[1]陈星星,张 欣,何金品.柴芩承气汤加减辅助治疗急性胰腺炎疗效及对患者血清胃饥饿素水平的影响[J].陕西中医,2021,(4):467-469，473.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.016]
　CHEN Xingxing,ZHANG Xin,HE Jinpin.Effects of addition and subtraction of Chaiqin Chengqi decoction assisted therapy on serum Ghrelin level in patients with acute pancreatitis[J].,2021,(4):467-469，473.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.016]
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柴芩承气汤加减辅助治疗急性胰腺炎疗效及对患者血清胃饥饿素水平的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年4期
页码:
467-469，473
栏目:
临床研究
出版日期:
2021-04-05

文章信息/Info

Title:
Effects of addition and subtraction of Chaiqin Chengqi decoction assisted therapy on serum Ghrelin level in patients with acute pancreatitis
作者:
陈星星; 张 欣; 何金品
(武汉市第一医院消化内科,湖北 武汉 430022)
Author(s):
CHEN Xingxing; ZHANG Xin; HE Jinpin
(Department of Gastroenterology,Wuhan First Hospital,Wuhan 430022,China)
关键词:
柴芩承气汤加减;  急性胰腺炎;  降钙素原;  白细胞介素-6;  胃饥饿素;  炎症反应
Keywords:
Addition and subtraction of Chaiqin Chengqi decoction;  Acute pancreatitis;  Procalcitonin;  Interleukin-6;  Ghrelin;  Inflammatory response
分类号:
R 657.51
DOI:
DOI:10.3969/j.issn.1000-7369.2020.04.016
文献标志码:
A
摘要:
目的:分析柴芩承气汤加减辅助治疗急性胰腺炎疗效及对患者血清胃饥饿素(Ghrelin)水平的影响。方法:将126例急性胰腺炎患者采用随机数字表法随机分为试验组与对照组各63例,对照组予以西医常规治疗与综合护理,试验组在此基础上辅以柴芩承气汤加减治疗。比较两组患者治疗总有效率,临床症状与体征恢复时间(血淀粉酶恢复正常时间、退热时间、腹痛缓解时间、肠鸣音恢复时间、住院时间),治疗前、治疗7 d后中医证候积分与急性生理与慢性健康评分(APACHE-Ⅱ)系统评分,以及血清生化指标[白细胞介素-6(IL-6)、降钙素原(PCT)、胃饥饿素(Ghrelin)]水平。结果:试验组治疗总有效率高于对照组(P<0.05); 治疗7 d后,两组中医证候积分与APACHE-Ⅱ评分均较治疗前降低,且试验组低于对照组(P<0.05); 试验组血淀粉酶恢复正常时间、退热时间、腹痛缓解时间、肠鸣音恢复时间、住院时间均短于对照组(P<0.05); 治疗7 d后,两组血清IL-6、PCT、Ghrelin水平均较治疗前降低,且试验组低于对照组(P<0.05)。结论:柴芩承气汤加减辅助治疗急性胰腺炎可提高疗效,改善炎症反应,改善机体内环境状态,利于患者快速恢复。
Abstract:
Objective:To analyze the effects of addition and subtraction of Chaiqin Chengqi decoction assisted therapy on serum Ghrelin level in patients with acute pancreatitis.Methods:A total of 126 patients with acute pancreatitis were divided into experimental group and control group according to the random number table method,with 63 cases in each group.Control group was given routine western medicine treatment and comprehensive nursing,and experimental group was supplemented with addition and subtraction of Chaiqin Chengqi decoction on this basis.The total effective rate of treatment,recovery times of clinical symptoms and signs(blood amylase recovery time,fever clearance time,abdominal pain relief time,bowel sound recovery time,hospital stay),and TCM symptoms scores and acute physiology and chronic health evaluation(APACHE-Ⅱ)score and levels of serum biochemical indicators [Interleukin-6(IL-6),Procalcitonin(PCT),Ghrelin] before treatment and after 7 d of treatment were compared between the two groups.Results:The total effective rate of treatment in experimental group was higher than that in control group(P<0.05).After 7 d of treatment,the TCM syndromes scores and APACHE-Ⅱ score in the two groups were lower than those before treatment,and the scores in experimental group were lower than those in control group(P<0.05).The blood amylase recovery time,fever clearance time,abdominal pain relief time,bowel sound recovery time and hospital stay in experimental group were shorter than those in control group(P<0.05).After 7 d of treatment,the levels of serum IL-6,PCT and Ghrelin in the two groups were lower than those before treatment,and the levels in experimental group were lower than those in control group(P<0.05).Conclusion: Addition and subtraction of Chaiqin Chengqi decoction assisted therapy for acute pancreatitis can improve the efficacy,improve the inflammatory response,promote the internal environment of body,and facilitate the rapid recovery of patients.

