after in the two groups of treatment were compared.Results:The total effective rate of treatment in the observation group was 95.00%,higher than 90.00% in the control group(P<0.05).Compared with before treatment,the serum levels of WBC,IL-6,TNF-α in the two groups after 2 weeks of treatment decreased,and the observation group were lower than those in the control group(P<0.05).After 2 weeks of treatment,the score of APACHE Ⅱin both groups decreased,and the observation group was lower than the control group(P<0.05).Conclusion:Traditional Chinese medicine for clearing heat and resolving phlegm combined with imipenem-cilastatin sodium in the treatment of severe pulmonary infections can significantly reduce the levels of IL-6 and TNF-α in patients,reduce inflammation,and can reduce the APACHE score,improve the efficacy,and have a higher effect.

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备注/Memo

备注/Memo:
*国家自然科学基金青年科学基金资助项目(81804030)
更新日期/Last Update: 2020-07-09