[1]徐丽娟,宫安明,马剑海.祛疡清热汤治疗中重度溃疡性结肠炎疗效及对患者血清LPO与SCD-1表达的影响*[J].陕西中医,2020,(11):1552-1555.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.009]
　XU Lijuan,GONG Anming,MA Jianhai..Effect of Quyang Qingre decoction on the expression of serum LPO and SCD-1 in patients with moderate to severe ulcerative colitis[J].,2020,(11):1552-1555.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.009]
点击复制

祛疡清热汤治疗中重度溃疡性结肠炎疗效及对患者血清LPO与SCD-1表达的影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年11期
页码:
1552-1555
栏目:
临床研究
出版日期:
2020-11-05

文章信息/Info

Title:
Effect of Quyang Qingre decoction on the expression of serum LPO and SCD-1 in patients with moderate to severe ulcerative colitis
作者:
徐丽娟; 宫安明; 马剑海
河北省秦皇岛市中医医院肛肠科(秦皇岛 066002)
Author(s):
XU Lijuan; GONG Anming; MA Jianhai.
Department of Anorectal Medicine,Qinhuangdao Traditional Chinese Medicine Hospital(Qinhuangdao 066002)
关键词:
中重度溃疡性结肠炎;  祛疡清热汤;  英夫利昔单抗;  脂质过氧化物;  硬脂酰辅酶A脱氢酶
Keywords:
Moderate to severe ulcerative colitis;  Quyang Qingre decoction;  Infliximab;  LPO;  SCD-1
分类号:
R516.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.11.009
文献标志码:
A
摘要:
目的:探讨祛疡清热汤对中重度溃疡性结肠炎患者血清中脂质过氧化物(LPO)与硬脂酰辅酶A脱氢酶(SCD-1)表达的影响。方法: 将84例中重度溃疡性结肠炎患者作为研究对象,依照随机数字表法将患者分为观察组和对照组,每组42例。对照组给予英夫利昔单抗治疗,观察组在对照组的基础上加用祛疡清热汤治疗,对比两组患者的临床疗效及不良反应的发生情况,以及在治疗前后T细胞群、LPO及硬脂酰-LPC/油酰-LPC(SCD-1)水平的变化情况。结果:经治疗结束后,两组患者均有一定疗效(观察组90.5% 与对照组73.8%,χ2=3.977,P<0.05),且不良反应发生率较低; 经治疗结束后,两组的Treg/Th17相较于治疗前明显升高,且观察组的Treg/Th17显著高于对照组,差异具有统计学意义(P<0.05); 经治疗结束后,两组患者血清中LPO明显下降,硬脂酰-LPC/油酰-LPC得到升高,且观察组的LPO与硬脂酰-LPC/油酰-LPC水平显著优于对照组,差异有统计学意义(P<0.05)。结论:采用祛疡清热汤治疗中重度溃疡性结肠炎具有较好的临床疗效,可调节血清LPO与SCD-1的表达水平,增强免疫功能。
Abstract:
Objective:To investigate the effect of Quyang Qingre decoction on the expression of LPO and SCD-1 in the serum of patients with moderate to severe ulcerative colitis.Methods:84 patients with moderate to severe ulcerative colitis were studied.The patients were divided into observation group and control group according to random number table method,42 cases in each group.The control group was treated with infliximab,and the observation group was treated with Quyang Qingre decoction on the basis of the control group.The clinical efficacy and the occurrence of adverse reactions,as well as the T cell population and LPO before and after treatment were compared between the two groups.And the change of stearoyl-LPC/oleoyl-LPC(SCD-1)levels.Results:After the treatment,both groups of patients had a certain effect(90.5% of the observation group vs 73.8% of the control group,χ2=3.977,P<0.05),and the incidence of adverse reactions was low; after the treatment,the Tregs of the two groups Th17 was significantly higher than before treatment,and the Treg/Th17 of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05); after treatment,the serum LPO of the two groups of patients decreased significantly,hard Fatty acyl-LPC/oleoyl-LPC was elevated,and the LPO and stearoyl-LPC/oleoyl-LPC levels of the observation group were significantly better than the control group,reaching a statistical difference(P<0.05).Conclusion:The use of Quyang Qingre decoction has a good clinical effect on the treatment of moderate to severe ulcerative colitis.It can regulate the expression levels of serum LPO and SCD-1,enhance immune function,and is worthy of clinical promotion.

