[1]陈益家,唐佳佳,刘世举.八珍散加减改善结直肠癌根治术后患者胃肠功能和免疫功能临床研究[J].陕西中医,2021,(5):577-581.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.008]
　CHEN Yijia,TANG Jiajia,LIU Shiju.Bazhen powder in improving gastrointestinal function and immune function after radical resection of colorectal cancer[J].,2021,(5):577-581.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.008]
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八珍散加减改善结直肠癌根治术后患者胃肠功能和免疫功能临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年5期
页码:
577-581
栏目:
临床研究
出版日期:
2021-05-05

文章信息/Info

Title:
Bazhen powder in improving gastrointestinal function and immune function after radical resection of colorectal cancer
作者:
陈益家1; 唐佳佳1; 刘世举2
(1.绵阳市中医医院肛肠科,四川 绵阳 621000; 2.河南中医药大学第三附属医院肛肠外科,河南 郑州 450003)
Author(s):
CHEN Yijia; TANG Jiajia; LIU Shiju
(Department of Anorectal,Mianyang Hospital of Traditional Chinese Medicine,Mianyang 621000,China)
关键词:
八珍散;  直肠癌根治术;  胃肠功能;  免疫功能;  胃动素
Keywords:
Bazhen powder;  Radical resection of rectal cancer;  Gastrointestinal function;  Immune function;  Motilin
分类号:
R 735.37
DOI:
DOI:10.3969/j.issn.1000-7369.2020.05.008
文献标志码:
A
摘要:
目的:探究八珍散加减对结直肠癌根治术后胃肠功能和免疫功能的影响。方法:选择拟进行手术治疗的结直肠癌患者88例作为研究对象,根据随机抽签原则分为对照组(采用常规手术方法进行治疗)和观察组(在对照组基础上服用八珍散,并根据症候加减),每组均为44例。观察两组术中及术后情况,观察两组手术前后胃肠道症状分级量表(GSRS)评分、胃肠功能水平、细胞免疫功能、体液免疫功能,观察两组手术并发症发生情况。结果:两组的手术时间、术中出血量、术中尿量对比,差异无统计学意义(P>0.05),观察组的术后首次排气时间、排便时间、进食时间均比对照短(P<0.05)。手术前1 d,两组的GSRS评分、胃动素、胃泌素、胆囊收缩素水平、成熟T淋巴细胞(CD3+)、辅助性T淋巴细胞(CD4+)、杀伤性T淋巴细胞(CD8+)、免疫蛋白A(IgA)、免疫蛋白M(IgM)、免疫蛋白G(IgG)、补体3(C3)、补体4(C4)对比,差异无统计学意义(P>0.05)。手术后10 d,两组的GSRS评分、胃动素、胃泌素、胆囊收缩素水平、CD3+、CD4+、CD8+均比手术前1 d低(P<0.05),两组的IgA、IgM、IgG、C3、C4均比手术前1 d高(P<0.05),且观察组的GSRS评分比对照组低(P<0.05),观察组的胃动素、胃泌素、胆囊收缩素水平、CD3+、CD4+、CD8+水平、IgA、IgM、IgG、C3、C4水平均比对照组高(P<0.05)。观察组手术并发症发生率比对照组低(4.55%与18.18%,P<0.05)。结论:对行腹腔镜结直肠根治术后患者采用八珍散加减治疗,明显改善患者的胃肠道功能,可减轻手术对机体细胞、体液免疫功能以及胃肠功能影响,降低手术并发症的发生率。
Abstract:
Objective:To explore the influence of Bazhen powder on gastrointestinal function and immune function after radical resection of colorectal cancer.Methods:A total of 88 patients with colorectal cancer who were to be treated for surgical treatment were selected as the research objects.According to the principle of random drawing,they were divided into a control group(treatment with conventional surgical methods)and an observation group(Bazhen powder on the basis of the control group,and according to Symptom addition and subtraction),each group has 44 cases.Observe the intraoperative and postoperative conditions of the two groups,observed the Gastrointestinal symptom grading scale(GSRS)score,gastrointestinal function level,cellular immune function,and humoral immune function of the two groups before and after the operation,and observed the occurrence of surgical complications in the two groups.Results:There was no significant difference in the operation time,intraoperative blood loss,and intraoperative urine output between the two groups(P>0.05).The first postoperative exhaust time,defecation time,and eating time of the observation group were shorter than those of the control group(P<0.05).1 day before surgery,the GSRS scores,motilin,gastrin,cholecystokinin levels,mature T lymphocytes(CD3+),helper T lymphocytes(CD4+),killer T lymphocytes(CD8+),immunity compared with protein A(IgA),immune protein M(IgM),immune protein G(IgG),adequate complement 3(C3),adequate complement 4(C4),the difference was not statistically significant(P>0.05).Ten days after surgery,the GSRS scores,motilin,gastrin,cholecystokinin levels,CD3+,CD4+,and CD8+ of the two groups were lower than those of the first day before surgery(P<0.05).The IgA,IgM,IgG,and C3 levels of the two groups were,C4 were higher than 1 d before surgery(P<0.05),and the GSRS score of the observation group was lower than that of the control group(P<0.05).The levels of motilin,gastrin,cholecystokinin,CD3+,CD4+,CD8+levels,IgA,IgM,IgG,C3,C4 levels were higher than those of the control group(P<0.05).The incidence of surgical complications in the observation group was lower than that in the control group(4.55% vs 18.18%,P<0.05).Conclusion:The use of Bazhen powder for patients undergoing laparoscopic radical colorectal surgery can significantly improve the gastrointestinal function of the patient,reduce the impact of surgery on the body cells,humoral immune function and gastrointestinal function,and reduce surgical complications of disease.

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备注/Memo

备注/Memo:
基金项目:河南省科技厅科技攻关项目(162102310109)
更新日期/Last Update: 2021-05-10