参考文献/References:
[1] Lim YP,Huang JD.Interplay of pregnane X receptor with other nuclear receptors on gene regulation[J].The Japanese Society for the Study of Xenobiotics,2008,23(1):122-125.
[2] He L,Zhou X,Huang N,et al.Functions of pregnane X receptor in self-detoxification[J].Amino Acids,2017,49(12):1999-2007.
[3] Shah YM,Ma X,Morimura K,et al.Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression[J].Am J Physiol Gastrointest Liver Physiol,2007,292: 1114-1122.
[4] Xavier RJ,Podolsky DK.Unravelling the pathogenesis of inflammatory bowel disease[J].Nature,2007,448(7152):1189-1195.
[5] 孙 菁,孙明军.α-硫辛酸对溃疡性结肠炎小鼠Th17相关炎症因子表达影响研究[J].陕西医学杂志,2016,45(11):1448-1451,1455.
[6] Ho GT,Aird RE,Liu B,et al.MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation[J].Mucosal Immunology,2018,11(1):15-19.
[7] Kodama S,Negishi M.Pregnane X receptor PXR activates the GADD45beta gene,eliciting the p38 MAPK signal and cell migration [J].The Journal of Biological Chemistry,2011,286(5):255-259.
[8] Dou W,Zhang JJ,Li H,et al.Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway [J].The Journal of Nutritional Biochemistry,2014,25(9):923-933.
[9] Liu MJ,Zhang GH,Zheng C,et al.Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice [J].British Journal of Pharmacology,2018,175(17):1425-1430.
[10] Ren YJ,Yue B,Ren GY,et al.Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-κB signaling pathway [J].Scientific Reports,2019,9(1):18-24.
[11] Yu ZL,Yue B,Ding LL,et al.Activation of PXR by alpinetin contributes to abrogate chemically induced inflammatory bowel disease [J].Frontiers in Pharmacology,2020(11):455-460.
[12] Zhang J,Cao LJ,Wang H,et al.Ginsenosides regulate PXR/NF-κB signaling and attenuate dextran sulfate sodium-induced colitis [J].Drug Metab Dispos,2015,43(8):1181-1190.
[13] Deuring J,Li M,Cao WL,et al.Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease [J].PLoS One,2019,14(10): 221924.
[14] Mencarelli A,Renga B,Palladino G.Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells [J].Eur J Pharmacol,2011,668(1):317-324.
[15] Kliewer SA,Moore JT,Wade L,et al.An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway[J].Cell,1998,92(1):25-30.
[16] Neal MD,Sodhi CP,Jia H,et al.2012 Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis[J].Biol Chem,2012,287(44):37296-37308.
[17] Huang KZ,Mukherjee S,Marais V,et al.Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis [J].Pediatric Research,2018,83(5):139-142.
[18] Good M,Sodhi CP,Egan CE,et al.2015 Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor [J].Mucosal Immunol,2018(8):1166-1179.
[19] Ye N,Wang H,Hong J,et al.PXR mediated protection against liver inflammation by ginkgolide A in tetrachloromethane treated mice [J].Biomol Ther(Seoul),2016,24(1):40-48.
[20] Billiar TR,Curran RD,Williams DL,et al.Liver nonparenchymal cells are stimulated to provide interleukin 6 for induction of the hepatic acute-phase response in endotoxemia but not in remote localized inflammation [J].Arch Surg,1992,127(1):31-37.
[21] Feingold KR,Schmuth M,Elias PM.The regulation of permeability barrier homeostasis[J].Invest Dermatol,2007,127(7):1574-1576.
[22] Schmuth M,Elias PM,Feingold KR.Nukleäre hormonrezeptoren:interventionsmöglichkeiten jenseits von glukokortikoiden,retinoiden und Vitamin D[J].Dtsch Dermatol Ges,2003,1(5):352-362.
[23] Dubrac S,Elentner A,Ebner S,et al.Modulation of T lymphocyte function by the pregnane X receptor [J].J Immunol,2010,184(6):2949-2957.
[24] Beyer C,Skapenko A,Distler A,et al.Activation of pregnane X receptor inhibits experimental dermal fibrosis [J].Ann Rheum Dis,2013,72(4):621-625.
[25] Wang SL,Xie XY,Lei T,et al.Statins attenuate activation of the NLRP3 inflammasome by oxidized LDL or TNF α in vascular endothelial cells through a PXR-Dependent mechanism [J].Molecular Pharmacology,2017,92(3):255-260.
[26] Zhang J.Ginsenosides regulate PXR/NF-κB signaling and attenuate dextran sulfate sodium-induced colitis [J].Drug Metab Dispos,2015,43(8):1181-1190.
[27] Gu XS,Ke S,Liu D,et al.Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents [J].The Journal of Biological Chemistry,2006,281(26):1226-1230.
[28] Coskun M,Troelsen JT,Nielsen OH.The role of CDX2 in intestinal homeostasis and inflammation [J].Biochimica Biophysica,2011,1812(3):623-630.
[29] Dou W,Mukherjee S,Li H,et al.Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis [J].PloS One,2012,7(7):521-525.
[30] Kim S,Domon DC,Wang QD,et al.PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K,PKB/Akt,and NF-κB-dependent pathway[J].Gastroenterology,2002,123(4):316-318.
[31] 杨翰林,罗川晋,吴 伟.湿热与瘀热类炎症的中医思考[J].中西医结合心脑血管病杂志,2019,17(3):464-467.
[32] Yang JH,Kim SC,Shin YS,et al.O-Methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation[J].Food and Chemical Toxicology,2013(59):362-372.
[33] Woo KJ,Jeong YJ,Inoue H,et al.Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6(NF-IL6)DNA-binding activity[J].FEBS Lett,2005,579(3):705-711.
[34] Dou W,Zhang JJ,Zhang EY,et al.Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway[J].The Journal of Pharmacology and Experimental Therapeutics,2013,345(3):423-430.
[35] 安 鹏,李星瑶,蔡子墨,等.黄芩素对肝癌细胞HepG_2放疗增敏作用的机制研究[J].陕西中医,2018,39(2):150-153.
[36] Li Y,Wang Q,Yao XM,et al.Induction of CYP3A4 and MDR1 gene expression by baicalin,baicalein,chlorogenic acid,and ginsenoside Rf through constitutive androstane receptor and pregnane X receptor-mediated pathways[J].European Journal of Pharmacology,2010,640(1):16-20.
[37] 耿东升.黄连素的抗炎与免疫调节作用[J].解放军药学学报,2000,16(6):317-320.
[38] 余爱荣,李维亮,常伟宇,等.黄连素通过PXR信号通路调控CYP3A4和P-gp的机制研究[J].中国药师,2018,21(10):1711-1715.
[39] Zhang X,Wang Y,Ma Z,et al.Tanshinone ⅡA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor[J].Drug Des Devel Ther,2015(9):6343-6362.
[40] 蔡之幸,陈 越.小檗碱联合人参皂苷Rb1对脂肪细胞炎症信号通路作用[J].陕西中医,2020,41(3):297-300.
[41] Yu C,Chai X,Yu L,et al.Identification of novel pregnane X receptor activators from traditional Chinese medicines[J].J Ethnopharmacol,2011,136(1):137-143.
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