[1]刘佳钰,栗 程,李映雪△,等.尪痹胶囊治疗老年类风湿关节炎疗效研究*[J].陕西中医,2020,(10):1443-1445.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.028]
　LIU Jiayu,LI Cheng,LI Yingxue,et al.Wangbi capsule in the treatment of elderly patients with rheumatoid arthritis[J].,2020,(10):1443-1445.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.028]
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尪痹胶囊治疗老年类风湿关节炎疗效研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年10期
页码:
1443-1445
栏目:
临床研究
出版日期:
2020-10-05

文章信息/Info

Title:
Wangbi capsule in the treatment of elderly patients with rheumatoid arthritis
作者:
刘佳钰1; 栗 程2; 李映雪1△; 刘 丹1; 吕艳艳1; 刘 焕1; 杨 洋3(美国); 史雅锋1
1.西安市第五医院(西安 710082); 2.西安市中心医院老年病科(西安 710048); 3.美国费城爱因斯坦医学中心(宾夕法尼亚州 19141)
Author(s):
LIU Jiayu; LI Cheng; LI Yingxue; et al.
Xi'an No.5 Hospital(Xi'an 710082)
关键词:
老年类风湿关节炎;  尪痹胶囊;  白介素-17;  白介素-10;  红细胞沉降率;  C反应蛋白
Keywords:
Elderly rheumatoid arthritis;  Wangbi capsule;  Erythrocyte sedimentation rate;  Interleukin-10;  Erythrocyte sedimentation rate;  C-reactive protein
分类号:
R593.22
DOI:
DOI:10.3969/j.issn.1000-7369.2020.10.028
文献标志码:
A
摘要:
目的:探讨尪痹胶囊在老年类风湿关节炎(RA)患者中的临床疗效。方法:回顾性分析128例老年RA患者的临床资料,根据治疗方式不同分为研究组(67例)与对照组(61例),研究组采用尪痹胶囊联合来氟米特治疗,对照组采用来氟米特治疗,比较两组DAS28评分、红细胞沉降率(ESR)、C反应蛋白(CRP),白细胞介素-17(IL-17)、白细胞介素-10(IL-10)、疼痛评分、功能改善效果。结果:治疗后,研究组DAS28评分、VAS评分、ESR、CRP、IL-17水平均低于对照组,改善效果优于对照组,差异有统计学意义(P<0.05)。而治疗后,研究组IL-10水平明显高于对照组(P<0.05)。结论:对RA患者采用尪痹胶囊治疗,可有效改善其临床症状,利于缓解疼痛程度,以及降低免疫炎症反应作用。
Abstract:
Objective:To investigate the clinical effect of Wangbi capsule in the treatment of elderly patients with rheumatoid arthritis(RA).Methods:The clinical data of 128 elderly patients with RA were retrospectively analyzed.According to the different treatment methods,they were divided into study group(67 cases)and control group(61 cases).The study group was treated with Wangbi capsule combined with leflunomide,and the control group was treated with leflunomide.The DAS28 score,Erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),Interleukin-17(IL-17),Interleukin-10(IL-10),pain score and functional improvement score of the two groups were evaluated.Results:After treatment,the levels of DAS28,VAS,ESR,CRP and IL-17 in the study group were lower than those in the control group,and the effect of functional improvement was better than that in the control group,with statistical significance(P<0.05).After treatment,the level of IL-10 in the study group was significantly higher than that in the control group(P<0.05).Conclusion:The treatment of RA patients with Wangbi capsule can effectively improve their clinical symptoms,relieve pain and reduce the role of immune inflammation.

参考文献/References:

[1] 盛苏红.老年类风湿关节炎的发病特点及辨证分型的临床观察[D].南京:南京中医药大学,2019.
[2] Singh JA,Saag KG,Bridges SLJR,et al.2015 American college of rheumatology guideline for the treatment of rheumatoid arthritis[J].Arthritis Care Res(Hoboken),2016,68(1):1-25.
[3] Smolen JS,Landewe R.EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs:2016 update [J].Ann Rheum Dis,2017,76(6):960-977.
[4] 中华医学会风湿病学分会.2018中国类风湿关节炎诊疗指南[J].中华内科杂志,2018,57(4):242-251.
[5] 尚 磊,李映雪.补肾通痹汤联合雷公藤多苷治疗老年类风湿关节炎疗效研究[J].陕西中医,2019,40(11):1552.
[6] Aletaha D,Neogi T,Silman AJ,et al.2010 Rheumatoid arthritis classification criteria:an American college of rheumatology/European league against rheumatism collaborative initiative[J].Arthritis & Rheumatism,2010,62(9):2569-2581.
[7] 刘 丹,张 杰,陈庆平,等.类风湿关节炎自身免疫抗体谱的临床应用和研究进展[J].中国地方病防治杂志,2015,30(2):102-103.
[8] 倪丹红,刘 丹,吕琴琴,等.秦息痛片联合传统抗风湿药治疗早期活动性类风湿关节炎临床研究[J].陕西中医,2019,40(4):484-486.
[9] 朱洁宜,吴鑫宇,周海纯,等.中医药治疗类风湿关节炎的研究进展[J].中医药信息,2015,32(1):115-117.
[10] 陈庆平,史雅峰,沈斯瑶,等.类风湿关节炎实验室诊断指标与DAS28评分相关性的研究[J].陕西医学杂志,2012,41(11):1469-1470.
[11] 刘冬梅,杨丽丽,薛红霞.尪痹片治疗膝骨关节炎的疗效[J].实用药物与临床,2012,26(6):66-67.
[12] 李异龙,刘满仓,许小真.尪痹片对膝骨关节炎临床症状及血清炎症因子水平的影响[J].中外医学研究,2017,15(26):22-24.
[13] 佟 丽,陈育尧,辛增辉,等.尪痹片对大鼠佐剂性关节炎踝关节组织病理损伤的抑制作用[J].中药新药与临床药理,2010,21(6):602-605.
[14] 李应霞,周亚红,胡春蓉.尪痹片对胶原诱导性关节炎大鼠白细胞介素-17和基质金属蛋白酶-10的影响[J].中国药物与临床,2016,16(5):654-656.
[15] 武树朋.血清GM-CSF、TNF-α及IL-17在类风湿关节炎中的表达及相关性[J].中国老年学杂志,2017,37(12):3041-3042.
[16] 姜小帆,李娟娥,衣 蕾,等.辨证论治配合西药治疗类风湿性关节炎45例[J].陕西中医,2014,35(5):545-547.

备注/Memo

备注/Memo:
*陕西省自然科学基础研究计划项目(2016JM8147)；西安市中医药管理局项目(2018ZY0201)；西安市科技计划项目[20YXYJ0003(7)]
更新日期/Last Update: 2020-10-10