[1]朱芳红,杨伟宁,李 锋.茵陈术附汤加减治疗肝衰竭并发难治性黄疸疗效研究[J].陕西中医,2021,(3):304-307.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.008]
　ZHU Fanghong,YANG Weining,LI Feng.Study on effect of Yinchen Zhufu decoction in the treatment of liver failure complicated by refractory jaundice[J].,2021,(3):304-307.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.008]
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茵陈术附汤加减治疗肝衰竭并发难治性黄疸疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年3期
页码:
304-307
栏目:
临床研究
出版日期:
2021-03-09

文章信息/Info

Title:
Study on effect of Yinchen Zhufu decoction in the treatment of liver failure complicated by refractory jaundice
作者:
朱芳红; 杨伟宁; 李 锋
(空军军医大学西京医院中医科,陕西 西安 710032)
Author(s):
ZHU Fanghong; YANG Weining; LI Feng
(Department of Traditional Chinese Medicine,Xijing Hospital,Air Force Military Medical University,Xi'an 710032,China)
关键词:
茵陈术附汤;  肝衰竭;  黄疸;  肝功能;  病死率
Keywords:
Yinchen Zhufu decoction;  Liver failure;  Jaundice;  Liver function;  Fatality rate
分类号:
R 256.41
DOI:
DOI:10.3969/j.issn.1000-7369.2020.03.008
文献标志码:
A
摘要:
目的:观察茵陈术附汤加减治疗肝衰竭并发难治性黄疸临床疗效。方法:将收治的90例肝衰竭并发难治性黄疸患者随机分为两组。对照组45例患者采用临床常规治疗,观察组45例患者在对照组基础上加用茵陈术附汤加减治疗。治疗8周后,对比两组临床疗效、中医证候积分、肝功能指标、血清TBA、ChE、Alb指标、不良反应发生率,随访6个月,对比两组病死率。结果:观察组临床总有效率高于对照组(P<0.05)。观察组治疗后尿黄、腹胀、纳差、乏力症状积分低于对照组(均P<0.05)。观察组治疗后TBil、AST、ALT、TBA指标低于对照组(均P<0.05)。观察组治疗后血清PTA、ChE、Alb指标高于对照组(均P<0.05)。观察组病死率低于对照组(P<0.05)。观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:茵陈术附汤可有效改善肝衰竭并发难治性黄疸患者肝功能,缓解临床症状,降低病死率,且不良反应较少。
Abstract:
Objective:To analyze the effect of Yinchen Zhufu decoction in the treatment of liver failure complicated by refractory jaundice.Methods:90 patients with liver failure complicated by refractory jaundice were randomly divided into two groups.45 patients in the reference group were treated with clinical routine treatment,45 patients in the observation group were treated with Yinchen Zhufu decoction on the basis of the reference group,and both groups were treated for 8 weeks.Clinical effect,TCM syndrome score,liver function index,serum TBA,ChE,Alb of the two groups,incidence of adverse reactions were compared.The fatality rate of the two groups were compared after 6 months follow-up.Results:The total clinical effective rate of the observation group was significantly higher than that of the reference group(P<0.05).The scores of urine yellow,abdominal distention,poor appetite and asthenia symptoms in the observation group were significantly lower than those in the reference group(all P<0.05).The TBil,AST,ALT and TBA indexes in the observation group were significantly lower than those in the reference group(all P<0.05).The serum PTA,ChE and Alb indexes in the observation group were significantly higher than those in the reference group after treatment(all P<0.05).The fatality rate in the observation group was significantly lower than that in the reference group(P<0.05).The incidence of adverse reactions in the observation group was no statistical significance compared with that in the reference group(P>0.05).Conclusion:Yinchen Zhufu decoction can effectively improve the liver function of patients with liver failure complicated by refractory jaundice,alleviate clinical symptoms,reduce fatality rate,and fewer adverse reactions.

