[1]李幼萍,肖忠英,倪 卫.黄芪保心汤联合比索洛尔治疗射血分数保留型心力衰竭疗效及对患者心功能的影响*[J].陕西中医,2020,(10):1399-1402.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.016]
　LI Youping,XIAO Zhongying,NI Wei..Clinical efficacy of Huangqi Baoxin decoction combined with bisoprolol in the treatment of heart failure with preserved ejection fraction and its effects on cardiac function and 6MWT[J].,2020,(10):1399-1402.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.016]
点击复制

黄芪保心汤联合比索洛尔治疗射血分数保留型心力衰竭疗效及对患者心功能的影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年10期
页码:
1399-1402
栏目:
临床研究
出版日期:
2020-10-05

文章信息/Info

Title:
Clinical efficacy of Huangqi Baoxin decoction combined with bisoprolol in the treatment of heart failure with preserved ejection fraction and its effects on cardiac function and 6MWT
作者:
李幼萍; 肖忠英; 倪 卫
四川省内江市第一人民医院(内江 641000)
Author(s):
LI Youping; XIAO Zhongying; NI Wei.
Neijiang City First People's Hospital in Sichuan Province(Neijiang 641000)
关键词:
黄芪保心汤;  比索洛尔;  射血分数保留型心衰;  心功能;  6 min步行试验;  B型尿钠肽
Keywords:
Huangqi Baoxin decoction;  Bisoprolol;  Heart failure with preserved ejection fraction;  Cardiac function;  6min walking test;  Brain natriuretic peptide
分类号:
R541.6
DOI:
DOI:10.3969/j.issn.1000-7369.2020.10.016
文献标志码:
A
摘要:
目的:探究黄芪保心汤联合比索洛尔治疗射血分数保留型心衰(HFPEF)临床疗效及对心功能、6 min步行试验(6MWT)的影响。方法:采用随机数字表法将80例HFPEF患者随机分为观察组、对照组各40例,两组均予以血管紧张素转化酶抑制剂、利尿剂等基础治疗,对照组患者予以比索洛尔片口服,观察组患者在此基础上加服黄芪保心汤。比较两组患者治疗3个月后临床疗效,以及治疗前、治疗3个月后运动耐力(6MWT)、心功能指标[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室舒张末期容积(LVEDV)、舒张晚期血流峰速率(A)、舒张早期血流峰速率(E)]、血清生化指标[B型尿钠肽(BNP)、C反应蛋白(CRP)、半乳糖凝集素-3(Gal-3)、可溶性ST2(aST2)]水平变化。结果:治疗3个月后,观察组患者治疗总有效率明显高于对照组,差异有统计学意义(P<0.05); 两组患者6MWT均较治疗前增加,且观察组高于对照组,差异有统计学意义(P<0.05); 两组患者LVEF、LVEDV、E均较治疗前升高,且观察组高于对照组,LVEDD、LVESD、A均较治疗前降低,且观察组低于对照组,差异均有统计学意义(P<0.05); 两组患者血清BNP、CRP、Gal-3、aST2水平均较治疗前明显降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:黄芪保心汤联合比索洛尔治疗HFPEF可增强疗效,改善心功能,于患者预后有利。
Abstract:
Objective:To investigate the clinical efficacy of Huangqi Baoxin decoction combined with bisoprolol in the treatment of heart failure with preserved ejection fraction(HFPEF)and its effects on cardiac function and 6min walking test(6MWT).Methods:According to the random number table method,80 patients with heart failure with preserved ejection fraction were randomly divided into observation group and control group,with 40 cases in each group.The two groups were given basic treatments of angiotensin converting anzyme inhibitiors and diuretics,and patients in control group were given bisoprolol tablets orally while the patients in observation group were given Huangqi Baoxin decoction on this basis.The clinical efficacy after 3 months of treatment,as well as exercise tolerance(6MWT),cardiac function indexes [left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic volume(LVEDV),late diastolic blood flow peak rate(A),early diastolic blood flow peak rate(E)] and serum biochemical indexes [brain natriuretic peptide(BNP),C-reactive protein(CRP),Galectin-3(Gal-3),soluble ST2(aST2)] before treatment and after 3 months of treatment.Results:After 3 months of treatment,the total effective rate of treatment in observation group was significantly higher than those in control group(P<0.05).The 6MWT in the two groups was increased compared with that before treatment,and the index in observation group was higher than that in control group(all P<0.05).The LVEF,LVEDV and E in the two groups were increased compared with those before treatment,and the indexes in observation group were higher than those in control group,and the LVEDD,LVESD and A were decreased compared with those before treatment,and the indexes in observation group were lower than those in control group(all P<0.05).The serum levels of BNP,CRP,Gal-3 and aST2 in the two groups were significantly decreased compared with those before treatment,and the levels in observation group were lower than those in control group(all P<0.05).Conclusion:Huangqi Baoxin decoction combined with bisoprolol for HFPEF can enhance the efficacy and improve cardiac function,and it is also helpful for prognosis.

