[1]徐亚辉,才丽娜,贺大权,等.活血复健汤治疗脑卒中疗效及对患者神经功能与血清相关指标的影响*[J].陕西中医,2020,(11):1615-1618.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.026]
　XU Yahui,CAI Li'na,HE Daquan,et al.The effect of Huoxue Fujian decoction on cerebral apoplexy and its related indexes of nerve function and serum[J].,2020,(11):1615-1618.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.026]
点击复制

活血复健汤治疗脑卒中疗效及对患者神经功能与血清相关指标的影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年11期
页码:
1615-1618
栏目:
临床研究
出版日期:
2020-11-05

文章信息/Info

Title:
The effect of Huoxue Fujian decoction on cerebral apoplexy and its related indexes of nerve function and serum
作者:
徐亚辉; 才丽娜; 贺大权; 杨大为; 王培福
航天中心医院神经内科(北京 100049)
Author(s):
XU Yahui; CAI Li'na; HE Daquan; et al.
Department of Neurology,Aerospace Central Hospital(Beijing 100049)
关键词:
缺血性脑卒中;  活血复健汤;  神经功能;  超敏C反应蛋白;  基质金属蛋白酶-9;  一氧化氮
Keywords:
Ischemic stroke;  Huoxue Fujian decoction;  Neurological function;  Hypersensitive C-reactive protein; Matrix metalloproteinase-9;  Nitric oxide
分类号:
R743.33
DOI:
DOI:10.3969/j.issn.1000-7369.2020.11.026
文献标志码:
A
摘要:
目的:研究活血复健汤对于脑卒中患者神经功能与血清相关指标的影响。方法:选取98例急性缺血性脑卒中患者纳入本次研究,将入选患者按随机数字表法均分为对照组与治疗组,对照组给予常规西药治疗,治疗组在对照组的基础上给予自拟活血复健汤口服; 治疗3个月后,评估两组临床疗效,观察两组患者治疗前后神经功能缺损、生活能力、活动功能情况的变化情况,检测两组患者治疗前后血清相关指标表达水平的变化情况。结果:治疗组总有效率为97.96%,对照组为81.63%,两组比较治疗组更优(P<0.05); 治疗后,两组患者NIHSS均有下降、Barthel指数与Fugl-Meyer得分均有升高(P<0.05),且治疗组均优于对照组(P<0.05); 治疗后,两组患者血清超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、神经元特异性烯醇化酶(NSE)、中枢神经特异蛋白(S100β)、髓鞘碱性蛋白(MBP)水平均有下降,血清NO水平均有升高(P<0.05),且治疗组均优于对照组(P<0.05)。结论:活血复健汤能够提高脑卒中患者的临床疗效,进一步改善患者的神经功能,调节患者血清相关指标的表达水平。
Abstract:
Objective:To study the effect of Huoxue Fujian decoction on neurological function and serum related indexes in patients with stroke.Methods:The objects of study were 98 patients with acute ischemic stroke.The included patients were divided into the control group and the treatment group according to the random number method.After 3 months of treatment,the clinical curative effect of the two groups was evaluated; the changes of neurologic deficit,living ability and activity function of the two groups were observed before and after treatment; and the changes of serum related index expression levels were detected in the two groups before and after treatment.Results:The overall response rate was 97.96% in the treatment group and 81.63% in the control group.After treatment,NIHSS in both groups decreased,Barthel index and Fugl-Meyer score increased(P<0.05),and the treatment group was better than the control group(P<0.05).After treatment,the serum levels of hs-CRP,MMP-9,NSE,S100β and MBP in both groups decreased,and the serum level of NO increased(P<0.05),and the treatment group was superior to the control group(P<0.05).Conclusion:Huoxue Fujian decoction can improve the clinical curative effect of stroke patients,further improve the neurological function of patients and regulate the expression level of serum related indicators,which lays a solid foundation for achieving an ideal prognosis.

