[1]蒋春波,於佳炜,林 静,等.肾炎1号方联合西药治疗肾病综合征疗效及对患者凝血指标、免疫功能的影响*[J].陕西中医,2020,(12):1743-1746.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.016]
　JIANG Chunbo,YU Jiawei,LIN Jing,et al.Clinical efficacy of Shenyan 1 recipe combined with western medicine in treatment of nephritic syndrome and effect on coagulation and immunity[J].,2020,(12):1743-1746.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.016]
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肾炎1号方联合西药治疗肾病综合征疗效及对患者凝血指标、免疫功能的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年12期
页码:
1743-1746
栏目:
临床研究
出版日期:
2020-12-05

文章信息/Info

Title:
Clinical efficacy of Shenyan 1 recipe combined with western medicine in treatment of nephritic syndrome and effect on coagulation and immunity
作者:
蒋春波1; 於佳炜2; 林 静2; 朱云洁1; 周 岚1; 张 莉1; 金伟民1
1.南京中医药大学附属苏州市中医医院肾内科(苏州 215009); 2.复旦大学附属中山医院肾内科(上海 200323)
Author(s):
JIANG Chunbo; YU Jiawei; LIN Jing; et al.
Department of Nephrology,Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine(Suzhou 215009)
关键词:
肾病综合征;  中西医结合疗法;  肾炎1号方;  凝血指标;  免疫功能
Keywords:
Nephrotic syndrome;  Intergrated Chinese traditional and western medicine therapy;  Shenyan 1 recipe;  Coagulation index;  Immune function
分类号:
R692
DOI:
DOI:10.3969/j.issn.1000-7369.2020.12.016
文献标志码:
A
摘要:
目的:探讨肾炎1号方联合西药治疗肾病综合征临床疗效及对患者凝血指标、免疫功能的影响。方法:选取肾病综合征患者共52例,分为对照组26例、治疗组26例。两组患者均予以基础治疗,对照组在基础治疗上给予泼尼松片治疗。治疗组在对照组基础上加用肾炎1号方治疗。结果:与对照组治疗后相比,治疗组治疗24 h后Upr、CHOL、TG、Scr、Fg、D-D均下降,差异有统计学意义(P<0.05)。治疗组治疗后补体C3升高明显,与对照组比较,差异有统计学意义(P<0.05)。治疗后治疗组中医证候积分各项均低于对照组,治疗组总有效率88.46%高于对照组的76.92%,差异均有统计学意义(P<0.05)。结论:肾炎1号方联合西药治疗肾病综合征临床效果较好,能更有效地控制患者蛋白尿、升高血清白蛋白水平、降低血清胆固醇,并且能调节机体体液免疫紊乱、改善高凝状态。
Abstract:
Objective:To observe the clinical effect of Shenyan 1 recipe combined with western medicine on nephrotic syndrome(NS)and influence on coagulation index and immune function.Methods:52 patients of NS were randomly divided into two groups.26 cases in the control group received basic treatment and prednisone treatment,and 26 cases in the treatment group added with Shenyan 1 recipe.Results:After treatment,the levels of 24 h Upr,CHOL,TG,Scr,Fg,D-D in treatment group after the treatment were lower than those in the control group after treatment(P<0.05),The level of C3 was higher than that in the control group after treatment(P<0.05).After treatment,the TCM syndrome scores in the treatment group was lower than that in the control group,differences statistically significant(P<0.05),and the total effective rate of the treatment group 88.46% was higher than that of the control group 76.92%,differences statistically significant(P<0.05).Conclusion:In the treatment of nephrotic syndrome,Shenyan 1 recipe combined with western medicine can significantly reduce proteinuria,increase serum albumin level,reduce serum cholesterol,regulate the disorder of humoral immunity,improve hypercoagulability.

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备注/Memo

备注/Memo:
*国家自然科学基金青年科学基金资助项目(81704005)；江苏省青年医学重点人才项目(QNRC2016254)；姑苏卫生青年拔尖人才项目(GSWS2019063)
更新日期/Last Update: 2020-12-11