参考文献/References:

[1] 甄宇治,邓彦东,李立卓,等.比索洛尔对左心室射血分数保留的心力衰竭患者神经内分泌因子的影响[J].中国临床药理学杂志,2015,12(15):1471-1474.
[2] 甄宇治.比索洛尔联合曲美他嗪治疗左心室射血分数保留的心力衰竭的临床研究[J].中国临床药理学杂志,2016,32(19):1735-1737.
[3] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):3-10.
[4] 蔡 琳.《2007 ESC心力衰竭和超声协会对诊断左室射血分数正常心力衰竭的共识》如何诊断舒张性心力衰竭[J].心血管病学进展,2008,29(1):17-20.
[5] 刘 玥,齐 新,贾文军,等.慢性心力衰竭患者血清和肽素水平与中医分型的相关性研究[J].天津中医药,2016,33(10):592-595.
[6] 李伟刚,刘素阁,齐亚娟,等.阿托伐他汀对射血分数保留慢性心衰患者心室重构及CHl3L1和MMP-9水平的影响[J].中国慢性病预防与控制,2017,25(12):54-57.
[7] Katy E,Chad H,Susanne H,et al.Validity of the six minute walk test in facioscapulohumeral muscular dystrophy:6MWT in FSHD[J].Muscle & Nerve,2016,55(3):333.
[8] 罗剑锋,严 激,徐 健,等.不同左室射血分数的心力衰竭患者临床特征比较[J].安徽医学,2018,14(6):728-730.
[9] Adams V,Alves M,Fischer T,et al.High intensity interval training attenuates endothelial dysfunction in a Dahl salt-sensitive rat model of heart failure with preserved ejection fraction(HFPEF)[J].Journal of Applied Physiology,2015,119(6):1123-1125.
[10] 陈 婵,张 鹏,王 娟,等.射血分数保留和射血分数减低心力衰竭中医四诊及证候特征研究[J].中西医结合心脑血管病杂志,2019,9(7):972-975.
[11] 李红文,关安平,柳莎莎.注射用益气复脉配合西药对难治性终末期心衰患者的疗效观察[J].陕西中医,2016,37(8):989-990.
[12] 杜 蕊,陈 民,李文杰.倍他乐克联合温阳益气化瘀利水法治疗慢性心力衰竭临床观察[J].中国中医急症,2016,25(6):1212-1214.
[13] 张 茂,刘四荣.温阳健脾法对老年慢性心力衰竭病人血清BNP、MMP2及肝细胞生长因子水平的影响[J].中西医结合心脑血管病杂志,2016,14(16):1848-1851.
[14] 丁 鹏,李春娟.β受体阻滞剂联合他汀类药物治疗慢性心衰临床观察[J].陕西医学杂志,2017,46(2):264-265.
[15] 施 冰,张 健,尹秋生,等.半乳糖凝集素3在心肌梗死后心力衰竭患者中的表达水平[J].中国循证心血管医学杂志,2015,31(1):41-42.
[16] 张志强,朱云霞,崔晓敬,等.急性冠脉综合征患者血浆NT-pro BNP和P选择素水平变化及意义[J].中国急救复苏与灾害医学杂志,2019,14(10):945-948.
[17] 张 勇,石 爽,殷艳蓉.血清IL-17、超敏C反应蛋白与冠心病冠脉病变程度关系研究[J].陕西医学杂志,2018,47(9):1141-1142.

相似文献/References:

[1]朱舜明,张学军,张荣怀,等.生脉注射液联合靶剂量比索洛尔对高血压伴心力衰竭患者血管内皮功能和心功能的影响*[J].陕西中医,2020,(10):1403.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.017]
　ZHU Shunming,ZHANG Xuejun,ZHANG Ronghuai,et al.Effects of Shengmai injection combined with target dose bisoprolol on vascular endothelial function and cardiac function in patients with hypertension and heart failure[J].,2020,(10):1403.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.017]

备注/Memo

备注/Memo:
*四川省内江市科技支撑计划项目(201750)
更新日期/Last Update: 2020-10-10