参考文献/References:

[1] 黄晓芸,徐安定,梅志忠,等.血清IGF-1、HCY、CRP及Aβ1～42水平与脑卒中后并发血管性认知功能障碍的关系[J].中国老年学杂志,2015,35(14):3864-3865.
[2] 李大东.补阳还五汤对急性脑梗死患者神经功能缺损及血液流变学指标的影响[J].实用中医药杂志,2017,33(4):347-348.
[3] 吴正国,王 萍.脑心通对急性脑梗死患者神经功能及VEGF、TNF-α、IL-6水平的影响[J].陕西中医,2017,38(3):280-281.
[4] 周 辉.盐酸川芎嗪联合补阳还五汤治疗急性脑梗死及对患者血液黏度及凝血因子的影响[J].中华中医药学刊,2016,34(12):3002-3004.
[5] 任彩霞,冯丙东,余永平.急性脑梗死患者血清hs-CRP、IL-6和TNF-α测定及其临床意义[J].陕西医学杂志,2016,45(11):1501-1502.
[6] 刘茂林,林大勇,白 剑.益气活血通络汤治疗急性脑梗死效果及对肢体功能障碍的影响[J].中华中医药学刊,2019,37(5):1234-1236.
[7] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[8] 李 平,吴钟璇,张云如,等.中风病诊断与疗效评定标准(试行)[J].北京中医药大学学报,1996,19(1):55-56.
[9] 张 磊.美国国立卫生研究院卒中量表[J].中华神经外科杂志,2014,30(1):79.
[10] 张明园,何燕玲.日常生活能力量表问卷与应用说明[J].上海精神医学,1995,37(7):5-6.
[11] Malouin F,Pichard L,Bonneau C,et al.Evaluating motorrecovery early after stroke:comparison of the Fugl-Meyer assessmentand the motor assessment scale[J].Arch Phys Med Rehabil,1994,75(11):1206-1212.
[12] 国家食品药品监督管理总局.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:236-237.
[13] 徐鸿婕,曾江琴,谢 谢,等.加味小陷胸汤对痰瘀阻络型急性脑梗死患者血流变、C反应蛋白和同型半胱氨酸水平的影响[J].中国老年学杂志,2018,38(3):551-553.
[14] 曾永青,陈晓霞,苏晓玉.补阳还五汤治疗急性脑梗死的疗效及对患者血清MMP-2、hs-CRP水平的影响[J].海南医学,2020,31(2):178-180.
[15] 张守菊,李德成.祛瘀化痰通络汤联合阿替普酶对急性脑梗死患者血液流变学及血清NSE、S-100β、MBP水平的影响[J].现代中西医结合杂志,2020,29(1):95-98.
[16] 程一升,程霄霄,赵元琛,等.小续命汤治疗急性脑梗死疗效及对SOD、MCP-1以及BDNF水平的影响[J].中华中医药学刊,2019,37(2):435-437.
[17] 黄贵本.脑卒中患者血清HCY、NT-proBNP及MMP-9水平变化及其与神经功能缺损程度的关系[J].中国实验诊断学,2015,19(8):1321-1323.
[18] 盖红兵,张爱芬,李晨霞,等.血浆Hcy、D-二聚体、hs-CRP水平检测在缺血性脑卒中诊治中的价值[J].临床合理用药杂志,2014,7(10):75-76.

