[1]周 琼,毛跃如,皮阿琼,等.崩证固冲汤联合米非司酮治疗围绝经期功能失调性子宫出血临床研究*[J].陕西中医,2020,(11):1587-1590.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.019]
　ZHOU Qiong,MAO Yueru,PI Eqiong,et al.Clinical study on the treatment of perimenopausal dysfunctional uterine bleeding with Bengzheng Guchong decoction combined with mifepristone tablets[J].,2020,(11):1587-1590.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.019]
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崩证固冲汤联合米非司酮治疗围绝经期功能失调性子宫出血临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年11期
页码:
1587-1590
栏目:
临床研究
出版日期:
2020-11-05

文章信息/Info

Title:
Clinical study on the treatment of perimenopausal dysfunctional uterine bleeding with Bengzheng Guchong decoction combined with mifepristone tablets
作者:
周 琼1; 毛跃如1; 皮阿琼1 ;  王国经2
1.广州中医药大学(广州 510006); 2.解放军火箭军特色医学中心肝胆外科(北京 100088)
Author(s):
ZHOU Qiong; MAO Yueru; PI Eqiong; et al.
Guangzhou University of Chinese Medicine(Guangzhou 510006)
关键词:
崩证固冲汤;  米非司酮片;  围绝经期功能失调性子宫出血;  子宫内膜厚度;  激素水平
Keywords:
Bengzheng Guchong decoction;  Mifepristone tablets;  Perimenopausal dysfunctional uterine bleeding;  Endometrial thickness;  Hormone levels
分类号:
R711.52
DOI:
DOI:10.3969/j.issn.1000-7369.2020.11.019
文献标志码:
A
摘要:
目的:探讨崩证固冲汤联合米非司酮片治疗围绝经期功能失调性子宫出血临床疗效。方法:选取围绝经期功能失调性子宫出血患者98例,随机分为治疗组和对照组各49例,对照组使用米非司酮片治疗,治疗组在此基础上给予崩证固冲汤进行联合治疗,比较两组临床疗效,并观察两组出血情况、Hb水平和子宫内膜厚度、治疗前后激素水平,比较两组不良反应发生情况。结果:治疗组治疗有效率(93.88%)高于对照组(81.63%),差异有统计学意义(χ2=7.852,P<0.05)。治疗组控制出血时间和完全止血时间均少于对照组,差异有统计学意义(t=21.928、20.689,P<0.05)。治疗前两组Hb水平和子宫内膜厚度差异无统计学意义(P>0.05); 治疗后两组Hb水平均升高,子宫内膜厚度均降低,且治疗组升高/降低程度较对照组明显(P<0.05)。治疗前,两组激素水平差异无统计学意义(P>0.05); 治疗后两组FSH、LH和E2水平均降低,且治疗组患者降低程度更加明显,差异有统计学意义(P<0.05)。治疗组不良反应发生率(4.08%)明显低于对照组(16.33%),差异有统计学意义(χ2=4.009,P<0.05)。结论:崩证固冲汤联合米非司酮片治疗围绝经期功血疗效显著,可改善患者出血情况和激素水平,且不良反应较少,安全性较高。
Abstract:
Objective:Explore the clinical effect of Bengzheng Guchong decoction combined with mifepristone tablets in the treatment of perimenopausal dysfunctional uterine bleeding.Methods:Selected 98 patients with menopausal transition function,were randomly divided into treatment group(49 cases)and control group(49 cases)and control group treated with mifepristone tablets,treatment group on the basis of this and Bengzheng Guchong decoction for combination therapy.Results:The effective rate of the treatment group(93.88%)was higher than that of the control group(81.63%),the difference was statistically significant(χ2=7.852,P<0.05).The time of bleeding control and complete hemostasis in the treatment group was less than that in the control group,and the difference was statistically significant(t=21.928,20.689,P<0.05).Before treatment,there was no significant difference between the two groups in Hb level and endometrial thickness(P>0.05).After treatment,Hb level and endometrial thickness in both groups were increased,and the degree of increase/decrease in the treatment group was significantly higher than that in the control group(P<0.05).Before treatment,there was no significant difference in hormone levels between the two groups(P>0.05).After treatment,FSH,LH and E2 levels in the two groups were all decreased,and the degree of reduction was more significant in the treatment group,with statistically significant difference(P<0.05).The incidence of adverse reactions in the treatment group(4.08%)was significantly lower than that in the control group(16.33%),and the difference was statistically significant(χ2=4.009,P<0.05).Conclusion:The treatment of perimenopausal dysfunctional uterine bleeding with Bengzheng Guchong decoction combined with mifepristone tablets has a significant clinical effect,can significantly improve the patient's bleeding,improve hormone levels,and fewer adverse reactions.

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备注/Memo

备注/Memo:
*北京市科技计划项目(Z181100001718012)
更新日期/Last Update: 2020-11-09