参考文献/References:

[1] Kubota KM,Uchiyama K,Azuma Y,et al.P696 The usefulness to treatment enhancement for the patients of ulcerative colitis with clinical remission diagnosed as Mayo endoscopic subscore 1[J].Journal of Crohns & Colitis,2020(14):564.
[2] Chimalakonda A,Jones J,Dockens R,et al.P349 Cyclosporine has no clinically meaningful effect on pharmacokinetics(PK)of BMS-986165,an oral selective tyrosine kinase 2(TYK2)inhibitor,in healthy subjects[J].Journal of Crohns & Colitis,2019(13):277-278.
[3] Angelidou I,Chrysanthopoulou A,Mitsios A,et al.REDD1/autophagy pathway is associated with neutrophil-driven IL-1β inflammatory response in active ulcerative colitis[J].Journal of Immunology,2018,200(12):3949-3961.
[4] 房先顺,曾 波.自拟健脾清热汤治疗溃疡性结肠炎脾虚湿热证疗效观察[J].现代中西医结合杂志,2019,28(13):55-58.
[5] 王 佳,陈爱霞,李洪超.康复新液联合双歧杆菌三联活菌胶囊对溃疡性结肠炎患者血清LPO,SOD水平及生活质量的影响[J].中国现代医学杂志,2019,29(15):82-86.
[6] 明 兰,徐 速,徐曙光,等.中医药干预对溃疡性结肠炎硬脂酰辅酶A脱氢酶1的变化观察[J].临床消化病杂志,2018,30(2):84-87.
[7] 中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见(2018年?北京)[J].中国实用内科杂志,2018,38(9):796-813.
[8] 陈治水,危北海,张万岱,等.溃疡性结肠炎中西医结合诊疗指南 [J].中国中西医结合消化杂志,2011,19(1):61-65.
[9] 郝永彪,张晓燕.祛疡清热汤治疗湿热蕴结型溃疡性结肠炎的临床疗效观察及对Treg/Th17的调节作用研究[J].四川中医,2018,36(6):114-117.
[10] 明 兰,徐 速,徐曙光,等.中医药干预对溃疡性结肠炎硬脂酰辅酶A脱氢酶1的变化观察[J].临床消化病杂志,2018,30(2):84-87.
[11] 杨 俊,金 玉,潘 迪,等.英夫利昔单抗治疗溃疡性结肠炎的效果及对炎症因子水平的影响[J].中国医药导报,2017,14(15):148-151.
[12] Subramanian S,Rainbow L,Gemmell M,et al.OWE-37 CD4 T-cell HLA-U pseudogene at baseline predicts clinical remission to anti-TNF agents in ulcerative colitis[J].Gut,2019,68(2):64-65.
[13] Lim J,Hammami MB,Mahadevan U.Infliximab use in a child with ulcerative colitis and prior in utero exposure to infliximab[J].Gastroenterology,2020,158(6):1834-1835.
[14] 张 涛,马媛萍,黄晓燕,等.健脾清热活血方干预PI3K-Akt/mTOR信号通路调控CDK1表达防治溃疡性结肠炎相关癌变[J].辽宁中医杂志,2017,44(6):1124-1128.
[15] 陈伦虎,宋方敏,李和平,等.高迁移率族蛋白B1在溃疡性结肠炎组织中的表达及其与氧化应激、屏障功能损伤的相关性研究[J].现代消化及介入诊疗,2019,24(10):1104-1108.

备注/Memo

备注/Memo:
*河北省秦皇岛市科学技术局项目(201703A047)
更新日期/Last Update: 2020-11-09