相似文献/References:

[1]耿银龙,张伟萍,任梦诗.温阳复元方对缺血性脑卒中患者运动功能及生存质量影响研究*[J].陕西中医,2020,(2):172.
　GENG Yinlong,ZHANG Weiping,REN Mengshi..Effect of Wenyang Fuyuan decoction on motor function and quality of life in patients with ischemic stroke[J].,2020,(11):172.
[2]杨 倩,屈 云,王凤英△.脊柱推拿联合康复治疗对缺血性脑卒中患者手功能的影响*[J].陕西中医,2020,(11):1580.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.017]
　YANG Qian,QU Yun,WANG Fengying..Effect of spinal massage combined with routine rehabilitation therapy on recovery from hand dysfunction after ischemic stroke[J].,2020,(11):1580.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.017]
[3]张锡萍,张斐雪,郑书林,等.血栓通联合吡拉西坦对缺血性脑卒中患者中医证候评分、神经功能及血清NPY、Hcy水平的影响[J].陕西中医,2021,(3):326.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.014]
　ZHANG Xiping,ZHANG Feixue,ZHENG Shulin,et al.Influence of Xueshuantong combined with piracetam on TCM syndrome score neurological function and serum NPY and Hcy in patients with cerebral ischemic stroke[J].,2021,(11):326.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.014]
[4]吕鸿燕,严兴亚,李 凤,等.缺血性脑卒中患者中医证型与Crouse积分、血清同型半胱氨酸、凝血功能相关性研究[J].陕西中医,2021,(7):879.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.017]
　LYU Hongyan,YAN Xingya,LI Feng,et al.Correlation between TCM syndromes and Crouse score,serum Hcy,coagulation function in patients with ischemic stroke[J].,2021,(11):879.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.017]
[5]陈雨菡,马善波,杨 倩,等.黄芪-丹参药对治疗缺血性脑卒中研究进展[J].陕西中医,2021,(8):1142.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.038]
　CHEN Yuhan,MA Shanbo,YANG Qian,et al.Therapeutic effect of Astragali-Salvia miltiorrhiza for ischemic stroke[J].,2021,(11):1142.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.038]
[6]倪广晓,段春巧,周宏斌,等.基于BDNF-Trk B信号通路探讨和血生络方对脑缺血大鼠认知功能的影响及机制研究[J].陕西中医,2021,(11):1481.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.001]
　NI Guangxiao,DUAN Chunqiao,ZHOU Hongbin,et al.Investigated effect of Hexue Shengluo decoction on cognitive function in MCAO rats and mechanism based on BDNF-Trk B signaling pathway[J].,2021,(11):1481.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.001]
[7]王少琴,刘丽彬.子午流注纳子法结合温通针法对缺血性脑卒中患者下肢肢体功能康复及脑血流水平的影响[J].陕西中医,2022,(4):523.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.029]
　WANG Shaoqin,LIU Libin.Effects of Ziwu Liuzhu Nazi method combined with Wentong acupuncture method on lower limb function and cerebral blood flow in patients with ischemic stroke[J].,2022,(11):523.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.029]
[8]郑 勇,程 贝,陈亦辉,等.星蒌承气汤联合丁苯酞治疗缺血性脑卒中疗效及对患者氧化应激、血液流变学的影响[J].陕西中医,2023,(2):191.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.012]
　ZHENG Yong,CHENG Bei,CHEN Yihui,et al.Effect of Xinglou Chengqi decoction combined with butylphthalide on oxidative stress and hemorheology in patients with ischemic stroke[J].,2023,(11):191.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.012]
[9]王小亮,李振东,邱航健,等.耳穴贴压对脑缺血损伤大鼠干预机制研究[J].陕西中医,2023,(7):849.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.005]
　WANG Xiaoliang,LI Zhendong,QIU Hangjian,et al.Study on intervention mechanism of auricular acupoint pressing on rats with ischemic stroke[J].,2023,(11):849.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.005]
[10]迟显苏,梁 晓,魏竞竞,等.基于血浊理论从痰、瘀、毒论治缺血性脑卒中[J].陕西中医,2023,(7):917.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.021]
　CHI Xiansu,LIANG Xiao,WEI Jingjing,et al.Treatment of ischemic stroke from perspective of phlegm blood stasis and poison based on theory of turbid blood[J].,2023,(11):917.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.021]

备注/Memo

备注/Memo:
*北京市科技计划项目(Z18100001718095)
更新日期/Last Update: 2020-11-09