参考文献/References:

[1] 赵建东.观察中医辨证四联疗法治疗急性胰腺炎的临床疗效[J].华南国防医学杂志,2016,30(7):474-475.
[2] 贾云飞,杨晋翔,贾 玉,等.急性胰腺炎的中医证候特点临床研究[J].现代中西医结合杂志,2018,14(4):343-346.
[3] 姚邴山.柴芍承气汤加味联合舒血宁对高脂血症性重症急性胰腺炎患者生化指标、血液流变及炎性细胞因子的影响[J].陕西中医,2016,37(1):56-57.
[4] 党 琳,李绍林,魏敏惠.浅议“通法”在急性胰腺炎中的应用[J].世界中西医结合杂志,2018,13(2):170-172,257.
[5] 许才明,陈海龙,张桂信,等.谈“中医七法”辨证治疗急性胰腺炎的临床运用[J].中国中西医结合急救杂志,2015,12(1):10-14.
[6] 杨 明,王春友.《急性胰腺炎诊治指南(2014)》解读[J].中华外科杂志,2015,53(1):909-911.
[7] 张声生,李慧臻.急性胰腺炎中医诊疗专家共识意见(2017)[J].中华中医药杂志,2017,33(9):4085-4088.
[8] 王兴鹏,李兆申,袁耀宗,等.中国急性胰腺炎诊治指南(2013年,上海)[J].胃肠病学,2013,29(9):656-660.
[9] 吴县斌,苏东星,潘志刚,等.BISAP、APACHE Ⅱ、Ranson评分在预测急性胰腺炎预后中价值对比分析[J].现代消化及介入诊疗,2016,21(2):294-296.
[10] 崔 东,李洪荣,雷 全,等.针灸联合参附注射液治疗重症急性胰腺炎及对患者胃肠功能恢复和预后的影响[J].陕西中医,2018,39(7):971-973.
[11] 焦 旭,卢 云.中医药治疗急性胰腺炎的临床进展[J].中国中医急症,2016,25(10):1922-1925.
[12] 沈华海,吴军霞,谢 骊.中西医综合疗法对急性胰腺炎患者血清PCT与炎性因子的影响[J].中国中医急症,2018,27(6):1074-1076.
[13] 钱正隆,田君琪,尚 东.“以通为用”在急性胰腺炎治疗中的应用[J].辽宁中医药大学学报,2016,12(4):92-95.
[14] 温 林,孟庆兰.乳果糖灌肠联合生长抑素治疗急性胰腺炎疗效及对炎性因子和肠黏膜屏障功能的影响[J].现代中西医结合杂志,2016,25(31):3476-3478.
[15] 芶 宇.重用生大黄和芒硝治疗急性胰腺炎的疗效观察[J].中国中西医结合急救杂志,2016,23(5):475-478.
[16] 刘振国,王 婷,王顺达,等.大黄芒硝对老年重症急性胰腺炎患者胃肠功能及APACHEⅡ评分的影响研究[J].陕西医学杂志,2017,46(2):153-154.
[17] 杜进龙,李玉梅,齐建华,等.中医综合方案联合西医常规治疗急性胰腺炎的临床疗效观察[J].中国中医基础医学杂志,2018,24(1):87-89.
[18] 陈滢俸,刘慧玲.柴芩承气汤治疗急性轻症胰腺炎护理效果观察[J].辽宁中医药大学学报,2017,19(10):216-218.
[19] 刘 静.红细胞分布宽度联合降钙素原检测对急性胰腺炎严重程度及预后评估价值分析[J].陕西医学杂志,2020,49(4):470-473,497.
[20] 宋亚邛,胡海燕.VEGF,TGF-β1,CA 19-9,CA242和DKK1联合检测对早期胰腺癌临床诊断价值研究[J].陕西医学杂志,2020,49(2):111-114.

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备注/Memo

备注/Memo:
基金项目:湖北省卫生科研项目(WJ2019M027)
更新日期/Last Update: 2021-04-09