参考文献/References:

[1] 史国峰,刘兆喆,韩 涛,等.经皮肝穿刺胆道引流术后联合当飞利肝宁对梗阻性黄疸治疗的影响[J].中国临床实用医学,2018,9(3):3-5.
[2] 刘志刚,王成福.辨证治疗慢加急性肝衰竭临床研究[J].陕西中医,2016,37(11):1447-1449.
[3] 韩元利,马济庶,安 辉,等.中药联合结肠透析高位保留灌肠治疗急性黄疸型肝炎100例[J].山西医药杂志,2016,45(9):1089-1090.
[4] 杨建华,屈芙蓉,汤永全,等.茵栀黄口服液联合思美泰治疗肝硬化黄疸疗效及对患者肝功能的影响[J].陕西中医,2019,40(10):1377-1379.
[5] 刘 宝,王 华,邵 敏,等.大鼠急性肝衰竭模型自由基和细胞因子的动态变化[J].中国急救复苏与灾害医学杂志,2007,2(11):663-665.
[6] 李晓飞.中西医结合治疗急性黄疸型肝炎的临床观察与分析[J].中医临床研究,2016,8(4):107-108.
[7] 董双龙,李银彩,王 飞.经皮穴位电刺激治疗甲型急性黄疸型肝炎的临床疗效[J].临床合理用药杂志,2016,9(3):106-108.
[8] 王开霞,郑 超,朱晓骏,等.茵陈五苓散治疗胆汁淤积研究进展[J].陕西中医,2019,40(12):1822-1825.
[9] 曹 亮,邵建国,孙源源,等.EMBD与外科手术治疗恶性梗阻性黄疸患者的恢复情况及费用比较[J].南通大学学报:医学版,2016,36(4):331-333.
[10] 郭希菊,魏云华,郭维博,等.三种人工肝治疗慢加急性肝功能衰竭疗效及对患者炎症指标的影响研究[J].陕西医学杂志,2019,48(9):1167-1170.
[11] 覃晓雾,卢杰夫,田惠芳.茵陈蒿汤治疗急性黄疸型肝炎的Meta分析[J].湖南中医杂志,2016,32(7):162-164.
[12] 王莉萍,张世昌,刘永兴,等.退黄散外洗对新生儿黄疸胆红素及血清炎症因子水平的影响[J].陕西中医,2018,39(6):784-786.
[13] 何 芸,杜兰芳.大黄、赤芍对肝衰竭大鼠血清NO合成和分泌影响研究[J].陕西中医,2018,39(6):691-694.
[14] 陆长春,蔺咏梅,韩 洁,等.人工肝治疗重型肝炎肝衰竭对近期预后的影响[J].陕西医学杂志,2014,43(3):318-319.
[15] 陈秋源,钟小生,谭志健.梗阻性黄疸的中西医治疗进展[J].现代中西医结合杂志,2016,25(2):221-225.
[16] Huang J,Cheung F,Tan HY,et al.Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology[J].Mol Med Rep,2017,16(4):4583-4592.
[17] 雷金艳,贾建伟,郭丽颖,等.茵陈术附汤加减治疗肝衰竭导致的难治性黄疸临床疗效观察[J].中西医结合肝病杂志,2015,25(1):24-26.
[18] Li JY,Cao HY,Sun L,et al.Therapeutic mechanism of Yinchenhao decoction in hepatic diseases[J].World Journal Gastroenterol,2017,23(7):1125-1138.
[19] 王守光,马长林,卢 云, 等.原发性肝癌肝切除术后肝功能衰竭的相关因素分析及防治[J].陕西医学杂志,2007,36(6):691-693.
[20] 黄娇甜,卢秀兰,肖政辉, 等.不同血液净化模式治疗儿童急性肝功能衰竭的临床疗效及预后分析[J].中国小儿急救医学,2019,26(6):447-453.
[21] 毛德文,唐 农,陈月桥,等.茵陈术附汤加味治疗慢性肝衰竭阴黄证的临床研究[J].中西医结合肝病杂志,2015,25(2):74-76.
[22] 杨润华,陈 娇,高 戎,等.茵陈蒿汤治疗脓毒症相关肝损伤的临床应用研究[J].中国中西医结合急救杂志,2016,23(3):248-252.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81273622)
更新日期/Last Update: 2021-03-08