[1]刘 涛,吴显文,杨太峰.葛根芩连汤加减内服联合保留灌肠治疗放射性直肠炎疗效研究*[J].陕西中医,2020,(10):1422-1425.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.022]
　LIU Tao,WU Xianwen,YANG Taifeng..Study on the curative efficacy of Gegen Qinlian decoction addition and subtraction oral administration combined with retention enema in the treatment of radiation proctitis[J].,2020,(10):1422-1425.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.022]
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葛根芩连汤加减内服联合保留灌肠治疗放射性直肠炎疗效研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年10期
页码:
1422-1425
栏目:
临床研究
出版日期:
2020-10-05

文章信息/Info

Title:
Study on the curative efficacy of Gegen Qinlian decoction addition and subtraction oral administration combined with retention enema in the treatment of radiation proctitis
作者:
刘 涛; 吴显文; 杨太峰
中国中医科学院西苑医院肿瘤科(北京 100091)
Author(s):
LIU Tao; WU Xianwen; YANG Taifeng.
Department of Oncology,Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine(Beijing 100091)
关键词:
放射性直肠炎;  保留灌肠;  葛根芩连汤加减;  证候积分;  C反应蛋白;  不良反应
Keywords:
Radiation proctitis;  Retention enema;  Gegen Qinlian decoction addition and subtraction;  Syndrome score;  C-reactive protein;  Adverse reactions
分类号:
R516.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.10.022
文献标志码:
A
摘要:
目的:探讨葛根芩连汤加减内服联合保留灌肠治疗放射性直肠炎的疗效,为临床治疗提供参考依据。方法:将80例放射性直肠炎患者采用随机数表法分为观察组和对照组各40例。对照组使用蒙脱石散、地塞米松保留灌肠治疗,观察组使用葛根芩连汤加减内服联合保留灌肠治疗,均连续治疗7 d。比较两组治疗后临床疗效、治疗前与治疗后7 d的中医证候积分、放射治疗后反应评分标准(RTOG/EORTC)分级及炎症指标C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平变化,并观察治疗期间不良反应。结果:治疗后7 d,观察组治疗的总有效率为95.00%,明显高于对照组的80.00%(P<0.05); 观察组大便脓血、里急后重、肛门灼热、腹痛的中医证候积分均明显低于对照组(P<0.05); 观察组RTOG/EORTC分级明显优于对照组(P<0.05); 观察组CRP、TNF-α、IL-6、PCT水平均明显低于对照组(P<0.05); 两组均无明显不良反应发生(P>0.05)。结论:葛根芩连汤加减内服联合保留灌肠治疗放射性直肠炎疗效显著,可有效改善中医证候积分、缓解炎症状态,促进疾病恢复,安全性好。
Abstract:
Objective:To study the curative efficacy of Gegen Qinlian decoction addition and subtraction oral administration combined with retention enema in the treatment of radiation proctitis,to provide reference for clinical treatment.Methods:80 cases patients of radiation proctitis were selected as research objects,they were divided into the observation group and the control group by the random number table,40 cases each.The control group was treated with montmorillonite powder and dexamethasone retention enema,while the observation group was treated with Gegen Qinlian decoction addition and subtraction oral administration combined with retention enema,they were continuous treatment 7d.The after treatment clinical effect,the changes of the TCM syndrome score,post radiotherapy response score(RTOG/EORTC)grade,inflammation index C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)before and after treatment 7 days in two groups were compared,and the adverse reactions were observed during the treatment.Results:After treatment 7 days,the total effective rate of the observation group was 95.00%,which was significantly higher than the control group's 80.00%(P<0.05); the TCM syndrome scores of the bloody stools,severe internal emergency,hot anus,abdominal pain in the observation group were significantly lower than that of the control group(P<0.05); the RTOG/EORTC classification in the observation group was significantly better than that in the control group(P<0.05); the expression of CRP,TNF-α,IL-6 and PCT in the observation group were significantly lower than those in the control group(P<0.05); there was no significant adverse reactions in two groups(P>0.05).Conclusion:Gegen Qinlian decoction addition and subtraction oral administration combined with retention enema is well for retention enema,which can effectively improve the TCM syndrome score,alleviate the inflammatory state,promote the disease recovery,and has good safety,which is worthy of application and promotion.

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备注/Memo

备注/Memo:
*中国中医科学院第三批中医优势病种项目(CACMS08Y0030)
更新日期/Last Update: 2020-10-10